Use of a high b-value for diffusion weighted imaging of peritumoral regions to differentiate high-grade gliomas and solitary metastases

Han, Chao; Huang, Shumin; Guo, Jianfeng; Zhuang, Xiongjie; Han, Hao

doi:10.1002/jmri.24747

Cited by 30 publications

(46 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supporting this hypothesis, peritumoral ADC is lower in both anaplastic astrocytoma and glioblastoma compared to metastases (Pavlisa et al, 2009; Han et al, 2014). High b value diffusion imaging (3000 compared to the standard 1000) may slightly improve this approach, as one study found that using a minimum ADC value, the area under the curve (AUC) was 0.92 for b = 3000 compared to 0.89 for b = 1000 (Han et al, 2014). ADC in normal-appearing white matter, beyond the area of T2 signal abnormality, has also been analyzed.…”

Section: Differentiating Metastases From Similar-appearing Massesmentioning

confidence: 81%

Brain metastases: neuroimaging

Pope

2018

Handbook of Clinical Neurology

154

130

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is the cornerstone for evaluating patients with brain masses such as primary and metastatic tumors. Important challenges in effectively detecting and diagnosing brain metastases and in accurately characterizing their subsequent response to treatment remain. These difficulties include discriminating metastases from potential mimics such as primary brain tumors and infection, detecting small metastases, and differentiating treatment response from tumor recurrence and progression. Optimal patient management could be benefited by improved and well-validated prognostic and predictive imaging markers, as well as early response markers to identify successful treatment prior to changes in tumor size. To address these fundamental needs, newer MRI techniques including diffusion and perfusion imaging, MR spectroscopy, and positron emission tomography (PET) tracers beyond traditionally used 18-fluorodeoxyglucose are the subject of extensive ongoing investigations, with several promising avenues of added value already identified. These newer techniques provide a wealth of physiologic and metabolic information that may supplement standard MR evaluation, by providing the ability to monitor and characterize cellularity, angiogenesis, perfusion, pH, hypoxia, metabolite concentrations, and other critical features of malignancy. This chapter reviews standard and advanced imaging of brain metastases provided by computed tomography, MRI, and amino acid PET, focusing on potential biomarkers that can serve as problem-solving tools in the clinical management of patients with brain metastases.

show abstract

Section: Differentiating Metastases From Similar-appearing Massesmentioning

confidence: 81%

Brain metastases: neuroimaging

Pope

2018

Handbook of Clinical Neurology

154

130

View full text Add to dashboard Cite

show abstract

“…Whether the tumor core can be reliably discriminated between SBMs and GBMs with conventional MRI, even with several advanced MRI techniques such as DWI, PWI, MRS, DTI and ASL, is still have controversial [3; 8; 11; 35–37]. Previous studies have shown that APTw MRI can identify the tumor core mainly related to mobile amide proton content and cell density, which was not relevant to Gd enhancement [16; 18].…”

Section: Discussionmentioning

confidence: 99%

“…On conventional MRI, there is substantial overlap between the images of solitary brain metastases (SBMs) and glioblastomas (GBMs), as both manifest similar signal features and contrast enhancement patterns. Previously, investigators worldwide use DWI, PWI, MRS, and ASL perfusion imaging to differentiate between these tumors [8–11]. However, the distinction between these two types of tumors still has limited diagnostic specificity.…”

Section: Introductionmentioning

confidence: 99%

Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma

Lou

Zou

et al. 2017

Eur Radiol

View full text Add to dashboard Cite

Objectives To determine the utility of the amide proton transfer-weighted (APTw) MR imaging in distinguishing solitary brain metastases (SBMs) from glioblastomas (GBMs). Methods Forty-five patients with SBMs and forty-three patients with GBMs underwent conventional and APT-weighted sequences before clinical intervention. The APTw parameters and relative APTw (rAPTw) parameters in the tumor core and the peritumoral brain zone (PBZ) were obtained and compared between SBMs and GBMs. The receiver operating characteristic (ROC) curve was used to assess the best parameter for distinguishing between the two groups. Results The APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the tumor core were not significantly different between the SBM and GBM groups (P=0.141, 0.361, 0.221, 0.305, 0.578 and 0.448, respectively). However, the APTwmax, APTwmin, APTwmean, rAPTwmax, rAPTwmin or rAPTwmean values in the PBZ were significantly lower in the SBM group than in the GBM group (P<0.001). The APTwmin values had the highest area under the ROC curve 0.905 and accuracy 85.2% in discriminating between the two neoplasms. Conclusion As a noninvasive imaging method, APT-weighted MR imaging can be used to distinguish SBMs from GBMs.

