US, CT and MR imaging characteristics of nephroblastomatosis

Rohrschneider, W; Weirich, A.; Rieden, K.; Darge, Kassa; Tröger, J.; Graf, Norbert

doi:10.1007/s002470050378

Cited by 118 publications

(36 citation statements)

References 19 publications

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“…However, the cross sectional imaging like CT scan and MRI have been shown to be superior to ultrasonography. [28] CT has been found to have accuracy of 82% and capable of an explicit report in 89% of all cases. [9]…”

Section: Introductionmentioning

confidence: 99%

Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Olukayode

Osuoji

Rachael

et al. 2014

Indian J Med Paediatr Oncol

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Context:Abnormal abdominal distension in a child is usually a source of great concern and apprehension in both the parents and the pediatric surgeon. Although Wilms’ tumor is the most common malignant abdominal childhood tumor, usually causing abdominal distension, many other less common causes can also result in abdominal distension. Therefore, early diagnosis of Wilms’ tumor and distinguishing it from all these other causes is essential.Aims:We intend to document the pattern of computed tomography (CT) scan findings in patients with Wilms’ tumor and the peculiarity of its radiological presentation in this environment, highlighting its accuracy and advantages over other imaging modalities.Settings and Design:This is a prospective descriptive study conducted between January, 2011 to January 2012, where all infants, 6-96 months of age, who were suspected to have Wilms’ tumor were made to undergo CT scan examination as part of their management work-up. It was carried out in a teaching hospital.Subjects and Methods:The study performed on 12 children age range of 6-96 months old underwent abdominal CT scans as part of their clinical work-up using a GE Hi-speed dual CT scanner®. Pre- and post-contrast images were acquired and assessed by the radiologists. They were operated and their radiological and histopathology results were correlated.Statistical Analysis:All data was entered into a Microsoft word excel spread sheet and analyzed by simple analysis. Percentages and proportions were determined for categorical variables.Results:Of the 12 patients seen, nearly 75% were males, with a male to female ratio of 3:1 and an average age of 37 months. The right sided tumors were slightly more than the left and nearly 25% were bilateral. Approximately 17% showed punctuate calcifications. Heterogeneous contrast enhancement was seen in all the cases, vascular encasement in three and lymphadenopathy in six cases. There was no bony involvement in any of them but 75% of the masses seen, crossed the midline. Histological confirmation of Wilms’ tumor was obtained in all cases.Conclusions:Majority of the tumors seen in this study crossed the midline and a few of them showed calcification. CT scan is relevant and accurate in investigating children with Wilms’ tumor as it reveals concomitant lesions with involvement of the abdominal vessels and lymph nodes.

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Section: Introductionmentioning

confidence: 99%

Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Olukayode

Osuoji

Rachael

et al. 2014

Indian J Med Paediatr Oncol

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“…Tumor rupture was considered to be present if there was ascites beyond the culde-sac, extra-capsular retroperitoneal fluid, or fat stranding around the kidney, with ascites being most predictive of rupture [5]. Contralateral synchronous lesions were defined as non-cystic lesions of any size in the contralateral kidney [6] (Fig. 3).…”

Section: Methodsmentioning

confidence: 99%

Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children’s Oncology Group

et al. 2014

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Background CT and MRI are both used for abdominal staging of pediatric renal tumors. The diagnostic performance of the two modalities for local and regional staging of renal tumors has not been systematically evaluated. Objective To compare the diagnostic performance of CT and MRI for local staging of pediatric renal tumors. Materials and methods The study population was derived from the AREN03B2 study of the Children's Oncology Group. Baseline abdominal imaging performed with both CT and MRI within 30 days of nephrectomy was available for retrospective review in 82 renal tumor cases. Each case was evaluated for capsular penetration, lymph node metastasis, tumor thrombus, preoperative tumor rupture, and synchronous contralateral lesions. The surgical and pathological findings at central review were the reference standard. Results The sensitivity of CT and MRI for detecting capsular penetration was 68.6% and 62.9%, respectively (P=0.73), while specificity was 86.5% and 83.8% (P=1.0). The sensitivity of CT and MRI for detecting lymph node metastasis was 76.5% and 52.9% (P=0.22), and specificity was 90.4% and 92.3% (P=1.0). Synchronous contralateral lesions were identified by CT in 4/9 cases and by MRI in 7/9 cases. Conclusion CT and MRI have similar diagnostic performance for detection of lymph node metastasis and capsular penetration. MR detected more contralateral synchronous lesions; however these were present in a very small number of cases. Either modality can be used for initial loco–regional staging of pediatric renal tumors.

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“…Alternatively, If nephroblastomatosis is discovered incidentally in a child there is a 1% subsequent chance of developing WT [33]. Serial imaging is recommended in children with WT with nephroblastomatosis, in a patient with known nephroblastomatosis and as a screen for children with syndromes associated with nephroblastomatosis (the same as those associated with WT) or WT [35]. The hallmark of neoplastic transformation of benign nephroblastomatosis to malignant appears to be renal enlargement.…”

Section: Histologymentioning

confidence: 96%

“…T1 weight magnetic resonance scanning is the best way to make the diagnosis but not cost-effective as a screening tool. Serial ultrasounds, once the diagnosis of nephroblastomatosis has been made appear to be the best way to follow children with this problem [35].…”

Section: Histologymentioning

confidence: 99%

Wilms tumor: progress to date and future considerations

Ehrlich

2001

Expert Review of Anticancer Therapy

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Wilms tumor is the most common tumor of renal origin found in children. In the last 50 years, remarkable progress has been made in the treatment and understanding of children with Wilms tumor. Through the development of multiagent chemotherapy and cooperative pediatric interdisciplinary groups conducting large randomized controlled clinical trials, survival has improved dramatically. In the next century it is expected that 80% of children with Wilms tumor will be long-term survivors. Therapy is progressing towards a risk-based management based not only on stage and histology but also incorporated genetic markers. This article reviews progress to date and possible future directions in the treatment of Wilms Tumor.

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US, CT and MR imaging characteristics of nephroblastomatosis

Cited by 118 publications

References 19 publications

Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Pattern of computed tomography scan findings in children with Wilms’ tumor in a tertiary hospital in Lagos, Nigeria

Comparison of diagnostic performance of CT and MRI for abdominal staging of pediatric renal tumors: a report from the Children’s Oncology Group

Wilms tumor: progress to date and future considerations

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