Using myelin water imaging to link underlying pathology to clinical function in multiple sclerosis: A scoping review

Edwards, Erin M.; Wu, Wendy; Fritz, Nora

doi:10.1016/j.msard.2022.103646

Cited by 7 publications

(10 citation statements)

References 60 publications

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“…The advantages of MWI are the relatively high reproducibility and specificity for myelin. While brain MWI has already made several contributions to the understanding of structure vs function relationships in MS (see ( Edwards et al, 2022 ) for a review), there remains room for applying the same designs in the SC. ( Lee et al, 2020 ) point out several barriers to the further deployment of MWI, including the limited vendor availability of most advanced sequences, and the complexity of the post-processing.…”

Section: Advanced Imaging Methodsmentioning

confidence: 99%

Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Combes

Clarke

O’Grady

et al. 2022

NeuroImage: Clinical

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Section: Advanced Imaging Methodsmentioning

confidence: 99%

Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Combes

Clarke

O’Grady

et al. 2022

NeuroImage: Clinical

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“…A recent review highlights the applicability of MWI in investigating the clinical correlates of myelin damage in MS [32]. Of note, MWI has recently been shown to reflect cognitive disability because of MS.…”

Section: Multiple Sclerosismentioning

confidence: 99%

Update on myelin imaging in neurological syndromes

Balaji¹,

Johnson²,

Dvorak

et al. 2022

Current Opinion in Neurology

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Purpose of reviewMyelin water imaging (MWI) is generally regarded as the most rigorous approach for noninvasive, in-vivo measurement of myelin content, which has been histopathologically validated. As such, it has been increasingly applied to neurological diseases with white matter involvement, especially those affecting myelin. This review provides an overview of the most recent research applying MWI in neurological syndromes.Recent findingsMyelin water imaging has been applied in neurological syndromes including multiple sclerosis, Alzheimer's disease, Huntington's disease, traumatic brain injury, Parkinson's disease, cerebral small vessel disease, leukodystrophies and HIV. These syndromes generally showed alterations observable with MWI, with decreased myelin content tending to correlate with lower cognitive scores and worse clinical presentation. MWI has also been correlated with genetic variation in the APOE and PLP1 genes, demonstrating genetic factors related to myelin health.SummaryMWI can detect and quantify changes not observable with conventional imaging, thereby providing insight into the pathophysiology and disease mechanisms of a diverse range of neurological syndromes.

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“…In this regard, advanced MRI sequences have been developed. Techniques such as diffusion tensor imaging (DTI), magnetization transfer ratio (MTR), and myelin water fraction (MWF) are sufficiently sensitive techniques to allow the detection and quantification of myelin content and brain microstructural tissue integrity, and are able to predict cognitive impairment [ 75 ], disability progression [ 76 ], and decreased intervention response in patients with MS related to progression [ 77 ].…”

Section: Modality Of Progression Assessment In the Clinical Settingmentioning

confidence: 99%

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis

et al. 2022

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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) resulting in demyelination and neurodegeneration. The therapeutic strategy is now largely based on reducing inflammation with immunosuppressive drugs. Unfortunately, when disease progression is observed, no drug offers neuroprotection apart from its anti-inflammatory effect. In this review, we explore current knowledge on the assessment of neurodegeneration in MS and look at putative targets that might prove useful in protecting the axon from degeneration. Among them, Bruton’s tyrosine kinase inhibitors, anti-apoptotic and antioxidant agents, sex hormones, statins, channel blockers, growth factors, and molecules preventing glutamate excitotoxicity have already been studied. Some of them have reached phase III clinical trials and carry a great message of hope for our patients with MS.

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Using myelin water imaging to link underlying pathology to clinical function in multiple sclerosis: A scoping review

Cited by 7 publications

References 60 publications

Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions

Update on myelin imaging in neurological syndromes

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis

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