1998
DOI: 10.1016/s0002-9149(97)01021-7
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Usefulness of Enhanced Insulin Secretion During an Oral Glucose Tolerance Test as a Predictor of Restenosis After Direct Percutaneous Transluminal Coronary Angioplasty During Acute Myocardial Infarction in Patients Without Diabetes Mellitus

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Cited by 28 publications
(21 citation statements)
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“…1,2 These events are exacerbated in insulin-resistant states. [3][4][5] It is controversial whether increased plasma insulin concentrations resulting from insulin resistance contributes to vascular pathology. 20,21 Another view is that insulin actually ameliorates vascular disease and that the functional lack of insulin in insulin-resistant states contributes to deleterious VSMC behavior.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…1,2 These events are exacerbated in insulin-resistant states. [3][4][5] It is controversial whether increased plasma insulin concentrations resulting from insulin resistance contributes to vascular pathology. 20,21 Another view is that insulin actually ameliorates vascular disease and that the functional lack of insulin in insulin-resistant states contributes to deleterious VSMC behavior.…”
Section: Discussionmentioning
confidence: 99%
“…1,2 Increased atherosclerosis and restenosis occur in patients with insulin-resistant states, [3][4][5] raising the possibility that a functional lack of insulin contributes to increased vascular disease in humans. This hypothesis is consistent with our previous report, which demonstrated that if cultured canine VSMCs had been induced to express inducible nitric oxide synthase (iNOS), insulin stimulated cGMP production, which in turn inhibited cell migration in a wound closure assay.…”
mentioning
confidence: 99%
“…Insulin-resistant states are associated with accelerated vascular disease. [1][2][3] The failure of insulin to stimulate guanylate cyclase in the vascular smooth muscle of these individuals could contribute to their vascular pathology. Alternatively, it has been proposed that the hyperinsulinemia associated with those conditions can aggravate it.…”
Section: Perspectivesmentioning
confidence: 99%
“…Key Words: muscle, smooth, vascular Ⅲ insulin Ⅲ cyclic GMP Ⅲ nitric oxide A therosclerosis and restenosis after balloon catheter angioplasty are increased in insulin-resistant states. [1][2][3] Some studies support the view that hyperinsulinemia, which is present in these conditions, stimulates vascular smooth muscle cell (VSMC) migration and proliferation, thereby accelerating the pathological process. 4,5 Other data show that insulin can stimulate cGMP accumulation in normal cultured VSMCs 6,7 and that cGMP inhibits migration and proliferation of those cells.…”
mentioning
confidence: 99%
“…nsulin resistance, which occurs in obesity, non-insulindependent diabetes mellitus, and essential hypertension, is associated with increased atherosclerosis and restenosis after balloon angioplasty, [1][2][3] but the reasons for this are obscure. The migration of vascular smooth muscle cells (VSMCs) from the arterial media through the internal elastic membrane into the neointima is an integral part of the pathogenesis of atherosclerosis and restenosis.…”
mentioning
confidence: 99%