Use of cell-free collagen type I matrix implants for the treatment of small cartilage defects in the knee: clinical and magnetic resonance imaging evaluation

Schüttler, Karl F.; Schenker, Hanno; Theisen, Christina; Schofer, Markus D.; Getgood, Alan; Roessler, Philip P.; Struewer, Johannes; Rominger, Marga B.; Efe, Turgay

doi:10.1007/s00167-013-2747-x

Cited by 35 publications

(25 citation statements)

References 31 publications

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“…Step (Arthro-Kinetics Biotechnology, Krems/Danube, Austria) is a similar single-step cellfree procedure for treating smaller defects that uses the same membrane as Cartilage Regeneration System and its use has shown a 30-point increase in patient IKDC scores and a 2.5-point decrease in VAS pain scores at 4-year followup [36].…”

Section: Studies On Matrices For Matrix-assisted Cartilage Repairmentioning

confidence: 99%

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Wylie

Hartley

Kapron

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Articular cartilage has minimal endogenous ability to undergo repair. Multiple chondral restoration strategies have been attempted with varied results. Questions/purposes The purpose of our review was to determine: (1) Does articular chondrocyte transplantation or matrix-assisted articular chondrocyte transplantation provide better patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue compared with microfracture in prospective comparative studies of articular cartilage repair; and (2) which available matrices for matrix-assisted articular chondrocyte transplantation show the best patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue? Methods We conducted a systematic review of PubMed, CINAHL, and MEDLINE from March 2004 to February 2014 using keywords determined to be important for articular cartilage repair, including ''cartilage'', ''chondral'', ''cell source'', ''chondrocyte'', ''matrix'', ''augment'', ''articular'', ''joint'', ''repair'', ''treatment'', ''regeneration'', and ''restoration'' to find articles related to cell-based articular cartilage repair of the knee. The articles were reviewed by two authors (JDW, MKH), our study exclusion criteria were applied, and articles were determined to be relevant (or not) to the research questions. The Methodological Index for Nonrandomized Studies (MIN-ORS) scale was used to judge the quality of nonrandomized manuscripts used in this review and the Jadad score was used to judge the quality of randomized trials. Seventeen articles were reviewed for the first research question and 83 articles were reviewed in the second research question from 301 articles identified in the original systematic search. The average MINORS score was 9.9 (62%) for noncomparative studies and 16

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Section: Studies On Matrices For Matrix-assisted Cartilage Repairmentioning

confidence: 99%

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Wylie

Hartley

Kapron

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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“…Bone tracer uptake in areas with cartilage lesions was higher with an additional bone marrow edema pattern than in areas without. This finding is in addressed by means of chondral repair procedures, such as cell-free collagen implant transplantation or autologous chondrocyte transplantation (19,20). In osteochondral lesions, the osseous lesion also needs to be targeted.…”

Section: Discussionmentioning

confidence: 99%

Do Chondral Lesions of the Knee Correlate with Bone Tracer Uptake by Using SPECT/CT?

Đorđević¹,

Hirschmann²,

Rechsteiner³

et al. 2016

Radiology

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“…While the previous study only measured short-term outcomes, Schüttler et al [34] followed up on the same group of patients after four years to investigate the mid-term effects using the same variables. Both clinical and radiological outcomes continued to improve over time for every patient.…”

Section: Hydrogel Scaffoldsmentioning

confidence: 99%

Cell-Free Scaffolds as a Monotherapy for Focal Chondral Knee Defects

2020

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Chondral knee defects have a limited ability to be repaired. Current surgical interventions have been unable to regenerate articular cartilage with the mechanical properties of native hyaline cartilage. The use of a scaffold-based approach is a potential solution. Scaffolds are often implanted with cells to stimulate cartilage regeneration, but cell-based therapies are associated with additional regulatory restrictions, an additional surgical procedure for cell harvest, time for cell expansion, and the associated costs. To overcome these disadvantages, cell-free scaffolds can be used in isolation allowing native cells to attach over time. This review discusses the optimal properties of scaffolds used for chondral defects, and the evidence for the use of hydrogel scaffolds and hydrogel–synthetic polymer hybrid scaffolds. Preclinical and clinical studies have shown that cell-free scaffolds can support articular cartilage regeneration and have the potential to treat chondral defects. However, there are very few studies in this area and, despite the many biomaterials tested in cell-based scaffolds, most cell-free studies focused on a specific type I collagen scaffold. Future studies on cell-free scaffolds should adopt the modifications made to cell-based scaffolds and replicate them in the clinical setting. More studies are also needed to understand the underlying mechanism of cell-free scaffolds.

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Use of cell-free collagen type I matrix implants for the treatment of small cartilage defects in the knee: clinical and magnetic resonance imaging evaluation

Abstract: IV.

Cited by 35 publications

References 31 publications

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Do Chondral Lesions of the Knee Correlate with Bone Tracer Uptake by Using SPECT/CT?

Cell-Free Scaffolds as a Monotherapy for Focal Chondral Knee Defects

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