Usefulness of sentinel lymph node detection in early stages of cervical cancer

Roca, Isabel; Caresia, Ana Paula; Gil‐Moreno, Antonio; Pifarré, P.; Aguadé-Bruix, Santiago; Castell-Conesa, Joan; Martínez-Palones, José M.; Xercavins, Jordi

doi:10.1007/s00259-005-1834-8

Cited by 31 publications

(14 citation statements)

References 28 publications

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“…SN procedure. SN procedure was performed in accordance with previous studies using combined radiocolloid and colorimetric technique [7,9,12,13]. The position of each SN relative to the major pelvic vessels, and the count rate, were recorded.…”

Section: Patients and Methods Patientsmentioning

confidence: 99%

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Coutant¹,

Barranger²,

Cortez

et al. 2007

Annals of Oncology

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Background: It has been suggested that histologically undetectable or 'occult' metastases in the lymphatic system could explain some recurrences. HPV DNA screening by means of the polymerase chain reaction (PCR) has been proposed as a method to detect occult metastases. This study was designed to determine the frequency of HPV DNA detection by PCR in sentinel lymph node (SN), and its relation to the clinical characteristics and outcome of women with cervical cancer. Patients and methods:The primary cervical tumor and SN were tested for HPV DNA by means of PCR in 59 patients.Results: Fifteen (25.4%) of the 59 women undergoing the SN procedure had an involved SN. HPV DNA was more frequent in positive SN than in negative SN (P < 0.0001). Seven patients had a recurrence, after a mean delay of 17 months (range: 10-26). One of seven patients with a recurrence had an involved SN. HPV DNA was detected in an SN of one of seven patients with recurrence and nine (19.5%) of 46 patients without recurrence (not significant). Conclusion:In women with cervical cancer, HPV DNA screening of sentinel nodes might help to identify patients at risk of lymph node metastases and recurrence.

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Section: Patients and Methods Patientsmentioning

confidence: 99%

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Coutant¹,

Barranger²,

Cortez

et al. 2007

Annals of Oncology

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“…For the remaining studies, the full text was read. Finally, a total of 17 studies were included in the analysis, involving a total of 1,112 patients (5,6,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). The study selection process is summarized in Fig.…”

Section: Study Selection and Descriptionmentioning

confidence: 99%

Sentinel lymph node biopsy in cervical cancer: A meta-analysis

et al. 2013

Molecular and Clinical Oncology

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Abstract. Sentinel lymph node biopsy (SLNB) is used to determine the pathological status of the first lymph node receiving lymphatic drainage from the primary tumor. The diagnostic value of SLNB for the assessment of the nodal status in patients with cervical cancer has not been determined. Therefore, this meta-analysis was conducted to assess the diagnostic value of SLNB in cervical cancer. A search for related literature was performed using PubMed. Data were analyzed using a random effects model and a subgroup analysis was used to assess the diagnostic value of different practices during the process. A total of 17 studies involving a total of 1,112 patients were included in the analysis. The pooled sentinel lymph node (SLN) detection rate, sensitivity and negative predictive values were 92.2% [95% confidence interval (CI): 88.3-94.8%], 88.8% (95% CI: 85.1-91.7%) and 95.0% (95% CI: 92.8-96.6%), respectively. The subgroup analysis revealed that laparoscopy, tracer combination and immunohistochemistry were associated with a higher SLN detection rate. In conclusion, the SLNB in cervical cancer appears to be of diagnostic value, particularly the procedure with the combination of laparoscopy, combined tracers and immunohistochemistry. However, further studies are required to establish the clinical value of SLNB in cervical cancer.

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“…5,9,28,34,39,40 Twenty-one of the thirty-seven SLN studies reviewed during the preparation of this series reported a 0% false negative rate. [1][2][3][4]6,7,11,12,17,18,21,22,26,27,29,31,32,36,40,42,44 In the remaining 12 studies, in which the issue of the false negative rate was addressed, the reported false negative rate ranged from 2.8% to 37%. 5,8,16,20,23,24,28,30,34,35,37,39 The widely ranging false negative rates in these studies (0% to 37% overall) are most likely reflections of the variation in SLN identification technique and the variation in the histopathologic examination of the SLNs.…”

Section: Discussionmentioning

confidence: 92%

“…33,45 The feasibility of SLN identification in cervical carcinoma has been well documented. [1][2][3][4][5][6][7][9][10][11][12][13][16][17][18][20][21][22][23][24][25][26][27][28][29][30][31][32][34][35][36][37]39,40,[42][43][44] The majority of these studies have focused on the clinical process of SLN identification and the predictive value of the SLN result. Many of these series have been relatively small with a tendency to include all types of cervical carcinoma.…”

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confidence: 99%

Ultrastaging Improves Detection of Metastases in Sentinel Lymph Nodes of Uterine Cervix Squamous Cell Carcinoma

Euscher¹,

Malpica²,

Atkinson

et al. 2008

American Journal of Surgical Pathology

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The technique of sentinel lymph node (SLN) detection is increasingly being applied in patients with uterine cervix carcinoma. This study presents the pathologic findings of SLNs in 48 such patients. The institutional pathology files were searched for all patients with a diagnosis of cervical squamous cell carcinoma who had SLNs reported. Patient age, follow-up, tumor size, presence/absence of lymphatic invasion, number and status of SLNs and non-SLNs, location of SLNs, and size of metastases in SLNs were recorded. All SLNs were sectioned in 2-mm slices perpendicular to the long axis and submitted entirely for microscopic examination. For all SLNs negative on the initial hematoxylin and eosin (H&E) stained slides, an ultrastaging protocol was performed consisting of 5 sets of slides at 40-mum intervals (1 H&E slide+2 unstained slides), representing an additional 5 intervals. Lymph nodes negative by the additional H&E intervals had immunohistochemistry for cytokeratin performed on 1 unstained slide. Forty-eight patients ranging from 25 to 62 years of age had a total of 208 SLNs removed. Fifteen (31%) patients had positive SLNs with 1 to 5 positive SLNs per case. The metastasis size ranged from a single cell to 27 mm. Twelve patients had metastasis detected by routine processing in 23 SLNs, whereas ultrastaging detected metastases in 3 SLNs of 3 additional patients. In 2 patients with metastasis detected by ultrastaging, the metastasis was detected by wide H&E intervals (level 2 for 1 patient; level 3 for 1 patient); in 1 patient, the metastasis was detected only by immunohistochemistry and consisted of a single cell. Of the 15 patients with positive SLNs, 3 patients had a total of 6 positive non-SLNs. All of the patients with a positive SLN are currently living. Thirty-three (69%) patients had negative SLNs. Of these, 1 patient had a single positive non-SLN for a false negative rate of 6.25%. Negative SLN predicts negative non-SLN. For most patients with a positive SLN, the SLN will be the only metastasis detected; a minority of patients with a positive SLN may have a positive non-SLN.

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Usefulness of sentinel lymph node detection in early stages of cervical cancer

Cited by 31 publications

References 28 publications

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

Sentinel lymph node biopsy in cervical cancer: A meta-analysis

Ultrastaging Improves Detection of Metastases in Sentinel Lymph Nodes of Uterine Cervix Squamous Cell Carcinoma

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