Use and Safety Perceptions Regarding Herbal Supplements: A Study of Older Persons in Southeast Idaho

Snyder, Frank; Dundas, Mary L.; Kirkpatrick, Carol F.; Neill, Karen

doi:10.1080/01639360802634043

Cited by 34 publications

(26 citation statements)

References 34 publications

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“…The rising popularity of herbal dietary supplements probably originates from an increased awareness of consumers toward well-being and health in general and then from the desire to prevent illness by an optimal nutritional status. A relevant reason for the favor these products enjoy with the public is the belief that they are not only effective but also safe because herbal remedies are of natural origin and used for long time (Snyder et al 2009;Chauhan et al 2013). This lack of criticism is surprising, particularly as there is no shortage of criticism for conventional medicine.…”

Section: Discussionmentioning

confidence: 93%

Hepatotoxicity of green tea: an update

2015

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Green tea (GT), obtained from the leaves of Camellia sinensis (L.) Kuntze (Fam. Theaceae), is largely used for its potential health benefits such as reduction in risk of cardiovascular diseases and weight loss. Nevertheless, it is suspected to induce liver damage. Present work reviews the hepatic adverse reactions associated with GT-based herbal supplements, published by the end of 2008 to March 2015. A systematic research was carried out on PubMed, MedlinePlus, Scopus and Google Scholar databases, without any language restriction. Moreover, some accessible databases on pharmacovigilance or phytovigilance were consulted. The causality assessment was performed using the CIOMS/RUCAM score. Nineteen cases of hepatotoxicity related to the consumption of herbal products containing GT were identified. The hepatic reactions involved mostly women (16/19); the kind of liver damage was generally classified as hepatocellular (16/19). The causality assessment between consumption of herbal preparation and hepatic reaction resulted as probable in eight cases and as possible in eleven cases. In seven cases, patients used preparations containing only GT, while twelve reactions involved patients who took multicomponent preparations (MC). The reactions induced by GT had a generally long latency (179.1 ± 58.95 days), and the outcome was always resolution, with recovery time of 64.6 ± 17.78 days. On the contrary, liver injury associated with MC had a shorter latency (44.7 ± 13.85 days) and was more serious in four cases that required liver transplantation and, when resolution occurred, the recovery time was longer (118.9 ± 38.79). MC preparations contained numerous other components, many of which are suspected to induce liver damage, so it is difficult to ascribe the toxicity to one specific component, e.g., GT. Present data confirm a certain safety concern with GT, even if the number of hepatic reactions reported is low considering the great extent of use of this supplement. The mechanism of GT hepatotoxicity remains unclear, but factors related to the patient are becoming predominant. A major safety concern exists when GT is associated with other ingredients that can interact between them and with GT, enhancing the risk of liver damage. Patients should be discouraged from using herbal or dietary supplements containing complex mixtures and should be encouraged to use herbal and dietary supplement possibly under supervision of healthcare professionals.

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Section: Discussionmentioning

confidence: 93%

Hepatotoxicity of green tea: an update

2015

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“…There is a tremendous potential for the excessive or inappropriate use of these products [22][23][24][25][26][27]. In addition, this may compromised the purchasing of medicines especially where there are high co-payments.…”

Section: Expert Commentarymentioning

confidence: 99%

Over-the-counter medicine and dietary supplement consumption among academic youth in Poland

Bochenek

Godman

Lipowska

et al. 2016

Expert Review of Pharmacoeconomics & Outcomes Research

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This version is available at https://strathprints.strath.ac.uk/55549/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the AbstractOver-the-counter (OTC) medicines and dietary supplements are increasingly popular in Poland, potentially improving overall health but also posing a threat to public health. The study goal is to characterize and assess behaviors related to use of OTC medicines and dietary supplements among Polish university students. A questionnaire-based survey was performed with students divided into groups (gender, subjects studied, period of studies). The majority of students declared using the products, significantly more females and younger students in their early years. Females tended to be more attentive to product information. Students with a background in biological or medical sciences were also more attentive and less influenced by advertising. We conclude that the differences between the defined groups of students should be utilized in tailored educational activities, aiming to rationalize high consumption of OTC medicines and dietary supplements. Targeting other, especially poor and less-educated groups, should follow.

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“…Although dietary supplements are perceived as safe, the current regulatory framework established by the Dietary Supplement Health and Education Act of 1994 requires less evidence of safety before marketing as assessed by the U.S. Food and Drug Administration (FDA) than is required for pharmaceuticals. The FDA and other regulatory bodies can take action against a manufacturer only if there is proven adulteration or injury from its supplement.…”

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confidence: 99%

Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network

et al. 2014

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Background The Drug-Induced Liver Injury Network (DILIN) studies hepatotoxicity due to conventional medications as well as herbals and dietary supplements (HDS). Rationale To characterize hepatotoxicity and its outcomes from HDS versus medications, patients with hepatotoxicity attributed to medications or HDS were enrolled prospectively between 2004 and 2013. The study took place among eight US referral centers that are part of the DILIN. Consecutive patients with liver injury referred to a DILIN center were eligible. The final sample comprised 130 (15.5%) of all subjects enrolled (839) who were judged to have experienced liver injury due to HDS. Hepatotoxicity due to HDS was evaluated by expert opinion. Demographic and clinical characteristics and outcome assessments including death and liver transplantation were ascertained. Cases were stratified and compared according to the type of agent implicated in liver injury; 45 had injury due to bodybuilding HDS, 85 due to non-bodybuilding HDS, and 709 due to medications. Main Results Liver injury due to HDS increased from 7% to 20% (p < 0.001) during the study period. Bodybuilding HDS caused prolonged jaundice (median 91 days) in young men but did not result in any fatalities or liver transplantation. The remaining HDS cases presented as hepatocellular injury, predominantly in middle-aged women and more frequently led to death or transplantation compared to injury from medications (13% vs. 3%, p < 0.05). Conclusions The proportion of liver injury cases attributed to HDS in DILIN has increased significantly. Liver injury from non-bodybuilding HDS is more severe than from bodybuilding HDS or medications, as evidenced by differences in unfavorable outcomes; death and transplantation.

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Use and Safety Perceptions Regarding Herbal Supplements: A Study of Older Persons in Southeast Idaho

Cited by 34 publications

References 34 publications

Hepatotoxicity of green tea: an update

Hepatotoxicity of green tea: an update

Over-the-counter medicine and dietary supplement consumption among academic youth in Poland

Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network

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