2018
DOI: 10.1371/journal.pntd.0006909
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Use of anthropophilic culicid-based xenosurveillance as a proxy for Plasmodium vivax malaria burden and transmission hotspots identification

Abstract: Vector-borne diseases account for more than 17% of all infectious diseases, causing more than one million deaths annually. Malaria remains one of the most important public health problems worldwide. These vectors are bloodsucking insects, which can transmit disease-producing microorganisms during a blood meal. The contact of culicids with human populations living in malaria-endemic areas suggests that the identification of Plasmodium genetic material in the blood present in the gut of these mosquitoes may be p… Show more

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Cited by 11 publications
(12 citation statements)
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“…Because this filarial worm is not transmitted by mosquitoes, this finding is particularly important because it proves the feasibility of our approach to detect pathogens which are present in human blood and that are taken up with the bloodmeal by insect vectors. Our results corroborate previous findings where mosquitoes have been used to "sample" a variety of pathogens [6,8], including using the abdomens of blood-fed culicine mosquitoes to detect human malaria parasites [7]. There is scope to expand the array of pathogens circulating in the blood (including bacteria and fungi) to be tested for persistence and detection sensitivity using mosquito E/F.…”
Section: Discussionsupporting
confidence: 87%
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“…Because this filarial worm is not transmitted by mosquitoes, this finding is particularly important because it proves the feasibility of our approach to detect pathogens which are present in human blood and that are taken up with the bloodmeal by insect vectors. Our results corroborate previous findings where mosquitoes have been used to "sample" a variety of pathogens [6,8], including using the abdomens of blood-fed culicine mosquitoes to detect human malaria parasites [7]. There is scope to expand the array of pathogens circulating in the blood (including bacteria and fungi) to be tested for persistence and detection sensitivity using mosquito E/F.…”
Section: Discussionsupporting
confidence: 87%
“…Positivity detected in the mosquito E/F or carcasses was not predictive for the presence of infected people in the same household. In a recent study, Plasmodium infection incidence at the household level and the number of people infected were both correlated to the presence of Plasmodium-positive Culex quinquefasciatus collected from the same households [7]. Given the presence of Plasmodium-positive people in every household in our study, the predictive power of mosquito samples for malaria could not be tested.…”
Section: Plos Neglected Tropical Diseasesmentioning
confidence: 70%
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“…This heterogeneous distribution is reflected in local characteristics of vector biology, thus malaria epidemiology, following human dynamics that drive Amazonian occupation [ 37 ]. Interdisciplinary methods for disease intervention are common but rarely tailored to specific local conditions [ 38 , 39 ]. For effective eradication at a global scale, many aspects of public health need to be included, such epidemiological and syndromic surveillance, early diagnosis, clinical treatment, environmental sanitation, and improved methods for economical land use to reduce inequity and poverty [ 40 ].…”
Section: Discussionmentioning
confidence: 99%
“…There was no significant difference between Plasmodium DNA positivity rates from BGS traps and aspirators (2.7% versus 3.2%, respectively). Given the spatial correlation between Plasmodium DNA positivity rates in culicine mosquitoes and Plasmodium infection rates in humans, XS was recommended as a complementary strategy for estimating malaria prevalence [49].…”
Section: (B) Passive Surveillance Mosquito Non-vectors and Non-mosqumentioning
confidence: 99%