Usages et bon usage des benzodiazépines anxiolytiques et hypnotiques

Soeiro, Thomas; Mégard, R.; Micallef, Joëlle; Rolland, Benjamin; Chappuy, Mathieu

doi:10.1016/j.amp.2021.08.009

Cited by 5 publications

(2 citation statements)

References 64 publications

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“…This outcome was further supported by results in the OFT performed in middle-aged mice, which, although showing a trend toward a dose-dependent decrease in the exploratory activity in the diazepam-treated animals, did not reveal any significant difference between groups. This anxiogenic-like effect may be related to a paradoxical effect of benzodiazepines as previously described for several positive GABA-A modulators, such as allopregnanolone, barbiturates, ethanol, and benzodiazepines [ 40 , 41 ] including diazepam [ 42 ].…”

Section: Discussionmentioning

confidence: 74%

Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach

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Niot

Kyheng³

et al. 2021

Transl Psychiatry

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Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at two different doses, has an irreversible effect on cognition, (ii) and whether there is an age-dependent effect. One hundred and five C57Bl/6 male mice were randomly assigned to the 15 mg/kg/day, the 30 mg/kg/day diazepam-supplemented pellets, or the control group. Each group comprised mice aged 6 or 12 months at the beginning of the experiments and treated for 16 weeks. Two sessions of behavioral assessment were conducted: after 8 weeks of treatment and after treatment completion following a 1-week wash-out period. The mid-treatment test battery included the elevated plus maze test, the Y maze spontaneous alternation test, and the open field test. The post-treatment battery was upgraded with three additional tests: the novel object recognition task, the Barnes maze test, and the touchscreen-based paired-associated learning task. At mid-treatment, working memory was impaired in the 15 mg/kg diazepam group compared to the control group (p = 0.005). No age effect was evidenced. The post-treatment assessment of cognitive functions (working memory, visual recognition memory, spatial reference learning and memory, and visuospatial memory) did not significantly differ between groups. Despite a cognitive impact during treatment, the lack of cognitive impairment after long-term treatment discontinuation suggests that benzodiazepines alone do not cause irreversible deleterious effects on cognitive functions and supports the interest of discontinuation in chronically treated patients.

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Section: Discussionmentioning

confidence: 74%

Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach

Carton

Niot

Kyheng³

et al. 2021

Transl Psychiatry

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“…Indeed, France is one of the largest consumers of benzodiazepines in the world, and their chronic use could lead to undesirable effects such as deleterious impact on learning outcomes in addition to substance use disorders, drowsiness, falls or hypotension (Bonnay et al. 2021 ). In our study, the reasons for use were mostly medical treatment (78.3%), other (17.0%), search for a recreational effect (10.3%) and help with concentration (6.7%).…”

Section: Discussionmentioning

confidence: 99%

An overview of the use of psychoactive substances among students at the University of Lille during the COVID-19 health crisis: Results of the PETRA study

Carton,

Bastien,

Chérot

et al. 2023

Dialogues in Clinical Neuroscience

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Objectives Students represent a population at risk for substance abuse. That risk may have been exacerbated by the COVID-19 pandemic. We aimed to describe substance abuse among students and to compare consumption according to the university field. Methods A self-administered questionnaire was sent by email to all students at the University of Lille, France, between March and July 2021. This anonymous questionnaire included questions about sociodemographic characteristics, university courses and the use of psychoactive substances (frequency, reasons, routes of administration) since the first university year. Results Among the 4431 students who responded (response rate 6.1%), eighty percent declared having used alcohol since the first university year, 34% cannabis, 15.4% benzodiazepines, 14.7% opioid drugs, 7.5% cocaine, 6.8% nitrous oxide and 6.5% MDMA. More than 20% of the users of cannabis, benzodiazepines, amphetamines and cocaine reported having already felt dependent. Recreational use was described by more than 10% of benzodiazepine or opioid drug users. Nitrous oxide use was significantly more frequent in the health and sport field ( p < 0.001). Tobacco, benzodiazepine, cannabis and MDMA uses were significantly more frequent in the humanities and social sciences/art, language and literature fields ( p < 0.001). Conclusion Prevention measures focusing on alcohol, cannabis, illicit psychostimulants, nitrous oxide and prescription drugs are required in the student population.

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