User experience for manual injection of 2 mL viscous solutions is enhanced by a new prefillable syringe with a staked 8 mm ultra-thin wall needle

Pager, Aurélie; Combedazou, Anne; Guerrero, Karen; Tzvetkova-Chevolleau, Tzvetelina; Morel, Didier; Frolet, Cécile; Glezer, Stanislav

doi:10.1080/17425247.2020.1796630

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…Additionally, an innovative needle design will improve the flow rate tremendously. Shorter needles with ultra-thin wall design not only increase the net outflow, but also prevent intramuscular injection risk and injection-related anxiety [43,44]. In addition to designing a high-flow micropump, we would like to further evaluate the pumpmedium interaction.…”

Section: Discussionmentioning

confidence: 99%

Microfluidic Delivery of High Viscosity Liquids Using Piezoelectric Micropumps for Subcutaneous Drug Infusion Applications

Surendran,

Durasiewicz,

Hoffmann

et al. 2024

IEEE Open J. Eng. Med. Biol.

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Goal: Auto-injectors for self-administration of drugs are usually refrigerated. If not warmed up prior to the injection, ejection of the total drug volume is not guaranteed, as their spring and plunger mechanism cannot adjust for a change in viscosity of the drug. Here, we develop piezoelectric micro diaphragm pump that allows these modifications possible while investigating the effectiveness of this alternative dosing method. Methods: The dosing of highly viscous liquid of 25 mPa·s is made possible using application-specific micropump design. By comparing the analytical with experimental results, the practicality of the concept is verified. Results: Using a powerful piezoelectric stack actuator, the micropump achieves high fluid pressures of up to (368 ± 17) kPa. In order to assess the influence of viscosity, we characterize the fluidic performance of the designed micropump through 27G gauge needle for various water-glycerin mixtures. We find maximum flow rates of 2 mL/min for viscosities of up to 25 mPa·s. Conclusions: The developed micro diaphragm pump enables the development of smart auto-injectors with flow rate regulation to achieve drug delivery for high viscosity drugs through 27G needles.

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Section: Discussionmentioning

confidence: 99%

Microfluidic Delivery of High Viscosity Liquids Using Piezoelectric Micropumps for Subcutaneous Drug Infusion Applications

Surendran,

Durasiewicz,

Hoffmann

et al. 2024

IEEE Open J. Eng. Med. Biol.

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show abstract

“…However, electrospraying and microglassification may necessitate long development times and the use of non-aqueous solvents for administration. 40 Additionally, there are device strategies designed to facilitate the injection of higher-viscosity solutions, such as tapered needles, 52 needles with extremely thin walls to allow for a larger interior needle diameter without increasing the exterior diameter, 53 and devices with higher-pressure injectors. 5 …”

Section: Subcutaneous Formulation Considerationsmentioning

confidence: 99%

Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume

Desai,

Kundu,

Hageman

et al. 2023

mAbs

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Biologic drugs are used to treat a variety of cancers and chronic diseases. While most of these treatments are administered intravenously by trained healthcare professionals, a noticeable trend has emerged favoring subcutaneous (SC) administration. SC administration of biologics poses several challenges. Biologic drugs often require higher doses for optimal efficacy, surpassing the low volume capacity of traditional SC delivery methods like autoinjectors. Consequently, high concentrations of active ingredients are needed, creating time-consuming formulation obstacles. Alternatives to traditional SC delivery systems are therefore needed to support higher-volume biologic formulations and to reduce development time and other risks associated with high-concentration biologic formulations. Here, we outline key considerations for SC biologic drug formulations and delivery and explore a paradigm shift: the flexibility afforded by low-to-moderate-concentration drugs in high-volume formulations as an alternative to the traditionally difficult approach of high-concentration, low-volume SC formulation delivery.

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“…45 The options to select delivery devices for viscous parenteral solutions beyond that level are numerous and multifaceted. 54 The existing arsenal ranges from using tapered needles, i.e., they have a larger diameter at their proximal end than at their distal end, to needles with ultra-thin walls while maintaining the same outer diameter, 55,56 to high pressure injectors with various pressure profiles, which are available in various types. Some are designed to inject solutions with viscosity values up to 1000 cP through 25 G needles such as the Bespak and Arc-Bios systems.…”

Section: What If Formulation Approaches Fail To Provide a "Solution"?mentioning

confidence: 99%

Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis?

Jiskoot

Hawe²,

Menzen³

et al. 2022

Journal of Pharmaceutical Sciences

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User experience for manual injection of 2 mL viscous solutions is enhanced by a new prefillable syringe with a staked 8 mm ultra-thin wall needle

Abstract: Glezer (2020) User experience for manual injection of 2 mL viscous solutions is enhanced by a new prefillable syringe with a staked 8 mm ultra-thin wall needle,

Cited by 5 publications

References 46 publications

Microfluidic Delivery of High Viscosity Liquids Using Piezoelectric Micropumps for Subcutaneous Drug Infusion Applications

Microfluidic Delivery of High Viscosity Liquids Using Piezoelectric Micropumps for Subcutaneous Drug Infusion Applications

Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume

Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis?

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