Using Lactobacillus as Probiotic to Inhibit Growth and Adhesion of Proteus mirabilis Causing Urinary Tract Infection

Abstract

The aim of the study was to use lactic acid bacteria (LAB), as probiotic, to treat growth and adhesion property of Proteus mirabilis isolated from patients suffering from urinary tract infection (UTI). For this purpose, one P. mirabilis isolate (P.M.9) was selected out of 9 isolates obtained from 150 urine specimens. Due to its resistance to 11 antibiotics tested, this isolate was treated with three-fold concentrated filtrates of two lactobacillus isolates (as probiotic). Results after treatment, showed that the filtrates exhibited significant inhibitory effect against the pathogenic P.M.9 and its adhesion property especially when only an average of 3-10 bacteria /cell were adhered to each epithelial cell compared to 44-55 bacteria/cell.

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“…Some investigators stated a high inhibitory effects of LAB against the enteropathogenic bacteria (6). While others documented a significant inhibition of LAB on Proteus mirabilis , proposing the effect to the presence of active antimicrobial secretions such as lactocidin , plantaracin and acidophilin, these results agreed with the results obtained in this work (9). The obtained data reflect a remarkable decrease in the numbers of all tested adhered bacterial cells to the epithelium cells, these results come in comformity with results onbtaned by some investigators .…”