Using monoamine oxidase type B inhibitors in Parkinson's disease

Ben‐Shlomo, Yoav; Bhatia, Kailash

doi:10.1136/bmj.329.7466.581

Cited by 17 publications

(4 citation statements)

References 11 publications

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“…Identification of MAO inhibitors is of great interest in drug discovery (Kalgutkar et al, 2001;Yan et al, 2004). MAO A inhibitors have been used as antidepressants (Nolen et al, 1993), and MAO B inhibitors in the treatment and prevention of Parkinson's disease (Ben-Shlomo and Bhatia, 2004). The oxidation of biogenic amines by MAO results in the production of hydrogen peroxide and aldehydes which may represent a risk factor for cell oxidative injury (Cohen et al, 1997;Hauptmann et al, 1996;Vindis et al, 2000;Youdim and Lavie, 1994).…”

Section: Introductionmentioning

confidence: 99%

Human monoamine oxidase enzyme inhibition by coffee and β-carbolines norharman and harman isolated from coffee

Herraiz¹,

Chaparro²

2006

Life Sciences

127

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Section: Introductionmentioning

confidence: 99%

Human monoamine oxidase enzyme inhibition by coffee and β-carbolines norharman and harman isolated from coffee

Herraiz¹,

Chaparro²

2006

Life Sciences

127

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“…There was concern, for example, about the utility of transplantation and second transplantations [ 32 , 53 ]. In a similar vein, there was discussion about whether risk factors such as alcoholism should be taken into account in access to transplantation [ 54 , 55 ]. Also widely discussed was how gender, ethnic, geographic and socio-economic differences affect access to transplantation [ 37 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

How is organ transplantation depicted in internal medicine and transplantation journals

et al. 2013

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BackgroundIn their book Spare Parts, published in 1992, Fox and Swazey criticized various aspects of organ transplantation, including the routinization of the procedure, ignorance regarding its inherent uncertainties, and the ethos of transplant professionals. Using this work as a frame of reference, we analyzed articles on organ transplantation published in internal medicine and transplantation journals between 1995 and 2008 to see whether Fox and Swazey’s critiques of organ transplantation were still relevant.MethodsUsing the PubMed database, we retrieved 1,120 articles from the top ten internal medicine journals and 4,644 articles from the two main transplantation journals (Transplantation and American Journal of Transplantation). Out of the internal medicine journal articles, we analyzed those in which organ transplantation was the main topic (349 articles). A total of 349 articles were randomly selected from the transplantation journals for content analysis.ResultsIn our sample, organ transplantation was described in positive terms and was presented as a routine treatment. Few articles addressed ethical issues, patients’ experiences and uncertainties related to organ transplantation. The internal medicine journals reported on more ethical issues than the transplantation journals. The most important ethical issues discussed were related to the justice principle: organ allocation, differential access to transplantation, and the organ shortage.ConclusionOur study provides insight into representations of organ transplantation in the transplant and general medical communities, as reflected in medical journals. The various portrayals of organ transplantation in our sample of articles suggest that Fox and Swazey’s critiques of the procedure are still relevant.

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“…Nonetheless, PP increases with age and is strongly related to the early development of large vessel atherosclerosis (8,9). Increased carotid intima-media thickness (IMT) and carotid and/or iliofemoral plaque are frequent in hypertensive subjects, but their relationship with PP has been rarely studied (10). However, some studies, both cross-sectional and prospective (8)(9)(10)(11)(12)(13)(14)(15), have found an association between PP and carotid IMT and its progression, respectively, as summarised in Table 1.…”

Section: Graham Jacksonmentioning

confidence: 99%

“…Concern has been raised regarding the use of MAO‐B inhibitors and an increase in mortality. A meta‐analysis of the use of these drugs in early disease, however, allayed these concerns (9), but the recommendation seems to be that these drugs are safe for use as a monotherapy in young and generally well PD patients (10). In practice, the majority of the PD patients are older and get frail as the disease advances.…”

mentioning

confidence: 99%