Using LC/MS/MS to determine matrine, oxymatrine, ferulic acid, mangiferin, and glycyrrhizin in the Chinese medicinal preparations Shiau-feng-saan and Dang-guei-nian-tong-tang

Jong, Ting‐Ting; Lee, Maw-Rong; Chiang, Yi-Cheng; Chiang, Shu-Tuan

doi:10.1016/j.jpba.2005.07.036

Cited by 49 publications

(23 citation statements)

References 8 publications

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“…The daughter ion at m/z 178 was formed by the loss of one water molecule from the parent ion. Based on the MS and UV information and comparing with the literature data (Jong et al 2006), compound 1 was identified as ferulic acid.…”

Section: Hplc-esi-ms/ms Analysismentioning

confidence: 99%

Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L.

et al. 2014

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Asparagus residues were used as materials to obtain antioxidant compounds by solid-liquid extraction in this study. The effects of different extraction parameters including extraction solvents, time, temperature and liquid-solid ratio on the contents of total flavonoids, total phenolics and total antioxidant activity were investigated. Antioxidant activity of the extract from asparagus residues was evaluated by HPLC-ABTS· + and the bioactive components were identified by HPLC-MS/MS. The results showed that the extraction yield was significantly influenced (P<0.05) by solvent composition, extraction time and temperature. The appropriate parameters were preferred as extraction solvent of 50 % ethanol with liquid-solid ratio of 30:1, extraction temperature of 80°C and time of 2 h. Antioxidant activity evaluation of the extract indicated flavonoids and phenolics were dominant bioactive compounds. Five antioxidant compounds were identified as ferulic acid, kaempferol, quercetin, rutin and isorhamnetin.

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Section: Hplc-esi-ms/ms Analysismentioning

confidence: 99%

Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L.

et al. 2014

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“…OMT has been used in the treatment of skin diseases (such as eczema, alopecia, and psoriasis), the effect on acute lung injury by the capillary electrophoresis (CE) and the liquid chromatography tandem mass spectrometry method (Xu et al, 2005;Ku et al, 2002;Zhang et al, 2008a, b;Wang et al, 2005Wang et al, , 2007Cheng et al, 2004;Jong et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Study on the interaction of oxymatrine with bovine serum albumin

Zhu

Sun

et al. 2010

Med Chem Res

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The binding reaction of oxymatrine (OMT) with bovine serum albumin (BSA) was studied by the methods of isothermal titration calorimetry, fluorescence, and circular dichroism (CD) spectroscopy. The thermodynamic results indicated that there were two classes of binding sites on the BSA molecule for OMT molecule. When the drug molecule binding to the first class of sites, the standard changes of enthalpy (DH 1°) and entropy (DS 1°) were (-1.07 ± 0.50) kJ/mol and (98.3 ± 0.50) J/ mol/K, respectively. The possible largest number of binding site (N 1 ) was (10.0 ± 0.20). This type of binding was an enthalpy-entropy synergically driven process. On the second class of binding sites, the standard changes of enthalpy (DH 2°) and entropy (DS 2°) were (1.91 ± 0.03) kJ/ mol and (79.8 ± 0.40) J/mol/K, respectively. The possible largest number of binding site (N 2 ) was (25.0 ± 0.30). This type of binding was entropy driven process. The intrinsic fluorescence of BSA was slightly quenched by the formation of BSA-OMT complex. The CD spectra experiment showed that the a-helix contents of BSA decreased. These revealed that the microenvironment and conformation of BSA were changed in the binding reaction.

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“…[7][8][9] Several methods such as thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and mass spectrometry (MS) have been developed to analyze matrine. 10,11 However, electroanalytical method requires less pretreatment steps. It offers high resolution, rapid analysis, and lower running cost.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Behaviors of Matrine at L-Cysteine-Modified Electrodes

Miao

Chen

2008

Surf. Rev. Lett.

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Matrine is an important natural occurring component in sophora roots. It has a wide range of pharmacological actions. In this work, electrochemical investigation of matrine and its interaction with L-cysteine (L-Cys) is reported. Via the electrochemical approach, we have proved that the distribution coefficients of protonated and deprotonated matrine affect its electrochemical response on Au or L-Cys modified Au electrodes. The study by ultraviolet spectroscopy also finds that the molecular interaction between matrine and L-Cys changes with the distribution coefficients of protonated and deprotonated matrine at different pH value. Compared with the response of matrine on the bare gold electrode, the L-Cys/Au self-assembled monolayers modified electrodes exhibit obviously higher current response toward matrine oxidation. The oxidation current of matrine at L-Cys assembled electrode has a good linear relation in the range of 0.2-5 mM, with the correlation coefficient of 0.989 by cyclic voltammagrams. Electrochemical combined with spectroscopic techniques would provide relatively easy way to better understand the underlying mechanism of matrine/L-Cys interaction and will be helpful for the development of electroanalytical techniques for the determination of matrine.

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Using LC/MS/MS to determine matrine, oxymatrine, ferulic acid, mangiferin, and glycyrrhizin in the Chinese medicinal preparations Shiau-feng-saan and Dang-guei-nian-tong-tang

Cited by 49 publications

References 8 publications

Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L.

Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L.

Study on the interaction of oxymatrine with bovine serum albumin

Electrochemical Behaviors of Matrine at L-Cysteine-Modified Electrodes

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