Using Cytotoxic Drugs Safely

A Controlled and Selective Bromination of Phenols by Benzyltriphenylphosphonium Tribromide

“…9 This reagent showed an intense ultraviolet absorption at 267 nm typical of tribromide (Br 3 -) group. 10 Reagent 3 was reacted with several phenol derivatives 4a-o in presence of CaCO 3 in dichloromethane-methanol solution (2:1) at room temperature. The bromination reactions occurred under mild conditions and gave mono, di and tribrominated compounds in good yields, Scheme 3, Table 1.…”