Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy

Lin, Yen-Pin; Hsieh, Yi-Shan; Cheng, Mei-Hsiu; Shen, Ching‐Fen; Shen, Ching‐Ju; Cheng, Chao‐Min

doi:10.3390/vaccines10101681

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…IgG antibodies to the SARS-CoV-2 virus cross the placenta, which is why immunization against this virus is recommended for women in the reproductive period [ 75 ]. Comparing vaccinated and unvaccinated gravid women, Lin et al detected different expressions of the seven miRNAs [ 76 ]. It was stated that miRNA-1972, miRNA-191-5p, and miRNA-423-5p were overexpressed in the vaccinated, and miRNA-16-5p, miRNA-486-5p, miRNA-21-5p, and miRNA-451a were overexpressed in unvaccinated pregnant women [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

“…Comparing vaccinated and unvaccinated gravid women, Lin et al detected different expressions of the seven miRNAs [ 76 ]. It was stated that miRNA-1972, miRNA-191-5p, and miRNA-423-5p were overexpressed in the vaccinated, and miRNA-16-5p, miRNA-486-5p, miRNA-21-5p, and miRNA-451a were overexpressed in unvaccinated pregnant women [ 76 ]. New technologies produced vaccines that contain messenger RNA (mRNA) of the spike protein from the surface of the SARSC-CoV-2 virus.…”

Section: Resultsmentioning

confidence: 99%

“…New technologies produced vaccines that contain messenger RNA (mRNA) of the spike protein from the surface of the SARSC-CoV-2 virus. As these vaccines do not contain the virus, and the host’s cells decompose the mRNA in several days, it is considered that mRNA vaccines are the most suitable for use during pregnancy [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

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miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome

et al. 2023

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During the last three years, since the emergence of the COVID-19 pandemic, a significant number of scientific publications have focused on resolving susceptibility to the infection, as well as the course of the disease and potential long-term complications. COVID-19 is widely considered as a multisystem disease and a variety of socioeconomic, medical, and genetic/epigenetic factors may contribute to the disease severity and outcome. Furthermore, the SARS-COV-2 infection may trigger pathological processes and accelerate underlying conditions to clinical entities. The development of specific and sensitive biomarkers that are easy to obtain will allow for patient stratification, prevention, prognosis, and more individualized treatments for COVID-19. miRNAs are proposed as promising biomarkers for different aspects of COVID-19 disease (susceptibility, severity, complication course, outcome, and therapeutic possibilities). This review summarizes the most relevant findings concerning miRNA involvement in COVID-19 pathology. Additionally, the role of miRNAs in wide range of complications due to accompanied and/or underlying health conditions is discussed. The importance of understanding the functional relationships between different conditions, such as pregnancy, obesity, or neurological diseases, with COVID-19 is also highlighted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome

et al. 2023

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“…Specific miRNAs can be incorporated into anti-viral drug and vaccine designs to improve their efficacy. Targeting miRNAs involved in immune cell differentiation and function could make it possible to boost the efficacy of vaccines targeting EBOV [68,69]. Our understanding of how specific miRNAs regulate pathways in Ebola pathogenesis such as viral replication, immune evasion, and cell death is very important.…”

Section: Discussionmentioning

confidence: 99%

Identification and Potential Roles of Human MicroRNAs in Ebola Virus Infection and Disease Pathogenesis

Mensah-Bonsu,

Doss,

Gloster

et al. 2024

Genes

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Ebola virus (EBOV) is a highly pathogenic virus that causes a severe illness called Ebola virus disease (EVD). EVD has a high mortality rate and remains a significant threat to public health. Research on EVD pathogenesis has traditionally focused on host transcriptional responses. Limited recent studies, however, have revealed some information on the significance of cellular microRNAs (miRNAs) in EBOV infection and pathogenic mechanisms, but further studies are needed. Thus, this study aimed to identify and validate additional known and novel human miRNAs in EBOV-infected adult retinal pigment epithelial (ARPE) cells and predict their potential roles in EBOV infection and pathogenic mechanisms. We analyzed previously available small RNA-Seq data obtained from ARPE cells and identified 23 upregulated and seven downregulated miRNAs in the EBOV-infected cells; these included two novel miRNAs and 17 additional known miRNAs not previously identified in ARPE cells. In addition to pathways previously identified by others, these miRNAs are associated with pathways and biological processes that include WNT, FoxO, and phosphatidylinositol signaling; these pathways were not identified in the original study. This study thus confirms and expands on the previous study using the same datasets and demonstrates further the importance of human miRNAs in the host response and EVD pathogenesis during infection.

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Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19

Smail,

Hirmiz,

Ahmed

et al. 2024

Front. Med.

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The pandemic of coronavirus disease-19 (COVID-19), provoked by the appearance of a novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), required a worldwide healthcare emergency. This has elicited an immediate need for accelerated research into its mechanisms of disease, criteria for diagnosis, methods for forecasting outcomes, and treatment approaches. microRNAs (miRNAs), are diminutive RNA molecules, that are non-coding and participate in gene expression regulation post-transcriptionally, having an important participation in regulating immune processes. miRNAs have granted substantial interest in their impact on viral replication, cell proliferation, and modulation of how the host’s immune system responds. This narrative review delves into host miRNAs’ multifaceted roles within the COVID-19 context, highlighting their involvement in disease progression, diagnostics, and prognostics aspects, given their stability in biological fluids and varied expression profiles when responding to an infection. Additionally, we discuss complicated interactions between SARS-CoV-2 and host cellular machinery facilitated by host miRNAs revealing how dysregulation of host miRNA expression profiles advances viral replication, immune evasion, and inflammatory responses. Furthermore, it investigates the potential of host miRNAs as therapeutic agents, whether synthetic or naturally occurring, which could be harnessed to either mitigate harmful inflammation or enhance antiviral responses. However, searching more deeply is needed to clarify how host’s miRNAs are involved in pathogenesis of COVID-19, its diagnosis processes, prognostic assessments, and treatment approaches for patients.

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Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy

Cited by 3 publications

References 20 publications

miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome

miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome

Identification and Potential Roles of Human MicroRNAs in Ebola Virus Infection and Disease Pathogenesis

Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19

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