Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population

Fusobacterium nucleatum: a commensal-turned pathogen

“…A few studies conducted in South America, Europe, and U.S. improve birth outcome following repeated periodontal treatment or daily use of antibacterial mouth rinse [56–58]. Unfortunately, several large-scale multi-center intervention studies employing a single-treatment therapy during the second trimester fail to demonstrate efficacy [59–61].…”

Scaling and Root Planing Performed on Pregnant Women With Mild to Moderate Periodontal Disease is Not Efficacious in Reducing Preterm Birth, Low Birth Weight, or Other Poor Pregnancy Outcomes

“…A more recent pseudorandom, single-blind, small controlled trial showed that there was a 75% statistically significant reduction in very preterm births among women who used an alcohol-free antimicrobial mouth rinse. 7 Although this mouth rinse study has considerable limitations, it addresses the possibility of other periodontal interventions that might reduce adverse pregnancy outcomes. Fourth, as shown with the contour-enhanced funnel plot in the meta-analysis study, there is a potential publication bias as well.…”

The effects of periodontal treatment on pregnancy outcomes

“…), two of which were excluded (Jeffcoat et al. , Sant'Ana et al. ) because the intervention was not randomly allocated.…”

“…), such regimes have not been used in RCTs to date. Results from a non‐randomized trial provide some evidence that interventions not likely to induce bacteremiae may improve pregnancy outcomes (Jeffcoat et al., ). In this trial, pregnant women who received an antimicrobial mouth rinse experienced fewer preterm births than water rinse controls.…”