Usage of atomic force microscopy for detection of the damaging effect of CdCl2 on red blood cells membrane

Demchenkov, E. L.; Nagdalian, Аndrey Аshotovich; Budkevich, Roman O.; Oboturova, Natalya; Okolelova, A.I.

doi:10.1016/j.ecoenv.2020.111683

Cited by 44 publications

(23 citation statements)

References 45 publications

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“…At the same time, this process is generalized. The developed septic coagulopathy is accompanied by a rapid release of pro-inflammatory cytokines and activation of the blood clotting system, which leads to the development of disseminated intravascular coagulation (DIC) syndrome [29][30][31][32][33]. In the case of COVID-19 infection, as well as with other infections, DIC syndrome is mainly inflammatory and manifests itself in the form of a systemic inflammatory response syndrome.…”

Section: Introductionmentioning

confidence: 99%

Tissue Dental Status and Features of Periodontal Microcirculation in Patients with New COVID-19 Coronavirus Infection.

Remizova¹,

Dzgoeva²,

Tingaeva³

et al. 2021

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Severe hemostatic disorders against the background of COVID-19 have a significant effect on the state of dental status. The study aimed to improve the effectiveness of dental care for patients with COVID-19 disease. To study the dental status of patients with COVID-19 undergoing inpatient treatment, to compare the change in saliva pH with the results of SARS-CoV-2 detection in paired nasopharyngeal smears and saliva samples, to study the microcirculation and oxygenation level of periodontal tissues in patients with moderate and severe COVID-19 undergoing inpatient treatment. 194 people were examined, including 112 patients with the new COVID 19 coronavirus infection and 82 comparison group without concomitant pathology. All patients are divided into five age groups according to their recommendations. The complex of examination included assessment of dental status, determination of saliva pH, the study of microcirculation and oxygenation in the periodontium, and on the phalanx of the index finger of the right hand. Analysis of the results of the study shows that when assessing the dental status, the most characteristic complaints were dryness of the oral cavity, ageusia or hypogeusia, anosmia, or hyposmia. Gum bleeding was observed in two older age groups: in patients aged 45-54 years in 20% of cases, in 55-64 years -18.5% of cases. Less than a quarter of the patients complained of hypersensitivity of the teeth. The study of the saliva pH level revealed normal indicators of the acid-base balance of the oral cavity, which did not depend on the results of the PCR test for COVID-19.

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Section: Introductionmentioning

confidence: 99%

Tissue Dental Status and Features of Periodontal Microcirculation in Patients with New COVID-19 Coronavirus Infection.

Remizova¹,

Dzgoeva²,

Tingaeva³

et al. 2021

Pharmacophore

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“…The follow-up duration was 14 days. The animals were examined every day, considering the protocol of the experiment and the number of living and dead animals [20]. At the end of the follow-up period, a half-year dose (LD50) was calculated.…”

Section: Methodsmentioning

confidence: 99%

Assessment of the Biosafety of Microorganisms and their Joint Composition

Luneva¹,

Lysenko²,

Гнеуш³

et al. 2021

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This publication presents the results of studying the biosafety of microorganisms used for the development of a biological product-a litter destructor, both individually and in a joint composition. In the experiment, the culture of Stylonychia (Stylonychia mytilus) and laboratory animals (rabbits, mice, and rats) were used. Based on a series of preclinical studies, it was found that the studied microorganisms individually do not indicate any symptoms of virulence, toxigenicity, toxicity and do not give an affirmative counteraction to the formation of hemolysin. The results of the express method showed that the aqueous and acetone extracts obtained from the joint microbial composition did not have a detrimental effect on the culture of protozoa, the viability in all groups was 100.0%. The analysis of the dermonecrotic effect of the studied microbial preparation demonstrated that the studied extracts did not cause hemorrhage, hyperemia, peeling, edema, and other pathology indicating an inflammatory process on the skin of laboratory rabbits. Conducting an acute experiment confirmed the safety of the studied microbial consortium, since during the research the laboratory mice remained active, mobile, no signs of poisoning or other pathology were found, and the conducted pathoanatomical autopsy did not reveal lesions of the parenchymal organs of the laboratory test objects. In general, the results of the studies indicated that the investigated cultures of microorganisms and their joint composition in the composition of the biological product-destructor do not show a toxic impact on the body of lab test objects, which confirms their harmlessness.

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“…However, there are some disadvantages of using them, which include a limited range of pharmacological activity (unidirectional therapeutic effect) and irritating effect on treated skin [19][20][21]. To eliminate or minimize these shortcomings, it is significant to develop formulations of ointment compositions, optimize their composition, and study their properties.…”

Section: Introductionmentioning

confidence: 99%

Study of Wound-Healing Ointment Composition based on Highly Dispersed Zinc Oxide Modified with Nanoscale Silver

Blinova¹,

Blinov²,

Baklanova³

et al. 2021

Int j pharm phytopharm res

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A complex modern study of the ratio effect of components of an ointment composition based on highly dispersed Zinc oxide modified with nanoscale silver on its physical and chemical properties is performed. It was found that at a concentration of glycerol equal to C = 10%, and at a concentration of methylcellulose C = 3%, the value of the active acidity of the ointment composition is optimal (pH = 6.5-7). Studies of the structural and mechanical properties of the ointment composition have shown that the wound-healing ointment composition is elastic and has thixotropy, which makes it possible to use it in the treatment of wound surfaces with complex relief.

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Usage of atomic force microscopy for detection of the damaging effect of CdCl2 on red blood cells membrane

Cited by 44 publications

References 45 publications

Tissue Dental Status and Features of Periodontal Microcirculation in Patients with New COVID-19 Coronavirus Infection.

Tissue Dental Status and Features of Periodontal Microcirculation in Patients with New COVID-19 Coronavirus Infection.

Assessment of the Biosafety of Microorganisms and their Joint Composition

Study of Wound-Healing Ointment Composition based on Highly Dispersed Zinc Oxide Modified with Nanoscale Silver

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