Using human umbilical cord mesenchymal stem cells combined with allogenic platelet-rich fibrin membrane for the treatment of dual limb ischemia in an elderly patient

Abstract

Rationale: To describe the clinical effects of human umbilical cord mesenchymal stem cells (UCMSCs) combined with allogenic platelet-rich fibrin (PRF) for the treatment of lower limb ischemia in an elderly patient. Patient concerns: The patient was a 93-year-old Chinese woman with bilateral foot gangrene and ulcers lasting for 6 months. She had a prior history of Behcet's disease. Diagnoses: The admitting diagnosis for this episode was atherosclerosis bilateral limb ischemia. Interventions: First, treatment consisting of immunosuppressants, anticoagulation, antiplatelets, and anti-microbials were instituted. A UCMSC suspension was administered intravenously and injected into the lower limbs twice. An allogenic PRF membrane was externally applied 15 times over the lower limbs. Outcomes: The patient's pain improved and the 6 ulcers healed. Lessons: The combination of UCMSCs with a PRF membrane for the treatment of lower limb ischemia in an elderly patient is effective and safe. More and larger trials are needed before incorporating this therapy into mainstream treatment.

The role of allogeneic platelet-rich plasma in patients with diabetic foot ulcer: Current perspectives and future challenges

“…In 2010, Scevola et al (2010) recruited 13 patients who suffered pressure sores because of prolonged bed rest secondary to spinal injuries. Even though there was no significant difference in the final reduced ulcer area, al-PRP gel was more effective in accelerating ulcer healing in the In recent case reports, al-PRP was proven to be safe and efficacious for chronic wounds either as an application of al-PRP alone (Oliveira et al, 2017;Zhao et al, 2019) or in combination as an adjuvant method (Hernandez et al, 2012;Ju et al, 2021). Furthermore, a prospective, randomized, single-center study was conducted recently and enrolled 60 patients with chronic wounds.…”

“…In recent case reports, al-PRP was proven to be safe and efficacious for chronic wounds either as an application of al-PRP alone ( Oliveira et al, 2017 ; Zhao et al, 2019 ) or in combination as an adjuvant method ( Hernandez et al, 2012 ; Ju et al, 2021 ). Furthermore, a prospective, randomized, single-center study was conducted recently and enrolled 60 patients with chronic wounds.…”