Using Mеldonium to Improve the Adaptation of Patients With Cardiovascular Disease to the Effects of Heat and Correction of Associated Oxidative Stress

Смирнова, М Д; Svirida, O N; Vitsenya, M V; Кузьмина, А.Е.; Ланкин, В. З.; Tihaze, A.K. Tihaze; Konovalova, G.N. Konovalova; Агеев, Ф Т

doi:10.18565/cardio.2014.7.53-59

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Smirnova et al. 7 studied 56 patients with cardiovascular disease, who were randomized to receive basic therapy or basic therapy plus 500 mg/day meldonium. A marked decrease of systolic blood pressure, a reduction of heart rate during heat, along with a better quality of life score (e.g., visual analogue scale) and improved adaptative responses were noticed in the group of patients treated with meldonium.…”

Section: Clinical Trials Using Meldonium Show Promising Results In Pamentioning

confidence: 99%

Misuse of the metabolic modulator meldonium in sports

Lippi

Mattiuzzi²

2017

Journal of Sport and Health Science

View full text Add to dashboard Cite

Section: Clinical Trials Using Meldonium Show Promising Results In Pamentioning

confidence: 99%

Misuse of the metabolic modulator meldonium in sports

Lippi

Mattiuzzi²

2017

Journal of Sport and Health Science

View full text Add to dashboard Cite

“…Drugs of different chemical nature are widely used for pharmacological correction of oxidative stress (Karneev 2007). The chemical structure of a substance determines its targets of action in correcting oxidative stress (Smirnova 2014). Accordingly, taking this relationship into account may be useful when searching for new groups of drugs for correcting oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological screening of substances with cardioprotective effect in the group of 3-oxypyridine derivatives

Даниленко¹,

Skachilova²,

Nadezhdin³

et al. 2018

RRP

View full text Add to dashboard Cite

Citation: Danilenko LM, Skachilova SYa, Nadezhdin SV, Timokhina AS, Shcheblykina OV, Kotelnikova AS (2018) Pharmacological screening of substances with cardioprotective effect in the group of 3-oxypyridine derivatives. Research Results in Pharmacology 4(2): 125-131. https://doi. AbstractIntroduction: The search for new compounds with antihypoxic and cardioprotective effects among 3-oxypyridine derivatives is promising. Research objectives:To study the anti-hypoxic and cardioprotective effects of 3-oxypyridine derivatives. Materials and methods:The search for compounds with an antihypoxic effect was carried out on blood leukocytes of rats in in vitro. To simulate hypoxia, Oil for Tissue Culture (SAGE) was used, 500 µl of which was applied into wells over a growth medium in order to block gas exchange. The cardioprotective effect of 3-oxypyridine derivatives was studied in the model of coronary-occlusive myocardial infarction (30 minutes of ischemia, 90 minutes of reperfusion). The level of troponin I (Tn I) was determined as a biochemical marker of myocardial damage. Results and discussion:In the in vitro experiments, when culting white blood cells, the lead compound in the group of 3-oxypyridine derivatives was identified under code LKhT 21-16, which increases the number of viable cells in the presence of hypoxia, surpassing the reference drugs. When confirming the chemical structure of the lead compound, LHT 21-16, a high sensitivity of the NMR spectroscopy method was revealed.In studying the cardioprotective activity in the model of coronary-occlusive myocardial infarction compound LHT 21-16 exerted a marked cardioprotective effect when reducing the size of the necrotic zone and the level of biochemical marker Tn I. Conclusions:3-oxypiridine derivatives have antihypoxic and cardioprotective effects, which shows in a high number of surviving cells in the presence of hypoxia in the in vitro model, a reduced size of the necrotic zone and a reduced level of Tn I in the coronary-occlusive myocardial infarction.

show abstract

Weather Dependence: A Myth or Reality? A Case Study for Arterial Hypertension

Smirnova,

Ageev

2024

Russ. Meteorol. Hydrol.

View full text Add to dashboard Cite

Using Mеldonium to Improve the Adaptation of Patients With Cardiovascular Disease to the Effects of Heat and Correction of Associated Oxidative Stress

Cited by 5 publications

References 0 publications

Misuse of the metabolic modulator meldonium in sports

Misuse of the metabolic modulator meldonium in sports

Pharmacological screening of substances with cardioprotective effect in the group of 3-oxypyridine derivatives

Weather Dependence: A Myth or Reality? A Case Study for Arterial Hypertension

Contact Info

Product

Resources

About