Usefulness of Cefovecin Disk‐Diffusion Test for Predicting Meca Gene‐Containing Strains of Staphylococcus Pseudintermedius and Clinical Efficacy of Cefovecin in Dogs with Superficial Pyoderma

Canine superficial bacterial pyoderma: evaluation of skin surface sampling methods and antimicrobial susceptibility of causalStaphylococcusisolates

“…Cefovecin, however, has previously demonstrated good activity against Staphylococcus spp and S. pseudintermedius isolates in studies using broth microdilution methods to determine the minimum inhibitory concentration . It should be noted that the disk diffusion susceptibility diameter for cefovecin in our study was selected as result of recent work published by Iyori et al; however, further evaluation of susceptibility diameter based on a larger number of bacterial species may be required to establish accuracy.…”

“…Using the Clinical Laboratory Standards Institute's disk diffusion standards and interpretive guidelines M31‐A3, isolates underwent antimicrobial susceptibility testing against amoxycillin/clavulanic acid (20 μg/10 μg), cephalexin (30 μg), cephalothin (30 μg), cefovecin (30 μg), cefoxitin (10 μg), penicillin (10 U), chloramphenicol (10 μg), doxycycline (30 μg), enrofloxacin (5 μg), erythromycin (15 μg), clindamycin (2 μg), gentamicin (10 μg), oxacillin (1 μg) (used to determine methicillin resistance in vitro), and trimethoprim/sulfamethoxazole (1.25 μg/23.75 μg). Disk diffusion susceptibility diameter for cefovecin was set at >27 mm as indicated by Iyori et al . and at ≥31 mm for cefoxitin as suggested by Bemis et al .…”