As an essential part of China’s revolutionary history and culture in the current Internet era, applying the symbols of Sichuan and Chongqing red culture in creating Chinese paintings has received increasing attention. The creation of modern Chinese paintings is inspired by the rich historical and cultural values carried by this cultural symbol. By studying the use of Sichuan and Chongqing red cultural symbols in Chinese painting, we can deepen our understanding of the communicative efficacy of the cultural symbols, and provide theoretical support and practical guidance to promote the innovative development of Chinese painting. This study thoroughly analyzes the connotations of the red cultural symbols in Sichuan and Chongqing and their application in creating Chinese paintings. In this paper, the Sichuan and Chongqing red cultural symbols enhance Chinese paintings’ cultural connotation and expressive power. Through the Analysis of 2,000 works, the average audience evaluation score of the works using the Sichuan and Chongqing red cultural symbols is 20% higher than those that do not use them. The effective integration of Sichuan and Chongqing red cultural symbols in this study enriches the expression of Chinese painting, promotes the integration of traditional and modern culture, and provides a new path for the innovative development of Chinese painting.