In order to accurately analyze and evaluate multi-index and multi-route traffic schemes for comparison and selection, we introduce herein a comprehensive weight and an intelligent selection algorithm for traffic scheme optimization to improve upon the shortcomings of common qualitative and quantitative analysis methods. Firstly, we establish an evaluation index system of transportation by traffic scheme considering the factors of technology, ecological environment, social environment, and economy, based on the whole life cycle. Secondly, the comprehensive weight based on subjective and objective factors is constructed. Finally, we establish an optimization method for transportation schemes by using the comprehensive weight and Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) model. The results show that the evaluation index system based on the whole life cycle is more comprehensive and accurate. The comprehensive weight vector avoids the defects of single weight methods and makes full use of subjective data and expert opinions. The comprehensive weight vector is introduced into the decision-maker’s preference coefficient, so that analysts can determine the scheme according to the subjective and objective information and to the required accuracy. This method uses a large number of evaluation groups to evaluate the scheme, and the evaluation results show greater objectivity and efficiency.