2021
DOI: 10.3389/fitd.2021.711425
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Using a One Health Case-Based Investigation for Improved Control of Brucellosis in Isiolo, Kenya

Abstract: Brucella is a highly pathogenic bacteria endemic in Kenya, and in spite of its severity in humans, the highly inadequate Febrile Antigen Brucella Agglutination Test (FBAT) remains a primary tool for its diagnosis. Blood samples were collected from febrile patients in Kinna health center and screened by the local routine. Milk samples were purchased from local milk hawkers and analyzed for Brucella antibodies using the milk ring test (MRT). The MRT-positive milk was traced to farms, and lactating cattle were sa… Show more

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Cited by 2 publications
(1 citation statement)
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“…Brucellosis is an important zoonotic disease that affects domestic livestock and wildlife, the second most transmissible zoonotic disease worldwide next to rabies, a serious health hazard but its public health concern has been neglected in many countries, a notifiable disease, and considered a bio-threatening (category B) agent [ 1 ]. This zoonotic infection is caused by Brucella , four species are known to infect humans among which majority of the cases are caused by B. abortus and B. melitensis [ 2 ]. Brucella has been reported to possess five virulence factors necessary for infection and survival within the host including cyclic β-glucan, virB T4SS, pathogen-associated molecular patterns (PAMPs), two component sensory and regulatory system BvrS/BvrR and lipopolysaccharide (LPBS); as well as it requires four steps to successfully establish an infection to its host such as adherence, invasion, establishment and dissemination [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…Brucellosis is an important zoonotic disease that affects domestic livestock and wildlife, the second most transmissible zoonotic disease worldwide next to rabies, a serious health hazard but its public health concern has been neglected in many countries, a notifiable disease, and considered a bio-threatening (category B) agent [ 1 ]. This zoonotic infection is caused by Brucella , four species are known to infect humans among which majority of the cases are caused by B. abortus and B. melitensis [ 2 ]. Brucella has been reported to possess five virulence factors necessary for infection and survival within the host including cyclic β-glucan, virB T4SS, pathogen-associated molecular patterns (PAMPs), two component sensory and regulatory system BvrS/BvrR and lipopolysaccharide (LPBS); as well as it requires four steps to successfully establish an infection to its host such as adherence, invasion, establishment and dissemination [ 3 ].…”
Section: Introductionmentioning
confidence: 99%