Use of confocal microscopy for nanoparticle drug delivery through skin

Zhang, Leshuai W.; Monteiro‐Riviere, Nancy A.

doi:10.1117/1.jbo.18.6.061214

Cited by 50 publications

(40 citation statements)

References 27 publications

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“…Inflammatory mediator production and function is an essential part of the host's response to infection and injury (Soeters and Grimble, 2009;Zhang and An, 2007). The current study explored whether TiO 2 NPs could interfere with the bioavailability and function of the inflammatory mediators CXCL8, IFN-γ, IL-1β, TNFα and IL-6, which are released by the PMNLs and, therefore, are found at inflammatory sites where they could be exposed to the TiO 2 NPs.…”

Section: Discussionmentioning

confidence: 98%

“…The extracellular tissue compartment contains a wide variety of inflammatory mediators, which vary in composition and quantity in both health and disease (Dinarello, 2000;Zhang and An, 2007). Inflammatory mediator production and function is an essential part of the host's response to infection and injury (Soeters and Grimble, 2009;Zhang and An, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, considerable attention is given to both the potential hazards of NP exposures (Chan et al, 2011;Jin et al, 2011;Shukla et al, 2011;Yazdi et al, 2010) and also, contrastingly, to their therapeutic use (Holpuch et al, 2010;Zhang and Monteiro-Riviere, 2013). Many studies concerning the toxicology of NPs and their interactions with a wide range of tissues and cells continue to be reported.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies concerning the toxicology of NPs and their interactions with a wide range of tissues and cells continue to be reported. However, the modelling of NP exposures to tissues is complex, given the propensity for NP aggregation (Zhang, 2014) and for the NPs to strongly adsorb biomolecules to their surfaces (Xia et al, 2011). Consequently, at the cellular level, interactions are often with the NP surface biomolecule corona and not the particle itself (Tenzer et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis

Batt¹,

Milward²,

Chapple³

et al. 2018

eCM

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The interaction between TiO 2 nanoparticles (NPs) and inflammatory cytokines, including CXCL8, a clinically relevant pro-inflammatory chemokine, was investigated. TiO 2 is present in tissues adjacent to failing implanted Ti (titanium) devices. TiO 2 NPs were shown to bind to CXCL8 in vitro, causing perturbation of quantification of CXCL8 by ELISA, in both simple and complex protein panels, in a dose-dependent manner. Binding between TiO 2 NPs and CXCL8 was demonstrated by protein gel electrophoresis. TiO 2 NPs were also shown to inactivate the chemoattractant property of CXCL8 in a dose-dependent manner, suggesting that the binding between TiO 2 NPs and CXCL8 is likely to be clinically relevant. The results of this study disputed the applicability of detection of CXCL8 by ELISA in systems where TiO 2 NPs were present. Clinically, the disruption of neutrophil chemotaxis due to CXCL8 binding to TiO 2 NPs might result in a hampered inflammatory response.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis

Batt¹,

Milward²,

Chapple³

et al. 2018

eCM

View full text Add to dashboard Cite

show abstract

“…A thorough discussion of the application of this technique on evaluating nanoparticle skin permeation has been previously discussed. 39 The FITClabeled nanoparticles exhibited excitation and emission wavelengths of 492 nm and 510 nm, respectively, as determined by fluorescent spectroscopy.…”

Section: In Vivo Skin Permeation Assessmentmentioning

confidence: 99%

Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate

Hsiao

Peng

Tang

et al. 2016

IJN

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In this study, we investigated the effect of (ethylene glycol) (PEG) and PEG–oleylamine (OAm) functionalization on the skin permeation property of gold nanoparticles (GNS) in vivo. Chemisorption of polymers onto GNS was verified by a red shift in the ultraviolet–visible spectrum as well as by a change in the nanoparticle surface charge. The physicochemical properties of pristine and functionalized nanoparticles were analyzed by ultraviolet–visible spectroscopy, zeta potential analyzer, and transmission electron microscopy. Transmission electron microscopy revealed that the interparticle distance between nanoparticles increased after GNS functionalization. Comparing the skin permeation profile of pristine and functionalized GNS, the follicular deposition of GNS increased twofold after PEG–OAm functionalization. Moreover, PEG- and PEG–OAm-functionalized nanoparticles were able to overcome the skin barrier and deposit in the deeper subcutaneous adipose tissue. These findings demonstrate the potential of PEG- and PEG–OAm-functionalized GNS in serving a multitude of applications in transdermal pharmaceuticals.

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Interfacial wettability and mass transfer characterizations for gas–liquid–solid triple‐phase catalysis

et al. 2022

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Heterogeneous catalysis is inseparable from interfacial mass transfer and chemical reaction processes determined by the structure and microenvironment. Different from hightemperature thermochemical processes, photo-and electrocatalysis operated at mild conditions often involve both gas and liquid phases, making it important but challenging to characterize the reaction process typically occurring at the gas-liquid-solid interface. Herein, we review the scope, feasibility, and limitation of ten types of currently available technologies used to characterize interfacial wettability and mass transfer properties of various triple-phase catalytic reactions. The review summarizes techniques from macroscopic contact angle measurement to microscopic environment electron microscopy for investigating the wettability-controlled structure of triple-phase interfaces. Experimental and computational methods in revealing the interfacial mass transfer process have also been systematically discussed, followed by a perspective on the opportunities and challenges of advanced characterization methods to help understand the fundamental reaction mechanism of triple-phase catalysis.

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Use of confocal microscopy for nanoparticle drug delivery through skin

Cited by 50 publications

References 27 publications

TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis

TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis

Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate

Interfacial wettability and mass transfer characterizations for gas–liquid–solid triple‐phase catalysis

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