Usefulness of Cellular Text Messaging for Improving Adherence Among Adolescents and Young Adults with Systemic Lupus Erythematosus

Abstract

Patients with cSLE were only modestly adherent to HCQ and clinic visits. CTMR may be effective for improving visit adherence among adolescents and young adults with cSLE, but it does not improve adherence to HCQ.

What are the effects of medication adherence interventions in rheumatic diseases: a systematic review

“…Study details along with intervention classifications are in online supplementary table S3. The description of interventions ranged from ‘one-on-one instruction’,25 ‘group education’,26 ‘telephone-based pharmacy advisory’,27 to ‘text message reminders’ 28. Fourteen of 23 interventions were designed to directly target medication adherence, with all but one intervention29 directed at patients with rheumatology.…”

Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study)

“…In a previous study, we found that 7% of 203 patients with SLE were non-adherent,14 and this proportion increased to 30% when the analysis was restricted to patients with active SLE (SELENA-SLEDAI ≥12). Recently, Ting et al 15 found that 29% of adolescents and young adults with SLE were non-adherent, as defined by undetectable [HCQ], and that medication adherence estimates using [HCQ] correlated with adherence rates obtained from pharmacy refill information (Pearson correlation coefficient r=0.50, p<0.0001). One of the main causes of treatment failure in patients with chronic diseases, including SLE, is the lack of adherence to treatment, especially among younger patients 16.…”

Reply

“…Using an undetectable blood HCQ concentration as a measure of compliance, Ting et al observed that 29% of adolescents and young adults with SLE were nonadherent (5). Medication adherence as estimated using blood HCQ concentrations correlated with adherence rates as measured using pharmacy refill information (5).…”