Using Functional Neuroimaging to Refine the Diagnostic Construct of Borderline Personality Disorder

Silverman, Merav H.; Schulz, S. Charles; Cullen, Kathryn R.

doi:10.17756/jnpn.2016-005

Cited by 3 publications

(2 citation statements)

References 188 publications

(229 reference statements)

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“…Most regions where differences were found in the brain function in BPD form part of the frontolimbic circuit. Dysfunction of frontolimbic circuitry is one of the most accepted models to explain the BPD symptoms, including emotional dysregulation and social cognition deficits (26). This same circuit has been related to morphologic and functional brain changes associated with a history of child abuse (27).…”

Section: Introductionmentioning

confidence: 99%

Effects of Childhood Maltreatment on Social Cognition and Brain Functional Connectivity in Borderline Personality Disorder Patients

et al. 2019

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Borderline personality disorder (BPD) is a chronic condition characterized by high levels of impulsivity, affective instability, and difficulty to establish and manage interpersonal relationships. However, little is known about its etiology and neurobiological substrates. In our study, we wanted to investigate the influence of child abuse in the psychopathology of BPD by means of social cognitive paradigms [the Movie for the Assessment of Social Cognition (MASC) and the reading the mind in the eyes test (RMET)], and resting state functional magnetic resonance imaging (rs-fMRI). For this, we recruited 33 participants, 18 BPD patients, and 15 controls. High levels of self-reported childhood maltreatment were reported by BPD patients. For the sexual abuse subdimension, there were no differences between the BPD and the control groups, but there was a negative correlation between MASC scores and total childhood maltreatment levels, as well as between physical abuse, physical negligence, and MASC. Both groups showed that the higher the level of childhood maltreatment, the lower the performance on the MASC social cognitive test. Further, in the BPD group, there was hypoconnectivity between the structures responsible for emotion regulation and social cognitive responses that have been described as part of the frontolimbic circuitry (i.e., amygdala). Differential levels of connectivity, associated with different types and levels of abuse were also observed.

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Section: Introductionmentioning

confidence: 99%

Effects of Childhood Maltreatment on Social Cognition and Brain Functional Connectivity in Borderline Personality Disorder Patients

et al. 2019

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“…65 A major confounding influence across studies of BPD is heterogeneity in symptom presentation (i.e., 256 possible symptom combinations). 70 Multiple other factors may also be contributory. A recent systematic review of the evidence for altered interpersonal functioning in BPD (i.e., social cognition, reactivity to interpersonal stressors, interpersonal aggression, differences in trust and cooperation) emphasized the importance of utilizing objective assessments of behavior rather than relying on self-report measures.…”

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confidence: 99%

Borderline Personality Disorder: Neurobiological Contributions to Remission and Recovery

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Hurley

Taber

2017

JNP

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FIGURE 1. Longitudinal studies indicate that the majority of individualswith Borderline Personality Disorder (BPD) eventually experience symptom remission. 1,2 A much smaller proportion achieve recovery (no longer meeting diagnostic criteria for the disorder and improvements on functional measures indicating a generally good outcome). The results of two studies that performed longitudinal assessments on individuals with BPD are illustrated. One study required that remission be sustained for one year (purple). 1 The other study required that it be sustained for two years (orange). 2 Similarly, one study required that recovery be sustained for one year (blue), the other required that it be sustained for two years (yellow).

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Effects of childhood maltreatment on social cognition and brain functional connectivity in borderline personality disorder patients

Duque

Alcalá-Lozano

González-Olvera

et al. 2018

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32Borderline personality disorder (BPD) is a chronic condition characterized by high levels of 33 impulsivity, affective instability, and difficulty to establish and manage interpersonal relationships. 34This paper assessed differences in performance on social cognitive paradigms (MASC, RMTE) and 35 how it related to child abuse. Specifically, it evaluated the relationship between performance on 36 cognitive paradigms and baseline brain connectivity in patients with BPD, compared to healthy 37 controls. 38BPD patients had higher levels of childhood maltreatment, increased impulsivity and aggression, and 39 more dissociative symptoms than control subjects. For the sexual abuse subdimension, there were no 40 differences between the BPD and the control groups, but there was a negative correlation between 41 MASC scores and total childhood maltreatment levels, as well as between physical abuse, physical 42 negligence, and MASC. Both groups showed that the higher the level of childhood maltreatment, the 43 lower the performance on the MASC social cognitive test. Further, in the BPD group, there was 44 hypoconnectivity between the structures responsible for emotion regulation and social cognitive 45 responses that have been described as part of the frontolimbic circuitry. The more serious the child 46 abuse, the lower the connectivity. 47 48

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Using Functional Neuroimaging to Refine the Diagnostic Construct of Borderline Personality Disorder

Cited by 3 publications

References 188 publications

Effects of Childhood Maltreatment on Social Cognition and Brain Functional Connectivity in Borderline Personality Disorder Patients

Effects of Childhood Maltreatment on Social Cognition and Brain Functional Connectivity in Borderline Personality Disorder Patients

Borderline Personality Disorder: Neurobiological Contributions to Remission and Recovery

Effects of childhood maltreatment on social cognition and brain functional connectivity in borderline personality disorder patients

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