Use of Optical Biosensor Technology to Study Immunological Cross-Reactivity between Different Sulfonamide Drugs

Ahmad, Ateeq; Ramakrishnan, Anand; McLean, Matthew A.; Li, Dongbei; Rock, Marie; Karim, Aziz; Breau, Alan P.

doi:10.1006/abio.2001.5467

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…28 A biosensor was used to test the binding of sulfamethazine and furosemide to antisulfamethazine or antifurosemide antibody in the presence of other structurally related sulfonamides. A total of 13 other sulfonamides were tested for cross-reactivity.…”

Section: Verdel Et Almentioning

confidence: 99%

Sulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?

Wulf

Matuszewski

2013

American Journal of Health-System Pharmacy

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Section: Verdel Et Almentioning

confidence: 99%

Sulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?

Wulf

Matuszewski

2013

American Journal of Health-System Pharmacy

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“…12 The 5-methyl-3isoxazoyl heterocyclic ring at the N1 position (the sulfonamide nitrogen) was the allergenic determinant since the sulfonamide antibiotics that contained this group had the strongest affinity for immunoglobulin E. In immunologic studies, serum-derived antibodies against sulfamethazine were tested against sulfonamide nonantibiotics, including HCTZ. 13 The results showed no reactivity of the antibodies with any of the tested drugs.…”

Section: Discussionmentioning

confidence: 89%

Severe Allergic Reaction to Hydrochlorothiazide Mimicking Septic Shock

Mineo

Cheng

2009

Pharmacotherapy

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Hydrochlorothiazide (HCTZ) is a sulfonamide-containing drug with commonly reported adverse effects that include electrolyte abnormalities, orthostatic hypotension, hyperglycemia, and photosensitivity. A few reports have described rare but serious drug complications such as interstitial pneumonitis, angioedema, and aplastic anemia. We describe a patient who experienced a serious HCTZ-induced adverse event that, to our knowledge, has not yet been reported in the literature. A 78-year-old woman came to the emergency department with dyspnea and severe fatigue; her signs and symptoms were suggestive of septic shock from pneumonia. She was treated accordingly, her condition improved, and she was discharged home. During the next 2 months, the patient returned to the emergency department 2 more times and was hospitalized each time with the same diagnosis. During her third admission, it was discovered that the patient's primary care physician had restarted her HCTZ for hypertension after it had been discontinued during each of the first two hospitalizations. The patient's symptoms began within hours of the first and second hospitalizations and almost immediately after taking a dose of HCTZ on the day of the third hospitalization. Her medical history revealed documented allergic reactions to sulfonamide drugs and penicillin; thus a hypersensitivity reaction to HCTZ was suspected. Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship between the patient's hypersensitivity reactions and HCTZ therapy. Because of a lack of evidence showing cross-reactivity among the different classes of sulfonamides, the mechanism of the allergic reaction to HCTZ was unlikely to be cross-sensitivity between sulfonamide antibiotics and sulfonamide nonantibiotic drugs. Although the mechanism is not clear, evidence shows that the allergy to the HCTZ (sulfonamide nonantibiotic) may be due to a predisposition to drug allergies rather than sulfonamide cross-sensitivity. Clinicians should be aware of the potential for these types of allergic reactions.

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“…Therefore, most of the biosensors developed are aimed at determining them in biological or food samples. For example, a commercial biosensor BIACORE 3000 was used to study the cross-reactivity between two sulfonamides (a group of antibiotics): sulfamethazine and furosemide [82]. Sulfonamides sometimes cause allergic reactions, whereas their effect in the human inmunosystem is of high interest for their therapeutical application.…”

Section: Antibioticsmentioning

confidence: 99%

“…The BIACORE 3000 biosensor, which is based on SPR principle, monitors biomolecular interactions as they proceed over time. The advantage of the method is that there is no need for labeling the interactants [82]. Approximately 90 % of the 1998 and 1999 commercial biosensor publications cite the use of BIACORE instruments [137].…”

Section: Commercial Biosensorsmentioning

confidence: 99%

Biosensors for environmental applications: Future development trends

Rodríguez-Mozaz

Marco

Alda

et al. 2004

Pure and Applied Chemistry

199

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Biosensors can be excellent analytical tools for monitoring programs working to implement legislation. In this article, biosensors for environmental analysis and monitoring are extensively reviewed. Examples of biosensors for the most important families of environmental pollutants, including some commercial devices, are presented. Finally, future trends in biosensor development are discussed. In this context, bioelectronics, nanotechnology, miniaturization, and especially biotechnology seem to be growing areas that will have a marked influence on the development of new biosensing strategies in the next future.

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Use of Optical Biosensor Technology to Study Immunological Cross-Reactivity between Different Sulfonamide Drugs

Cited by 16 publications

References 5 publications

Sulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?

Sulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?

Severe Allergic Reaction to Hydrochlorothiazide Mimicking Septic Shock

Biosensors for environmental applications: Future development trends

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