Use of methadone

Anderson, Ilene B.; Kearney, Thomas E.

doi:10.1136/ewjm.172.1.43

Cited by 45 publications

(51 citation statements)

References 29 publications

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“…Screening was performed for hepatitis B, C and, HIV in all cases. If possible, replacement therapy was progressively reduced in the second trimester of pregnancy to achieve minimal doses in the third trimester [13,14].…”

Section: Mothersmentioning

confidence: 99%

Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone

et al. 2007

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This hospital morphine solution is adequate for management of NAS. Preparations showed good stability and doses could be adjusted with a margin of 0.02 mg. The onset of NAS occurred within 24 h after birth in methadone-exposed infants (range 6-24 h) and within 48 h after birth in buprenorphine-exposed infants (range 24-168 h). Due to the possibility of delayed onset of NAS up to 7 days, infants born to mothers treated with buprenorphine should be kept in the hospital for an appropriate surveillance period. Treatment time was significantly longer (45 vs. 28 days) and the mean morphine doses were higher (1.7 fold) in methadone-exposed than buprenorphine-exposed infants.

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Section: Mothersmentioning

confidence: 99%

Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone

et al. 2007

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“…In such cases, it is important to note the time of the last dose, because the sedation can be expected to worsen for many hours after that dose (Modesto-Lowe et al, 2010). Similarly, when an overdose is diagnosed and treated, it is important to monitor the patient for at least 48 hours because the period of toxicity can extend to many hours or even days (Anderson and Kearney, 2000).…”

Section: Avoid Overdosementioning

confidence: 99%

Safe Methadone Induction and Stabilization

Baxter

Campbell

DeShields

et al. 2013

Journal of Addiction Medicine

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“…In 2006, Drug and Alcohol Services Information System reported that in 2005, 235,836 persons received methadone either for opiate detoxification or maintenance [Drug and Alcohol Services Information System, 2006 http://www.oas.samhsa.gov/2k6/otp/ otp.htm]. Methadone's primary mechanism of action is as a mu-receptor agonist that may work as an antagonist at the NMDA receptor [Anderson et al 2000;Roxane Laboratories, 2003]. Methadone is lipophilic and has unpredictable pharmacokinetics with large patient variability in absorption, bioavailability, peak concentration and half-life.…”

Section: Methadonementioning

confidence: 99%

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem

Vieweg

Hasnain

Howland

et al. 2013

Therapeutic Advances in Psychopharmacology

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Abstract:We reviewed the literature and found 31 adult cases and 1 newborn case of methadone-associated QTc interval prolongation and/or torsade de pointes (TdP). Parametric statistics may not be useful in studying this issue because methadone-associated TdP is a very rare event and, hence, "an extreme outlier" consistent with scalable randomness. We may have to rely upon narrative medicine in the form of case reports with all its limitations and hazards to provide our best understanding. We report risk factors for methadone-associated QTc interval prolongation and TdP based on review of published case reports. We believe both drug manufacturers and the FDA would better serve our patients and inform clinicians if they more readily reported drug-induced outliers such as methadone-associated TdP using a case report format.

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Use of methadone

Cited by 45 publications

References 29 publications

Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone

Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone

Safe Methadone Induction and Stabilization

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem

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