“…In the field of modern in vitro neuroscience, a mainstay methodology to study network-level electrophysiological properties of neuronal cell ensembles relies on non invasive substrateintegrated matrices of microelectrodes (i.e., Microelectrode Arrays or MEAs) functioning as interfaces between neuronal cultures and electronic readout systems (Johnstone et al, 2010;Nam and Wheeler, 2011;Obien et al, 2015). Nowadays, MEAs are routinely deployed in a bulk of applications, spanning studies about network dynamics (Biffi et al, 2013;Li et al, 2007;Wagenaar et al, 2006), neuronal plasticity (Liu et al, 2012), and drug screenings (Johnstone et al, 2010;Robinette et al, 2011).…”