Usefulness of a Nanoparticle Formulation to Investigate Some Hemodynamic Parameters of a Poorly Soluble Compound

NanoClusters Surface Area Allows Nanoparticle Dissolution with Microparticle Properties

“…Some strategies use polymer systems that dissolve with time to create a porous network of channels throughout the dosage form to increase the amount of water available to contact the poorly water‐soluble drug surface . Other methods use excipients to create emulsions, combine liquids with powder forming liquisolid samples, or to add wetting agents to improve disintegration of the solid dosage form …”

“…One such top down technology is called NanoCrystal®, where the drug compound is milled with surfactants to create and maintain individual nanoparticles in an effort to achieve more rapid dissolution . The strategy behind many of these techniques is to decrease particle size to increase surface area . One potential issue with using surfactants is that surfactants can have side effects in patients …”

“…7,8,11 Some strategies use polymer systems that dissolve with time to create a porous network of channels throughout the dosage form to increase the amount of water available to contact the poorly water-soluble drug surface. 12,13 Other methods use excipients to create emulsions, 10,14,15 combine liquids with powder forming liquisolid samples, 16,17 or to add wetting agents to improve disintegration of the solid dosage form. 7,8,11,18 Besides different formulation strategies, there has also been a surge in technologies to increase dissolution by manipulating the size of drug particles.…”

“…7,8,11,18 Besides different formulation strategies, there has also been a surge in technologies to increase dissolution by manipulating the size of drug particles. 18 There are bottom-up methods including precipitation, solid dispersions, 5,7,19 spray drying and spray freezing into liquid, 4,5,15,[20][21][22] as well as top-down methods such as homogenization and milling. 3,15,22,23 Some bottomup methods including precipitation can involve cosolvents, 16 which add the burden of solvent removal and disposal after processing and before use by patients.…”

“…18 There are bottom-up methods including precipitation, solid dispersions, 5,7,19 spray drying and spray freezing into liquid, 4,5,15,[20][21][22] as well as top-down methods such as homogenization and milling. 3,15,22,23 Some bottomup methods including precipitation can involve cosolvents, 16 which add the burden of solvent removal and disposal after processing and before use by patients. 24 Spray drying allows more precise control of particle size but may be an issue if the product is thermally labile.…”