Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

Noorafshan, Ali; Karimi, Fatemeh; Karbalay‐Doust, Saied; Kamali, Ali Mohammad

doi:10.17179/excli2017-139

Cited by 18 publications

(19 citation statements)

References 28 publications

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“…The protective effect of curcumin in the prefrontal cortex has also been demonstrated in animal models. Noorafshan et al used three different neural damage rat models, including stress-induced, sulfite-induced, and sleep deprivation, and found that curcumin could prevent structural deterioration in neurons and glial cells, and could also counteract behavioral changes [8,56,57]. This showed that curcumin had a direct protective effect on the prefrontal cortex and may explain why curcumin was able to effectively improve working memory, as observed in our meta-analysis.…”

Section: Effects Of Curcumin On Different Cognitive Domainssupporting

confidence: 71%

“…Animal studies have also confirmed that curcumin has protective effects against cognitive decline, both in aging rhesus monkeys [6] and in a streptozotocin-induced dementia rat model [7]. Specifically, curcumin has been found to exhibit various selective effects, including preventing atrophic change and cell loss in the prefrontal cortex compared to the hippocampus [7,8], decreasing neuroinflammation compared to promoting neurogenesis [7], and more positive effects on working memory than on recognition [6].…”

Section: Introduction 1curcumin In Cognitive Decline Animal Studiesmentioning

confidence: 88%

“…However, in Alzheimer's disease, curcumin seems to have a detrimental effect compared with placebo (standardized mean difference = −0.9, p = 0.002). Since Alzheimer's disease tends to involve the prefrontal cortex [8] and cause corresponding working memory deficits [17], these differences in outcomes across healthy and diseased populations may indicate the selective effects of curcumin on different brain regions and cognitive domains.…”

Section: Curcumin In Cognitive Epidemiological Studies and Clinical T...mentioning

confidence: 99%

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The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis

et al. 2021

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Curcumin is a polyphenol with strong antioxidant and anti-inflammatory effects that has been shown to be effective in ameliorating cognitive decline in animal studies. However, its clinical effectiveness is inconclusive, and relevant gastrointestinal adverse events (AEs) have been reported. The aim of this meta-analysis was to summarize the existing evidence from randomized controlled trials (RCTs) of effects of curcumin on overall cognitive function, individual cognitive domains, and gastrointestinal AE. The study includes 8 RCTs and 389 participants. A random-effects model was used for the meta-analysis. Compared with the placebo group, the curcumin group was associated with an improvement in working memory (Hedges’ g = 0.396, 95% confidence interval (CI) = 0.078 to 0.714, p = 0.015) and a borderline benefit in processing speed (Hedges’ g = 0.303, 95% CI = −0.013 to 0.619, p = 0.06). In the domains of language, episodic memory/visual learning, verbal memory, cognitive flexibility/problem solving, and overall cognitive function, no significant difference existed for the comparison between the curcumin and placebo groups. The curcumin group had a significantly higher risk of gastrointestinal AEs than the placebo group (odds ratio = 3.019, 95% CI = 1.118 to 8.150, p = 0.029). In the future, the effects of curcumin on working memory, processing speed, and gastrointestinal AE should be further investigated.

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Section: Effects Of Curcumin On Different Cognitive Domainssupporting

confidence: 71%

Section: Introduction 1curcumin In Cognitive Decline Animal Studiesmentioning

confidence: 88%

Section: Curcumin In Cognitive Epidemiological Studies and Clinical T...mentioning

confidence: 99%

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The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis

et al. 2021

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“…Noorafshan et al conducted a research to analyze the potential effects of curcumin treatment on rapid eye movement sleep deprival (REM-SD) [ 16 ]. It was determined that the volume, cell number, reconstruction, object recognition time, and body weight were recovered in the REM − SD + curcumin group compared to the REM − SD + distilled water group.…”

Section: Role Of Curcumin In Sleep Disorders and Alzheimer's Disease:...mentioning

confidence: 99%

“…Unfortunately, problems of SD are increasing in public nowadays [ 15 ]. The effects of curcumin on the medial prefrontal cortex (mPFC) [ 16 ], the protective potential on the dendritic trees from shortening and shedding induced by chronic SD [ 14 ], and the effects of SD-induced memory impairments have been demonstrated by in vivo studies [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

A New Perspective on the Treatment of Alzheimer’s Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?