show abstract

“…Conventionally, DWI is performed using endogenous water molecules. In clinical and preclinical settings, DWI has been used to measure molecular movement of water in order to study tissue microstructure …”

mentioning

confidence: 99%

“…In clinical and preclinical settings, DWI has been used to measure molecular movement of water in order to study tissue microstructure. [1][2][3][4][5][6][7][8] Recently, hyperpolarized (HP) 13 C-MRI has emerged as a tool for monitoring perfusion and metabolism in vivo.…”

mentioning

confidence: 99%

Diffusion‐weighted imaging of hyperpolarized [¹³C]urea in mouse liver

Marco‐Rius

Gordon

Mattis

et al. 2017

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To compare the apparent diffusion coefficient (ADC) of hyperpolarized (HP) [ 13 C, 15 N]urea to the ADC of endogenous water in healthy and fibrotic mouse liver. Materials and Methods: ADC measurements for water and [ 13 C]urea were made in agarose phantoms at 14.1T. Next, the ADC of water and injected HP [ 13 C,15 N]urea were measured in eight CD1 mouse livers before and after induction of liver fibrosis using CCl 4 . Liver fibrosis was quantified pathologically using the modified Brunt fibrosis score and compared to the measured ADC of water and urea. Results: In cell-free phantoms with 12.5% agarose, water ADC was nearly twice the ADC of urea (1. D iffusion-weighted magnetic resonance imaging (DWI-MRI) techniques produce image intensities related to the Brownian motion of molecules. In the presence of strong magnetic field gradients, molecules that move freely lose signal more rapidly than molecules whose motions are restricted. Therefore, DWI contains information about the local environments of the molecules being imaged. Conventionally, DWI is performed using endogenous water molecules. In clinical and preclinical settings, DWI has been used to measure molecular movement of water in order to study tissue microstructure. [1][2][3][4][5][6][7][8] Recently, hyperpolarized (HP) 13 C-MRI has emerged as a tool for monitoring perfusion and metabolism in vivo.Using dynamic nuclear polarization (DNP), carbon-containing compounds are prepared outside of the MRI scanner to achieve an MR signal enhancement greater than 50,000-fold compared to standard conditions. 9 HP 13 C substrates have been previously used to image perfusion 10,11 and metabolism. 12,13 Recently, there has been considerable interest in measuring the diffusion properties of exogenously administered HP compounds. 14-17Because HP compounds have different chemical interactions with tissue and different compartmentalization than water, diffusion measurements using these compounds provide potentially novel biophysical information about tissues. The goal of this study was to compare the apparent diffusion coefficient (ADC) of an injected HP probe, View this article online at wileyonlinelibrary.com.

show abstract

Use of a high b-value for diffusion weighted imaging of peritumoral regions to differentiate high-grade gliomas and solitary metastases

Abstract: ADC values from DWI using a high b-value were found to distinguish HGG and SM. The lowest degree of overlap was obtained when an ADCMIN value was obtained at a b-value of 3000 s/mm(2) .

Cited by 30 publications

References 28 publications

Brain metastases: neuroimaging

Brain metastases: neuroimaging

Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma

Diffusion‐weighted imaging of hyperpolarized [¹³C]urea in mouse liver

Contact Info

Product

Resources

About

Use of a high b-value for diffusion weighted imaging of peritumoral regions to differentiate high-grade gliomas and solitary metastases

Abstract: ADC values from DWI using a high b-value were found to distinguish HGG and SM. The lowest degree of overlap was obtained when an ADCMIN value was obtained at a b-value of 3000 s/mm(2) .

Cited by 30 publications

References 28 publications

Brain metastases: neuroimaging

Brain metastases: neuroimaging

Applying protein-based amide proton transfer MR imaging to distinguish solitary brain metastases from glioblastoma

Diffusion‐weighted imaging of hyperpolarized [13C]urea in mouse liver

Contact Info

Product

Resources

About

Diffusion‐weighted imaging of hyperpolarized [¹³C]urea in mouse liver