Using magnetic nanoparticles/MIP-based electrochemical sensor for quantification of tetracycline in milk samples

Zeb, Shakeel; Wong, Ademar; Khan, Sabir; Hussain, Sajjad; Sotomayor, Marı́a Del Pilar Taboada

doi:10.1016/j.jelechem.2021.115713

Cited by 51 publications

(30 citation statements)

References 32 publications

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“…For example, a chitosan-gold nanocomposite was employed as supporting material for the preparation of a MIP which was further drop-cast on a GCE to obtain a sensor for CIP determination [16]. There are also interesting approaches that use magnetic materials such as Fe 3 O 4 with and without other NPs in order to amplify the sensor electrochemical response [32,103]. Due to their cost-effectiveness, high chemical stability and good sensitivity, magnetic nanoparticles covered with MIPs were incorporated into CPEs developed for the detection of AMOX [6] and TC [32] at µM levels in water and milk samples, respectively.…”

Section: Modification Of the Original Carbon-based Electrodementioning

confidence: 99%

“…The adequate amounts of monomer (AAM) and cross-linker (MBAA) were also assessed using the response surface methodology [12]. Usually, the process takes place in an inert atmosphere of N 2 and lasts a long time (e.g., 3 h [6], 12 h [23] or even 24 h [32,97,101]). For example, the pre-polymer mixture for the synthesis of a CAP-imprinted polymer was obtained by dissolving the template in MAA, the addition of EGDMA, THF and finally AIBN.…”

Section: Polymerization Proceduresmentioning

confidence: 99%

“…The functional monomer represents the basis for the future 3D structure of the MIP. When selecting the monomer and the monomer: template ratio it is important to elucidate the interaction mechanism between the functional groups of the monomer and of the analyte and this can be performed by UV-Vis spectrometric investigations [114] or by computer simulation [18,23,32,39,99]. A monomer frequently employed in the generation of MIPs for antibiotic sensing was pyrrole [7,22,31,93,99], due to the fact that PPy can be easily obtained, it is stable, biocompatible and possesses good conductivity and redox properties [72].…”

Section: Polymerization Reagentsmentioning

confidence: 99%

“…The widespread and continuously growing use of antibiotics has led to the contamination of various matrices such as human body fluids, food products (e.g., meat and derivatives, eggs, dairy products), beverages (e.g., milk, drinking water) and environmental resources (e.g., surface and ground waters, soil, sediments) with these parent drugs as well as with their metabolites. Antibiotic residues can exist in the food chain and can accumulate in foodstuffs [30], mainly as a result of their administration to food-producing animals [31], but also due to their addition to dairy products as chemical preservatives (e.g., tetracycline) [32]. Antibiotics can enter the environment directly from the pharmaceutical producers (including research laboratories and industrial production) as contaminated wastewaters or after their use in human or veterinary medicine (excreted through urine and feces or discarded as domestic or hospital waste) [6] or from agricultural activities (e.g., runoff from agricultural land and from animal farms, soils enriched with manure) [5,15,25], including aquaculture [26].…”

Section: Introductionmentioning

confidence: 99%

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Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

et al. 2022

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Antibiotics are antibacterial agents applied in human and veterinary medicine. They are also employed to stimulate the growth of food-producing animals. Despite their benefits, the uncontrolled use of antibiotics results in serious problems, and therefore their concentration levels in different foods as well as in environmental samples were regulated. As a consequence, there is an increasing demand for the development of sensitive and selective analytical tools for antibiotic reliable and rapid detection. These requirements are accomplished by the combination of simple, cost-effective and affordable electroanalytical methods with molecularly imprinted polymers (MIPs) with high recognition specificity, based on their “lock and key” working principle, used to modify the electrode surface, which is the “heart” of any electrochemical device. This review presents a comprehensive overview of MIP-modified carbon-based electrodes developed in recent years for antibiotic detection. The MIP preparation and electrode modification procedures, along with the performance characteristics of sensors and analytical methods, as well as the applications for the antibiotics’ quantification from different matrices (pharmaceutical, biological, food and environmental samples), are discussed. The information provided by this review can inspire researchers to go deeper into the field of MIP-modified sensors and to develop efficient means for reliable antibiotic determination.

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Section: Modification Of the Original Carbon-based Electrodementioning

confidence: 99%

Section: Polymerization Proceduresmentioning

confidence: 99%

Section: Polymerization Reagentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

et al. 2022

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“…Molecularly imprinted technology provides selective sensors since they are built with specific recognition sites for the molecule that we want to analyze. MIPs for pharmaceuticals have been designed and have proved to be an excellent choice for the construction of highly selective sensors [ 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Electropolymerized, Molecularly Imprinted Polymer on a Screen-Printed Electrode—A Simple, Fast, and Disposable Voltammetric Sensor for Trazodone

Seguro

Rebelo

Pacheco

et al. 2022

Sensors

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In recent years, analytical chemistry has been facing new challenges, particularly in developing low-cost, green, and easy-to-reproduce methods. In this work, a simple, reproducible, and low-cost electrochemical (voltammetric) molecularly imprinted polymer (MIP) sensor was designed specifically for the detection of trazodone (TZD). Trazodone (TZD) is an antidepressant drug consumed worldwide since the 1970s. By combining electropolymerization (surface imprinting) with screen-printed electrodes (SPCEs), the sensor is easy to prepare, is environmentally friendly (uses small amounts of reagents), and can be used for in situ analysis through integration with small, portable devices. The MIP was obtained using cyclic voltammetry (CV), using 4-aminobenzoic acid (4-ABA) as the functional monomer in the presence of TZF molecules in 0.1 M HCl. Non-imprinted control was also constructed in the absence of TZD. Both polymers were characterized using CV, and TZD detection was performed with DPV using the oxidation of TZD. The polymerization conditions were studied and optimized. Comparing the TZD signal for MIP/SPCE and NIP/SPCE, an imprinting factor of 71 was estimated, indicating successful imprinting of the TZD molecules within the polymeric matrix. The analytical response was linear in the range of 5–80 µM, and an LOD of 1.6 µM was estimated. Selectivity was evaluated by testing the sensor for molecules with a similar structure to TZD, and the ability of MIP/SPCE to selectively bind to TZD was proven. The sensor was applied to spiked tap water samples and human serum with good recoveries and allowed for a fast analysis (around 30 min).

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Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

2022

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Environmental problems of great complexity arise from the enormous number of toxic substances that are generated by anthropogenic activities. Seemingly, society encounters new issues every day thus these problems seem to be endless. Now in the face of the COVID‐19 pandemic and the SARS‐CoV‐2 crisis, a large number of emerging treatment compounds generated by pharmaceutical companies worldwide makes future issues even more treacherous. For this reason, there is an increasing need to detect and treat emerging compounds to prevent them from becoming persistent pollutants. This review describes the advances in the use of electrochemical sensors with modified carbon‐based electrodes among other issues, to determine antibiotics, anti‐inflammatories and antidepressants levels in the environment. It further explores technologies suggested for cleaning wastewater polluted by pharmaceutical products using biological or advanced oxidation processes including photolysis, photocatalysis, microwave heating, ultrasound, Fenton, electro‐Fenton, photoelectro‐Fenton and various combined treatments.

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Using magnetic nanoparticles/MIP-based electrochemical sensor for quantification of tetracycline in milk samples

Cited by 51 publications

References 32 publications

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

Electropolymerized, Molecularly Imprinted Polymer on a Screen-Printed Electrode—A Simple, Fast, and Disposable Voltammetric Sensor for Trazodone

Detection and Treatment of Persistent Pollutants in Water: General Review of Pharmaceutical Products

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