Akkol

Bardakçı

Yücel

et al. 2022

Oxidative Medicine and Cellular Longevity

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Sleep disturbances, as well as sleep-wake rhythm disorders, are characteristic symptoms of Alzheimer’s disease (AD) that may head the other clinical signs of this neurodegenerative disease. Age-related structural and physiological changes in the brain lead to changes in sleep patterns. Conditions such as AD affect the cerebral cortex, basal forebrain, locus coeruleus, and the hypothalamus, thus changing the sleep-wake cycle. Sleep disorders likewise adversely affect the course of the disease. Since the sleep quality is important for the proper functioning of the memory, impaired sleep is associated with problems in the related areas of the brain that play a key role in learning and memory functions. In addition to synthetic drugs, utilization of medicinal plants has become popular in the treatment of neurological diseases. Curcuminoids, which are in a diarylheptanoid structure, are the main components of turmeric. Amongst them, curcumin has multiple applications in treatment regimens of various diseases such as cardiovascular diseases, obesity, cancer, inflammatory diseases, and aging. Besides, curcumin has been reported to be effective in different types of neurodegenerative diseases. Scientific studies exclusively showed that curcumin leads significant improvements in the pathological process of AD. Yet, its low solubility hence low bioavailability is the main therapeutic limitation of curcumin. Although previous studies have focused different types of advanced nanoformulations of curcumin, new approaches are needed to solve the solubility problem. This review summarizes the available scientific data, as reported by the most recent studies describing the utilization of curcumin in the treatment of AD and sleep deprivation-related consequences.

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Post‐weaning exposure to Sunset Yellow FCF induces behavioral impairment and structural changes in the adult rat medial prefrontal cortex: Protective effects of Coenzyme Q10

Karimi

Anari

Nejad

et al. 2022

Intl J of Devlp Neuroscience

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Sunset Yellow FCF (E110) is a water‐soluble synthetic dye that has adverse neurobehavioral effects. Coenzyme Q10 (CoQ10) is known as a neuroprotective agent. The present study aimed to evaluate the effects of post‐weaning exposure to Sunset Yellow FCF on behavioral and structural changes in the adult rat medial prefrontal cortex (mPFC) and the protective effects of CoQ10. The weanling rats were randomly divided into six groups: distilled water, CoQ10 (10 mg/kg/day), and low (2.5 mg/kg/day) and high (70 mg/kg/day) doses of Sunset Yellow FCF with or without CoQ10 consumption for 6 weeks. A battery of behavioral tests including open field and Morris water maze tests were done at the end of the sixth week, and then the animals' brains were removed for stereological methods. Our finding indicated that the high dose of Sunset Yellow FCF led to a reduced total volume of mPFC (15.16%), especially in the anterior cingulate cortex (ACC) region (21.96%), along with loss of neurons (32%) and glial cells (37%), which was associated with higher anxiety behavior and loss of spatial memory. However, CoQ10 prevented the neural loss and glial cells, improved anxiety‐like behaviors, and memory impairment. On the other hand, the acceptable daily dose (low dose of Sunset Yellow FCF) did not show a discernible effect on the same parameters. This study showed that the CoQ10 can protect the alteration in mPFC structure and behavioral changes of the rats exposed to high dose of Sunset Yellow FCF.

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Using curcumin to prevent structural and behavioral changes of medial prefrontal cortex induced by sleep deprivation in rats

Cited by 18 publications

References 28 publications

The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis

The Effect of Curcumin Differs on Individual Cognitive Domains across Different Patient Populations: A Systematic Review and Meta-Analysis

A New Perspective on the Treatment of Alzheimer’s Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?

Post‐weaning exposure to Sunset Yellow FCF induces behavioral impairment and structural changes in the adult rat medial prefrontal cortex: Protective effects of Coenzyme Q10

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