Use of Multiple Data Sources for Surveillance of Work-Related Chronic Low-Back Pain and Disc-Related Sciatica in a French Region

Fouquet, Natacha; Bodin, Julie; Chazelle, Émilie; Descatha, Alexis

doi:10.1093/annweh/wxy023

Cited by 11 publications

(9 citation statements)

References 40 publications

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“…A lot of research findings have shown that a significant decrease in the number of the cellular constituents in the degenerative intervertebral disc is one of the important reasons for extracellular substrate metabolism imbalance and decreased content [ 15 , 16 ] while apoptosis is the leading cause of the decreased number of the cells in the intervertebral disc [ 17 ]. Wu D et al have detected the apoptotic rate of the cells in the intervertebral disc of the patients with protrusion of intervertebral disc and discovered that the apoptotic rate is significantly higher than that in the healthy people [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Research on Roles of Mongolian Medical Warm Acupuncture in Inhibiting p38 MAPK Activation and Apoptosis of Nucleus Pulposus Cells

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Background Mongolian medical warm acupuncture has a desirable therapeutic effect on sciatica. Apoptosis of the nucleus pulposus cells is considered to play an important role in sciatica. Evidence has demonstrated that oxidative stress and its induced activation of the signaling pathways play important roles in sciatica. However, further research is expected to reveal whether Mongolian medical warm acupuncture can inhibit the apoptosis of nucleus pulposus cells and oxidative stress. Objective To study the effect of the p38 MAPK pathway activated by the generated ROS on apoptosis and the expression of the genes related to the balance of the extracellular matrix metabolism during treatment of sciatica with Mongolian medical warm acupuncture. Method The volume of the active oxygen generated in the nucleus pulposus cells was detected following intervention of Mongolian medical warm acupuncture. The p38 MAPK phosphorylation level was detected with Western blot. The genes are related to the metabolism of the nucleus pulposus extracellular matrix. Result Mongolian medical warm acupuncture reduced the active oxygen within the nucleus pulposus cells and inhibited the activation of the p38 MAPK pathway (P=0.013). Meanwhile, it upregulated the gene expression of Type II collagen, aggrecan, Sox-9, and tissue matrix metalloproteinase reagent 1 (P-0.015; P=0.025; P=0.031; P=0.045) and downregulated the gene expression of matrix metalloproteinase 3 (P=0.015). Conclusion Mongolian medical warm acupuncture may inhibit apoptosis of nucleus pulposus cells and activation of the extracellular matrix decomposition metabolism pathway and promote its anabolism. This process may rely on the oxidative stress matrix of the p38 MAPK pathway.

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Section: Discussionmentioning

confidence: 99%

Research on Roles of Mongolian Medical Warm Acupuncture in Inhibiting p38 MAPK Activation and Apoptosis of Nucleus Pulposus Cells

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Health systems are different in each country. The differences in the treatment of occupational ailments distort occupational risk prevention systems (India, Australia, Finland, Italy, South Korea, USA, France, Canada and the Netherlands) [81,141,175,[184][185][186][187][188][189][190][191][192][193][194][195][196][197][198][199]. Preventive measures, the type of crop and the permissiveness of the authorities are factors that affect this distortion (USA and Europe) [95,147,200].…”

Section: Msd Studies In Agriculturementioning

confidence: 99%

Musculoskeletal Disorders in Agriculture: A Review from Web of Science Core Collection

et al. 2021

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Agricultural workers suffer from many work-related illnesses. Some of the most common include musculoskeletal disorders (MSDs). These types of disorders are caused by diverse factors. This research study intends to demonstrate the worldwide concern for MSD in agriculture. The objective is to compile and recognize in detail all the available studies on musculoskeletal disorders in agriculture developed in the world and by countries in the last 26 years. The Web of Science database was used for this purpose. Two hundred and fifty-six documents were found, of which 221 were finally selected for inclusion in the study. The studies span a period from 1995 to 2020. Of these, studies that were linked to improving sustainability stood out. Most of the research of this type emanates from developed countries. The conclusions to be drawn are that few countries pay attention to this area and that preventive measures are insufficient. Mechanization and improvement in work methods and organization are methods to reduce risks.

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“…industry sectors were at high risk of LDS in the region, amounting to 277 [216-352] LDS cases, of which 98 [37-175] were WR-LDS (Table 1): construction and information & communication for men; wholesale & retail trade and accommodation & food service activities for women. AFE was limited for each industry sector, varying between 30% for men construction and 55% for women of accommodation & food service activities.As shown inTable 2, the number of avoidable LDS varied between the different preventive scenarios and sectors.The 10%-WI, 5%-GI and 10%-GI scenarios hypothetically prevented 10[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], 13[11][12][13][14][15][16][17] and 28[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] LDS cases among sectors at risk, respectively. For each sector at risk, the hypothetical preventive efficiency was lower for the 10%-WI scenario compared to the 10%-GI and even the 5%-GI scenarios.…”

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confidence: 99%

“…Surveillance data used for the computation of potentially preventable LDS included data from one of the largest and most complete surveillance programs for LDS, covering an entire region of France[22,30]. The French PMSI database registering only LDS underestimated cases potentially preventable since disc-related sciatica (DRS) requiring only medical treatment and more generally LBP were not counted.…”

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confidence: 99%

Theoretical impact of workplace-based primary prevention of lumbar disc surgery in a French region: A pilot study

Fouquet

Petit

Descatha

2019

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Background: Lumbar disc-related disorders are a main cause of work-related osteo-articular morbidity. Lumbar disc surgery (LDS) has been chosen as sentinel event for the epidemiological surveillance of these disorders since LDS can be identified in the medical databases from public and private hospitals. Objective: To assess the theoretical impact of workplace-based primary interventions designed to reduce exposure to personal and/or workrelated risk factors for LDS. Methods: Cases of LDS were assessed using hospital discharge records for persons aged 20-64 in 2007-8 in the French Pays de la Loire region. We estimated the number of work-related cases of LDS (WR-LDS) in high-risk industry sectors. Three theoretical scenarios of workplace-based primary prevention have been simulated: a mono-component work-centered intervention reducing the incidence of WR-LDS by 10%, and two multicomponent global interventions reducing the incidence of all cases of LDS by 5% and 10% by targeting personal and occupational risk factors. Results: Four high-risk sectors were identified, amounting to 277 [216-352] cases, of which 98 [37-175] were WR-LDS: construction and information & communication for men; wholesale & retail trade and accommodation & food service activities for women. AFE was limited for each industry sector, 30%, 50%, 33% and 55%, respectively. Conclusions: Prevention scenarios combining actions on personal and occupational risk factors would be the most effective, compared to prevention focused only on occupational risk factors. Implementing actions of promotion of health at work would be necessary in addition of actions on occupational risks.

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Use of Multiple Data Sources for Surveillance of Work-Related Chronic Low-Back Pain and Disc-Related Sciatica in a French Region

Abstract: The results showed the complementarity of the four surveillance programs. A multi-component surveillance system allowed detection of industry sectors most in need of prevention programs.

Cited by 11 publications

References 40 publications

Research on Roles of Mongolian Medical Warm Acupuncture in Inhibiting p38 MAPK Activation and Apoptosis of Nucleus Pulposus Cells

Research on Roles of Mongolian Medical Warm Acupuncture in Inhibiting p38 MAPK Activation and Apoptosis of Nucleus Pulposus Cells

Musculoskeletal Disorders in Agriculture: A Review from Web of Science Core Collection

Theoretical impact of workplace-based primary prevention of lumbar disc surgery in a French region: A pilot study

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