Use of harmonic imaging without echocardiographic contrast to improve two-dimensional image quality

Spencer, KirkT; Bednarz, J.; Rafter, PatrickG; Korcarz, Claudia E.; Lang, RobertoM

doi:10.1016/s0002-9149(98)00457-3

Cited by 158 publications

(71 citation statements)

References 18 publications

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“…24,25) Currently, sophisticated UCG techniques are used to improve the visualization of cardiac microstructure. [26][27][28] Ultrasonic tissue characterization such as integrated backscatter and tissue harmonic imaging may have enabled us to distinguish myocardial edema from hypertrophy in more detail.…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction Induced by Cyclophosphamide in Blood Stem Cell Transplantation.

Mori

Yanagi

Maruyama³

et al. 2002

Jpn Heart J

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SUMMARYCardiac complications are major limiting factors regarding the success of high-dose chemotherapy supported by blood stem cell transplantation (BSCT). The cardiotoxicity of cyclophosphamide remains obscure relative to that of anthracyclines. The aim of this study was to estimate noninvasively the cardiotoxicity of cyclophosphamide administered during the pretransplant conditioning of BSCT for patients with various hematological diseases. A total of 27 consecutive patients were divided into two groups depending on the conditioning regimen, ie, group A (n=15) which received cyclophosphamide (median dose of 120 mg/kg; range 100 to 200 mg/kg) and group B (n=12) which did not. Ultrasound cardiograms (UCG) and signal-averaged electrocardiograms (SAECG) were recorded in the two groups both preceding and following the BSCT. There were no statistical intergroup or intragroup differences in left ventricular (LV) dimensions or contractile function. Significant (P<0.01) posttransplant increases in interventricular septal wall thickness and Ap/Ep ratio were noted in group A. Moreover, the filtered QRS duration as estimated by SAECG was prolonged (P<0.05) whereas the summated LV voltage (S V1 +R V5 ) was reduced in the posttransplant period only in group A. These results suggest that early cyclophosphamide cardiotoxicity was characterized by LV diastolic rather than systolic dysfunction. These findings may contribute to acute hemodynamic deterioration observed after cyclophosphamide-containing conditioning chemotherapy. (Jpn Heart J 2002; 43: 249-261)

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Section: Discussionmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction Induced by Cyclophosphamide in Blood Stem Cell Transplantation.

Mori

Yanagi

Maruyama³

et al. 2002

Jpn Heart J

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show abstract

“…The images were obtained through the use of harmonic imaging mode, which is able to determine an improvement of 2D image quality. 12 A detailed IBS methodology was used, as previously described. 9 Other important control settings of the imaging chain such as preprocessing, focus position, persistence, compression, frame rate, and postprocessing were maintained constant for all patients, accurately avoiding the signal saturation (ie, backscatter value sampled at maximum value for the dynamic range of the system) at every level (pericardium, valve, myocardium) for the possibility of estimation errors.…”

Section: Acoustic Densitometrymentioning

confidence: 99%

Severe Aortic Stenosis and Myocardial Function

et al. 2004

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Background— The aim of this study was to assess the myocardial reflectivity pattern in severe aortic valve stenosis through the use of integrated backscatter (IBS) analysis. Patients with aortic stenosis (AS) were carefully selected in the Department of Cardiology. Methods and Results— Thirty-five subjects (AS: valve orifice ≤1 cm 2 ; 12 female; mean age, 71.8±6.2 years) and 25 healthy subjects were studied. All subjects of the study had conventional 2D-Doppler echocardiography and IBS. Backscatter signal was sampled at the septum and posterior wall levels. Patients with AS were divided into 2 groups: 16 patients with initial signs of congestive heart failure and a depressed left ventricular systolic function (DSF) (ejection fraction [EF] range, 35% to 50%) and 19 asymptomatic patients with normal left ventricular systolic function (NSF) (EF >50%). Myocardial echo intensity (pericardium related) was significantly higher at the septum and posterior wall levels in DSF than in NSF and in control subjects. IBS variation, as an expression of variation of the signal, appeared to be significantly lower in AS with DSF than in NSF and in control subjects, at both the septum and posterior wall levels. Patients with DSF underwent aortic valve replacement, and, during surgical intervention, a septal myocardial biopsy was made for evaluation of myocardium/fibrosis ratio. Abnormally increased echo intensity was detected in left ventricular pressure overload by severe aortic stenosis and correlated with increase of myocardial collagen content (operating biopsy). Conclusions— One year after aortic valve replacement, we observed a significant reduction of left ventricular mass, and, only if pericardial indexed IBS value (reduction of interstitial fibrosis) decreased, it was possible to observe an improvement of EF and of IBS variation.

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“…Quality of echo images is difficult to assess in an objective fashion, but it was not better in the hand-carried device than in the standard machine, probably due to the difference in the display size. Better quality of echo images makes the examiner comfortable, and tissue harmonic imaging, if loaded, might help in this context in the near future [4][5][6]. Valve regurgitation.…”

Section: Standard Echo Total Reg (+)mentioning

confidence: 99%

Hand-Carried Echocardiography in Assessing Ventricular Function and Valvular Regurgitation

et al. 2004

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Use of harmonic imaging without echocardiographic contrast to improve two-dimensional image quality

Cited by 158 publications

References 18 publications

Left Ventricular Diastolic Dysfunction Induced by Cyclophosphamide in Blood Stem Cell Transplantation.

Left Ventricular Diastolic Dysfunction Induced by Cyclophosphamide in Blood Stem Cell Transplantation.

Severe Aortic Stenosis and Myocardial Function

Hand-Carried Echocardiography in Assessing Ventricular Function and Valvular Regurgitation

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