Using chiral magnetic surface molecularly imprinted polymers for chiral separation of Ofloxacin

Zhao, Chen; Lu, Wen‐Zhong; Meng, Xiangyan

doi:10.1007/s10965-021-02581-3

Cited by 8 publications

(10 citation statements)

References 21 publications

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“…32 A chiral magnetic MIP containing Fe 3 O 4 functionalized with N-octyl-D-glucosamine was utilized to differentiate the enantiomeric forms of ofloxacin. 33 Furthermore, it has been shown that chitosan-derived MIP may be used to distinguish between the chiral forms of ketoprofen 34 and to detect and distribute S-sulpiride. 35 Norepinephrine (NEP) is a common catecholamine with a number of physiological effects, including increased blood pressure, vasoconstriction, and amplification of nerve impulse transmission.…”

Section: Introductionmentioning

confidence: 99%

“…Theoretical and experimental researches were used to assess the improved imprinting and enantio‐selectivity 32 . A chiral magnetic MIP containing Fe 3 O 4 functionalized with N‐octyl‐D‐glucosamine was utilized to differentiate the enantiomeric forms of ofloxacin 33 . Furthermore, it has been shown that chitosan‐derived MIP may be used to distinguish between the chiral forms of ketoprofen 34 and to detect and distribute S‐sulpiride 35 …”

Section: Introductionmentioning

confidence: 99%

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Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

Abomuti

2024

Chirality

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We are looking into how well a copolymeric material made of poly (maleic acid–co‐4‐vinylpyridine) cross‐linked with divinylbenzene can separate L‐norepinephrine (L‐NEP) from (±)‐NEP. The initial step in this direction was the synthesis and subsequent analysis of L‐NEP‐maleimide chiral derivative. A 4‐vinylpyridine/divinylbenzene combination was copolymerized with the resultant chiral maleimide. After heating the polymer materials in a high‐alkaline environment to breakdown the connecting imide bonds, they were acidified in an HCl solution to eliminate the incorporated L‐NEP species. Fourier transform infrared spectroscopy (FTIR) and a scanning electron microscope were used to examine the imprinted L‐NEP‐imprinted materials. The manufactured L‐NEP‐imprinted materials exhibited selectivity characteristics that were over 11 times greater for L‐NEP than D‐norepinephrine. The highest capacity observed in Langmuir adsorption studies was 170 mg/g at a pH of 7. After optical separation using a column technique, it was determined that the enantiomeric excess levels of D‐norepinephrine and L‐NEP in the first feeding and subsequent recovery solutions were 95% and 81%, respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

Abomuti

2024

Chirality

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“…Nowadays, MIP-NMs have been widely used in various fields of drug research, such as the separation and purification of target substances, the extraction of active ingredients from a drug [ 32 ], and their application to drug delivery systems to achieve controlled or sustained drug release. Therefore, many drug molecules are introduced as template molecules, such as paracetamol, ofloxacin, the antidepressant sertraline, and carbamazepine [ 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Nanomaterials with Stimuli Responsiveness for Applications in Biomedicine

et al. 2023

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The review aims to summarize recent reports of stimuli-responsive nanomaterials based on molecularly imprinted polymers (MIPs) and discuss their applications in biomedicine. In the past few decades, MIPs have been proven to show widespread applications as new molecular recognition materials. The development of stimuli-responsive nanomaterials has successfully endowed MIPs with not only affinity properties comparable to those of natural antibodies but also the ability to respond to external stimuli (stimuli-responsive MIPs). In this review, we will discuss the synthesis of MIPs, the classification of stimuli-responsive MIP nanomaterials (MIP-NMs), their dynamic mechanisms, and their applications in biomedicine, including bioanalysis and diagnosis, biological imaging, drug delivery, disease intervention, and others. This review mainly focuses on studies of smart MIP-NMs with biomedical perspectives after 2015. We believe that this review will be helpful for the further exploration of stimuli-responsive MIP-NMs and contribute to expanding their practical applications especially in biomedicine in the near future.

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“…[32][33][34][35][36][37][38] Ofloxacin in oral dosages is typically 75 %-80 % unaltered upon excretion in the urine. [38][39][40][41] The main goal of this research was to create and study a new class of stereoselective S-OFX molecularly imprinted silica adsorbent (S-OFX-Sil) with -NH 2 functional groups. Carbodiimide was used to initiate the reaction between the S-OFX enantiomer and 3-aminopropyltriethoxysilane (Si-NH 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…S‐OFX is 8‐ to 128‐fold more effective than R‐OFX against gram‐positive and gram‐negative bacteria, respectively [32–38] . Ofloxacin in oral dosages is typically 75 %–80 % unaltered upon excretion in the urine [38–41] …”

Section: Introductionmentioning

confidence: 99%

Construction of Amino‐Functionalized Molecularly Imprinted Silica Particles for (±)‐Ofloxacin Chiral Separation

Alatawi

2023

ChemistrySelect

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To enantioselectively separate a (�)-ofloxacin (OFX) racemic mixture, we describe the production and successful use of an S-ofloxacin (S-OFX) enantio-selective sorbent with amino functional groups. An amide derivative was first synthesized by reacting the S-OFX enantiomer with 3-aminopropyltriethoxysilane (S-OFX-Si-NH 2 ). The generated S-OFX-Si-NH 2 derivative was then mixed with tetraethoxysilane (TEOS) and put through a base-catalyzed sol-gel condensation polymerization process to insert the S-OFX enantiomeric species into the crosslinked material. To facilitate recombination involving S-OFX, an enantioselective gap is created by alkaline hydrolysis followed by acidification, freeing the S-OFX from the crosslinked matrix and filling the resulting gaps with cationic ions compatible with the S-OFX. Our chemical transformations of the monomeric precursor and the ensuing S-OFX molecularly imprinted material (S-OFX-Sil) were confirmed by elemental analysis, nuclear magnetic resonance (NMR), and Fourier transform infrared spectroscopy (FTIR). In addition, scanning electron microscopy images of the sorbent surface were employed to comprehend the morphological adjustments. Both the first loading run (60 % ee of R-OFX) and the second elution run (83 % ee of S-OFX) using the manufactured adsorbent particles showed promising separation results.

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Using chiral magnetic surface molecularly imprinted polymers for chiral separation of Ofloxacin

Cited by 8 publications

References 21 publications

Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

Chiral acidic molecularly imprinted polymer for enantio‐separation of norepinephrine racemate

Molecularly Imprinted Nanomaterials with Stimuli Responsiveness for Applications in Biomedicine

Construction of Amino‐Functionalized Molecularly Imprinted Silica Particles for (±)‐Ofloxacin Chiral Separation

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