Use of Curcumin in Multiple Myeloma patients intolerant of steroid therapy

Ramakrishna, Raj; Diamond, Terrence; Alexander, William; Manoharan, A.; Golombick, Terry

doi:10.1002/ccr3.2735

Cited by 16 publications

(14 citation statements)

References 24 publications

(62 reference statements)

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“…CUR (3-4 g, daily) in 15 multiple myeloma patients (age > 55 years), when used in a combination regimen, showed progression-free survival without the adverse effects of steroid-based combination therapies indicating that CUR may be an alternative treatment to corticosteroids in combination with an immunomodulatory drug in multiple myeloma patients. 234 Treatment with oral CUR (2 g/day) in 21 lymphocytosis patients for 2 months decreased absolute lymphocyte but increased CD4, CD8, and NK cells. 235 CUR (50 mg/kg, twice a day for 6 days post-infection) therapy of cerebral malaria (CM) patients showed moderate antimalarial activity with the capacity to down-regulate excess production of pro-inflammatory cytokines and expression of adhesion molecules and reversing of cyto-adherence, improving survival and preventing neurological sequelae.…”

Section: Immunomodulatory Effects Of Curcumin Clinical Studiesmentioning

confidence: 96%

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

et al. 2021

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Curcuma longa (C. longa) or turmeric is a plant with a long history of use in traditional medicine, especially for treating inflammatory conditions C. longa and its main constituent, curcumin (CUR), showed various pharmacological effects such as antioxidant and anti-microbial properties. The updated knowledge of anti-inflammatory, antioxidant, and immunomodulatory effects of C. longa and CUR is provided in this review article. Pharmacological effects of C. longa, and CUR, including anti-inflammatory, antioxidant, and immunomodulatory properties, were searched using various databases and appropriate keywords until September 2020. Various studies showed anti-inflammatory effects of C. longa and CUR, including decreased white blood cell, neutrophil, and eosinophil numbers, and its protective effects on serum levels of inflammatory mediators such as phospholipase A2 and total protein in different inflammatory disorders. The antioxidant effects of C. longa and CUR were also reported in several studies. The plant extracts and CUR decreased

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Section: Immunomodulatory Effects Of Curcumin Clinical Studiesmentioning

confidence: 96%

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

et al. 2021

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“…In a recent clinical trial, patients with MM who received adjuvant curcumin treatment (at a dose of 3-4 g daily), as a replacement of dexamethasone due to intolerance to dexamethasone, showed decreased paraprotein load and plasmacytosis by 38 and 59%, respectively, when administered in combination with other anti-myeloma therapies. These findings indicated that curcumin may slow disease progression without inducing the adverse effects associated with steroid use (Ramakrishna et al, 2020). Besides, curcumin was shown to inhibit STAT3 phosphorylation in U266 MM cells in a dose-and time-dependent manner.…”

Section: Active Components Derived From Tcmms For Multiple Myeloma Curcuminmentioning

confidence: 81%

Active Components of Traditional Chinese Medicinal Material for Multiple Myeloma: Current Evidence and Future Directions

Cheng

et al. 2022

Front. Pharmacol.

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Multiple myeloma (MM) is a hematological malignancy characterized by clonal expansion of plasma cells in bone marrow, leading to the overproduction of monoclonal immunoglobulins. The clinical manifestations resulting from monoclonal proteins and malignant cells include signs of end-organ damage, such as hypercalcemia, renal failure, anemia, and bone lesions. Despite improvement in the survival of MM patients with use of myeloma-targeted and immunomodulatory therapies, MM remains an incurable disease. Moreover, patients with relapsed or refractory MM show poor survival outcomes. In recent years, there has been a growing interest in the use of traditional Chinese medicinal materials (TCMMs) for management of a wide spectrum of diseases. The bioactive ingredients derived from TCMMs hold great potential for the development of anticancer drugs. Here we summarize the evidence of the pharmacological effects of the active components in TCMMs on MM, including curcumin, resveratrol, baicalein, berberine, bufalin, cinobufagin, gambogic acid, ginsenoside, icariin, daidzin, formononetin, polysaccharides extracts from Hedyotis difus, and scutellarein. Available evidence indicates that the anti-MM effects of these bioactive ingredients are mediated via regulation of proliferation, apoptosis, autophagy, cell cycle, osteogenic differentiation, and drug resistance. In the future, the underlying mechanisms of the anti-MM effects of these components should be further investigated. Large-scale and well-designed clinical trials are also required to validate the efficacy of these bioactive constituents for MM.

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“…For this reason, it is desirable to use safe compounds that also present a good bioavailability. CCM is a hydrophobic polyphenol [ 21 ], with numerous pharmacological properties ( Figure 2 ), such as antiproliferative, anticancer [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], antidiabetic, antioxidant [ 34 ], and anti-inflammatory activities [ 35 , 36 , 37 ] and antimicrobial properties [ 38 ]. In general, the well-documented antiviral [ 38 , 39 , 40 ], anti-inflammatory, and immunomodulatory effects [ 41 ] of CCM, along with the evidence on anti-fibrotic [ 42 ] and lung protective properties [ 43 ] of this phytochemical in lung tissue, make it a likely molecule for the prevention and treatment of the infection with the SARS-CoV19 virus [ 44 ].…”

Section: Biological Actions Of Curcuminmentioning

confidence: 99%

“… The therapeutical effects of CCM are reflected by a large spectrum of action, as reported by the literature. The antitumor action of CCM was extensively explored in clinical and experimental conditions [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] as well as the antioxidant [ 34 ], anti-inflammatory [ 35 , 36 , 37 ], antibacterial [ 38 , 39 , 40 ] and immunomodulatory effects [ 41 ]. …”

Section: Figurementioning

confidence: 99%

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

et al. 2022

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Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein–curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.

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Use of Curcumin in Multiple Myeloma patients intolerant of steroid therapy

Cited by 16 publications

References 24 publications

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

Active Components of Traditional Chinese Medicinal Material for Multiple Myeloma: Current Evidence and Future Directions

Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin

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