Use of corticosteroids is not associated with repeated vertebroplasty or kyphoplasty within one year after the surgery in patient older than 50 years

Abstract

ObjectiveThe aim of this study was to investigate whether corticosteroid use increases the incidence of repeated PVP or kyphoplasty patients older than 50 years.MethodsThis study enrolled the data of 2,753 eligible patients from the Taiwan National Health Insurance Research Database who were exposed to systemic corticosteroids for at least 3 months during the first year preceding the first PVP or kyphoplasty. These steroid users were matched 1:1 in age, sex, and the index date of surgery with non-user controls during the enrollment period.All patients were followed for 1 year after the first PVP or kyphoplasty. The incidence of repeated PVP or kyphoplasty was compared between the steroid users and controls. A Cox proportional hazards model was developed to account for multiple confounding factors.ResultsThe number of patients receiving repeated PVP or kyphoplasty was 233 (8.46%) and 205 (7.45%) in the corticosteroid and control groups, respectively. The Cox proportional hazards model revealed no association between corticosteroid use and repeated PVP or kyphoplasty.ConclusionsSystemic corticosteroid use for longer than 3 months is not associated with repeated PVP or kyphoplasty within one year of surgery in patient older than 50 years old.Level of evidenceLevel III, Therapeutic study.

The role of vertebroplasty in steroid-induced vertebral osteoporotic fractures

“…40 Intradiscal cement leakage should be avoided because there is an association between adjacent level compression and intradiscal cement leak. 12,29 New Vertebral fracture The occurrence of new OVFs in patients of steroidinduced vertebral fractures was discussed widely; some clinical studies 11,24,36 reported an increased incidence of new OVFs following vertebroplasty and others 15,23 stated that the rate is the same without a difference. Koch et al 23 and others 9,15 reported that patients with G-OVFs experience levels of pain relief and development of new fractures after PV similar to those with primary osteoporotic vertebral fractures.…”

“…12,29 New Vertebral fracture The occurrence of new OVFs in patients of steroidinduced vertebral fractures was discussed widely; some clinical studies 11,24,36 reported an increased incidence of new OVFs following vertebroplasty and others 15,23 stated that the rate is the same without a difference. Koch et al 23 and others 9,15 reported that patients with G-OVFs experience levels of pain relief and development of new fractures after PV similar to those with primary osteoporotic vertebral fractures. There was another study 28 stating that adverse effects on bone are mainly due to underlying autoimmune or inflammatory disorders.…”