Use of two detection methods to discriminate ciguatoxins from brevetoxins: Application to great barracuda from Florida Keys

Dechraoui, M. Yasmine Bottein; Tiedeken, Jessica A.; Persad, Renuka; Wang, Zhihong; Granade, Hudson R.; Dickey, Robert; Ramsdell, John S.

doi:10.1016/j.toxicon.2005.04.006

Cited by 97 publications

(74 citation statements)

References 35 publications

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“…Over the past decade, again thanks to the application of new technologies, major advances have been made in the detection of brevetoxins in a range of substrates, including seawater, air, seafood, and various animal and human clinical specimens (Dechraoui 2005; Dickey et al, 2004; Flewelling et al, 2005; Naar et al, 2007; Plakas et al, 2008; Poli et al, 2007; Weidner et al, 2004; Woofter et al 2003, 2005a and b, 2007). In particular, the creation, development and application of a new brevetoxin ELISA to all of these substrates, coupled with significant improvements in the detection limits of more traditional toxicologic analyses (e.g.…”

Section: 0 Toxinsmentioning

confidence: 99%

Review of Florida red tide and human health effects

et al. 2011

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This paper reviews the literature describing research performed over the past decade on the known and possible exposures and human health effects associated with Florida red tides. These harmful algal blooms are caused by the dinoflagellate, Karenia brevis, and similar organisms, all of which produce a suite of natural toxins known as brevetoxins. Florida red tide research has benefited from a consistently funded, long term research program, that has allowed an interdisciplinary team of researchers to focus their attention on this specific environmental issue—one that is critically important to Gulf of Mexico and other coastal communities. This long-term interdisciplinary approach has allowed the team to engage the local community, identify measures to protect public health, take emerging technologies into the field, forge advances in natural products chemistry, and develop a valuable pharmaceutical product. The Review includes a brief discussion of the Florida red tide organisms and their toxins, and then focuses on the effects of these toxins on animals and humans, including how these effects predict what we might expect to see in exposed people.

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Section: 0 Toxinsmentioning

confidence: 99%

Review of Florida red tide and human health effects

et al. 2011

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“…CTXs are lipophilic polyether compounds that may undergo bio-accumulation and biotransformation into more polar compounds with possible biomagnification along the food chain from herbivorous grazers to carnivorous fish that feed on them. CTXs are potent voltage gated sodium channel (VGSC) activating toxins responsible of the majors symptoms produced during CFP but implication of others toxins in ciguatera is also supposed (Dechraoui et al, 2005;Kirkpatrick et al, 2004;Laurent et al, 2008). Dinoflagellates of the genera Prorocentrum, Ostreopsis, Coolia and Amphidinium coexist with Gambierdiscus spp.…”

Section: Introductionmentioning

confidence: 99%

“…Many methodological approaches have been used for the determination of CTXs such as bioassays with animals like the mouse bioassay (MB) (Banner et al, 1961;Lewis and Sellin, 1992;Yasumoto et al, 1984); instrumental analytical methods (Dickey et al, 1992;Legrand et al, 1989;Lewis et al, 1999Lewis et al, , 2009); immunoassays (Campora et al, 2008a(Campora et al, , 2008bHokama et al, 1998); pharmacological assays like the radio binding assay (RBA) (Darius et al, 2007;Dechraoui et al, 2005;Van Dolah et al, 1994) as well as in vitro cell based assay (CBA) (Campora et al, 2008a;Cañ ete and Diogè ne, 2010;Dechraoui et al, 2005;Dickey et al, 1999;Manger et al, 1995Manger et al, , 1993. A comprehensive update on methodologies available for ciguatoxin determination has been recently reviewed (Caillaud et al, 2010a).…”

Section: Introductionmentioning

confidence: 99%

Monitoring of dissolved ciguatoxin and maitotoxin using solid-phase adsorption toxin tracking devices: Application to Gambierdiscus pacificus in culture

et al. 2011

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“…This test shows high sensitivity and specificity for screening purposes (Caillaud et al, 2012;Pawlowiez et al, 2013;Dechraoui et al, 1999Dechraoui et al, , 2005, and has proven useful for monitoring toxin levels in blood in laboratory rodents and wildlife.…”

Section: Functional Biochemical and Biomolecular Assaysmentioning

confidence: 99%

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

Daneshian

2013

ALTEX

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Summary Aquatic food accounts for over 40% of global animal food products, and the potential contamination with toxins of algal origin -marine biotoxins -poses a health threat for consumers. The gold standards to assess toxins in aquatic food have traditionally been in vivo methodssingle marine biotoxins or combinations of marine biotoxins and intoxication symptomatology as well as monitoring the "success" of controls implemented during fishery and aquaculture production, processing, and retailing. For this reason, a workshop was organized in ermatingen, Switzerland by the Center for Alternatives to Animal testing -europe (CAAteurope) within the framework of the transatlantic think tank for toxicology (t 4 ).In contrast to other food products where hygiene and potential contamination with microbes or mold toxins is the prime issue, the emphasis in aquatic products (shellfish and finfish) is, beyond viral and bacterial contaminations, primarily placed on potential contamination with marine biotoxins owing to the numerous and recurring human intoxications.The gold standards to assess toxins in aquatic food have traditionally been in vivo methods, i.e., the mouse and the rat bioassays. Besides the ethical issues of in vivo bioassays there are specific difficulties, e.g., different exposure route (i.p. versus oral), low inter-species comparability, high intra-species variability, and questionable extrapolation of quantitative risk to humans, thus highlighting the need for the development of more reliable detection and quantification methods. Based on this reasoning, the european Food Safety Authority (eFSA) advocates the use of an analytical method, i.e., LC-MS (Liquid Chromatography coupled Mass Spectrometry), as a substitute for in vivo bioassays for almost all classes of marine toxins. However, although lC-MS is a very sensitive method that has the advantages of being able to detect multiple toxins in a single analysis and being good for confirming the identity of toxins, the quality of quantitative analysis is dependent on the availability of calibration standards. While many new toxin structural analogues have been detected and identified using LC-MS, this technique -as with most other methods -is not good at detecting new toxin types. When new toxin analogues are detected but accurate standards are not yet available, only an approximate quantitation is possible using estimated response factors.For the purpose of risk assessment of food, however, it is imperative to focus on the possible adverse effects, independent of whether they stem from one toxin or a combination of toxins. As toxicity is defined by functional and structural changes of biological systems, the development of a human-relevant in vitro system for appropriate risk assessment of marine biotoxins in seafood stands to reason. Moreover, poor correlation of human intoxications, of acute symptomatology and long-term adverse effects, and of predictive in vitro, in vivo, and analytical detection methodologies of marine biotoxins stems not least from a...

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Use of two detection methods to discriminate ciguatoxins from brevetoxins: Application to great barracuda from Florida Keys

Cited by 97 publications

References 35 publications

Review of Florida red tide and human health effects

Review of Florida red tide and human health effects

Monitoring of dissolved ciguatoxin and maitotoxin using solid-phase adsorption toxin tracking devices: Application to Gambierdiscus pacificus in culture

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

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