Use of a Weight of Evidence Approach to Determine the Likelihood of Adverse Effects on Human Health from the Presence of Uranium Facilities in Port Hope, Ontario

Burtt, Julie; Ilin, Michael; Lane, Rachel; Thompson, Patsy; Phaneuf, M.; Reinhardt, P.

doi:10.4236/jep.2011.29134

JEP

2011

DOI: 10.4236/jep.2011.29134

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Use of a Weight of Evidence Approach to Determine the Likelihood of Adverse Effects on Human Health from the Presence of Uranium Facilities in Port Hope, Ontario

Julie Burtt¹,

Michael Ilin²,

Rachel Lane³

et al.

Abstract: The radium and uranium processing industry exists in Port Hope, Ontario, since 1932. Between 1932 and 1966

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Cited by 3 publications

References 24 publications

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Bioaccessibility of Uranium in Soil Samples from Port Hope, Ontario, Canada

Jovanović

Pan

Wong

2012

Environ. Sci. Technol.

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Adequate assessment of human health risk of uranium contamination at hazardous waste sites, which is an important step in determining the cleanup strategy, is based on bioavailability data. Bioavailability of uranium from contaminated soil has not been properly determined yet. Bioaccessibility is an in vitro conservative estimate of bioavailability and is thus frequently used for site-specific risk assessment. Bioaccessibility of uranium was measured in 33 soil samples from the Port Hope area in Ontario, Canada, by the physiologically based extraction test (PBET). Higher bioaccessibility values in the gastric plus intestinal phase, 48.4% ± 16.8%, than in the gastric phase, 20.8% ± 11.7%, are very probably the result of more efficient extraction of uranium from soil by intestinal fluid rich in carbonate ions. The observed variability of measured bioaccessibility values is discussed in light of the results of scanning electron microscope examination of the soil samples. Uranium bioaccessibility values in both gastric (acidic) and gastric plus intestinal (neutral) phases are higher in soil samples with smaller uranium-bearing particles and lower in samples where the uranium-bearing particles are larger. We postulate that the most important reason for variability of measured bioaccessibility values in Port Hope soil samples may be the difference in particle size of uranium-bearing particles.

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Bioaccessibility of Uranium in Soil Samples from Port Hope, Ontario, Canada

Jovanović

Pan

Wong

2012

Environ. Sci. Technol.

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COHERE – strengthening cooperation within the Canadian government on radiation research

Chauhan

Leblanc

Sadi

et al. 2021

International Journal of Radiation Biology

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An ecological study of cancer incidence in Port Hope, Ontario from 1992 to 2007

et al. 2013

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A plant processing radium and uranium ores has been operating in the town of Port Hope since 1932. Given the nuclear industry located in the community and ongoing public health concerns, cancer incidence rates in Port Hope were studied for a recent 16 year period (1992-2007) for continued periodic cancer incidence surveillance of the community. The cancer incidence in the local community for all cancers combined was similar to the Ontario population, health regions with similar socio-economic characteristics in Ontario and in Canada, and the Canadian population. No statistically significant differences in childhood cancer, leukaemia or other radiosensitive cancer incidence were observed, with the exception of statistically significant elevated lung cancer incidence among women. However, the statistical significance was reduced or disappeared when the comparison was made to populations with similar socio-economic characteristics. These findings are consistent with previous ecological, case-control and cohort studies conducted in Port Hope, environmental assessments, and epidemiological studies conducted elsewhere on populations living around similar facilities or exposed to similar environmental contaminants. Although the current study covered an extended period of time, the power to detect risk at the sub-regional level of analysis was limited since the Port Hope population is small (16,500). The study nevertheless indicated that large differences in cancer incidence are not occurring in Port Hope compared to other similar communities and the general population.

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Use of a Weight of Evidence Approach to Determine the Likelihood of Adverse Effects on Human Health from the Presence of Uranium Facilities in Port Hope, Ontario

Abstract: The radium and uranium processing industry exists in Port Hope, Ontario, since 1932. Between 1932 and 1966

Cited by 3 publications

References 24 publications

Bioaccessibility of Uranium in Soil Samples from Port Hope, Ontario, Canada

Bioaccessibility of Uranium in Soil Samples from Port Hope, Ontario, Canada

COHERE – strengthening cooperation within the Canadian government on radiation research

An ecological study of cancer incidence in Port Hope, Ontario from 1992 to 2007

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