Using negative pressure wound therapy on microskin autograft wounds

Zhang, Fang; Lv, Kaiyang; Qiu, Xiaochen; Luo, Pan; Zheng, Xianyou; Zhu, Shan; Xia, Zhaofan

doi:10.1016/j.jss.2014.12.025

Cited by 15 publications

(11 citation statements)

References 33 publications

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Section: Resultsmentioning

confidence: 99%

“…Following an assessment of 509 relevant papers, 14 studies that were released between 2014 and 2022 were included in the meta‐analysis since they matched the inclusion criteria. 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 Table 2 summarizes the findings of these investigations. A total of 18 410 people were tested for nasal colonization after SS.…”

Section: Resultsmentioning

confidence: 99%

“…The sample size was 247-356 people. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] The examined data revealed that MRSA-positive had a significantly higher SSI compared with MRSA-negative in SS subjects.…”

Section: Discussionmentioning

confidence: 99%

“…For the current meta‐analysis, 14 exams from 2014 to 2022 were included; of these, 18 410 people were tested for nasal colonization after SS. The sample size was 247–356 people 8–21,34–49 . The examined data revealed that MRSA‐positive had a significantly higher SSI compared with MRSA‐negative in SS subjects.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of surgical site wound infection after spine surgery in nasal colonization of methicillin‐resistant Staphylococcus aureus: A meta‐analysis

Imam,

Abdel‐Sattar,

Alqarni

et al. 2023

International Wound Journal

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The purpose of the meta‐analysis was to evaluate and compare the prevalence of surgical site infection (SSI) after spine surgery (SS) in nasal colonization of methicillin‐resistant Staphylococcus aureus (MRSA). The results of this meta‐analysis were analysed, and the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random‐ or fixed‐effect models. For the current meta‐analysis, 14 examinations spanning from 2014 to 2022 were included, encompassing 18 410 people who were tested for nasal colonization after SS. MRSA‐positive had a significantly higher SSI (OR, 3.65; 95% CI, 2.48–5.37, p < 0.001) compared with MRSA‐negative in SS subjects. However, no significant difference was found between methicillin‐susceptible Staphylococcus aureus and Staphylococcus aureus negative (OR, 0.94; 95% CI, 0.32–2.79, p = 0.91), and Staphylococcus aureus positive and negative (OR, 2.13; 95% CI, 0.26–17.41, p = 0.48) in SS subjects. The examined data revealed that MRSA colonization had a significant effect on SSI; however, methicillin‐susceptible Staphylococcus aureus and Staphylococcus aureus had no significant effect on SSI in SS subjects. However, given that some comparisons included a small number of chosen studies, attention should be given to their values.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of surgical site wound infection after spine surgery in nasal colonization of methicillin‐resistant Staphylococcus aureus: A meta‐analysis

Imam,

Abdel‐Sattar,

Alqarni

et al. 2023

International Wound Journal

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“…Other advantages have been noted in regard to reduced time to total healing, 6,23,28,29 reduced regrafting procedures, [30][31][32] reduced length of hospital stay 30 and reduced infection rate. 33 The free radial forearm donor site has been studied by multiple groups (Table 2). [34][35][36][37][38] The majority of these studies do not show a significant improvement in graft take, though other advantages have been reported including improved early function.…”

Section: Npwt For Ssgmentioning

confidence: 99%

Postoperative management of lower limb split-thickness skin grafts in Australia

Ellis¹,

Terrill

Miller

et al. 2020

Australas J Plast Surg

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Background: Evidence for postoperative management of split-thickness skin grafts (SSGs) to lower leg wounds has shown early mobilisation has no adverse effects on graft take, while improving patient outcomes and significantly reducing hospitalisation costs. The development of negative-pressure wound therapy (NPWT) for SSGs led to new options for bolster dressings. This study aimed to determine the current postoperative mobilisation and dressing choices of Australian plastic surgeons. Methods: Australian plastic surgeons were invited electronically to participate in a questionnaire regarding their postoperative regimens for lower limb SSG in 2013, and again in 2018. A literature review was performed to establish whether surgeon-reported practice was in line with current evidence for early mobilisation of lower limb SSGs and also for NPWT on SSGs. Results: In 2013, 119 responses were received and in 2018, 110 responses were received. Survey responses showed significant reductions in the numbers of patients kept immobilised for more than five days (30% to 9%, p = 0.001) between 2013 and 2018. Surgeons reported immobilising their patients longer with standard dressings than with NPWT dressings (p = 0.003 by multinomial logistic regression). More than two-thirds of surgeons reported NPWT use in both 2013 (66%) and 2018 (70%). Conclusion: Between 2013 and 2018, NPWT use increased slightly and the percentage of surgeons mobilising their patients early significantly increased, in accordance with evidence in the literature. A link was noted between NPWT use and an increased tendency to early mobilisation. However, a large proportion of surgeons continued to prescribe bed rest postoperatively.

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TLQP-21 facilitates diabetic wound healing by inducing angiogenesis through alleviating high glucose-induced injuries on endothelial progenitor cells

Fang,

Zhu,

Zhang

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Diabetes mellitus (DM) is a metabolic disease with multiple complications, including diabetic cutaneous wounds, which lacks effective treating strategies and severely influences the patients’ life. Endothelial progenitor cells (EPCs) are reported to participate in maintaining the normal function of blood vessels, which plays a critical role in diabetic wound healing. TLQP-21 is a VGF-derived peptide with promising therapeutic functions on DM. Herein, the protective effects of TLQP-21 on diabetic cutaneous wound and the underlying mechanism will be investigated. Cutaneous wound model was established in T2DM mice, followed by administering 120 nmol/kg and 240 nmol/kg TLQP-21 once a day for 12 days. Decreased wound closure, reduced number of capillaries and EPCs, declined tube formation function of EPCs, and inactivated PI3K/AKT/eNOS signaling in EPCs were observed in T2DM mice, which were sharply alleviated by TLQP-21. Normal EPCs were extracted from mice and stimulated by high glucose (HG), followed by incubated with TLQP-21 in the presence or absence of LY294002, an inhibitor of PI3K. The declined cell viability, increased apoptotic rate, reduced number of migrated cells, declined migration distance, repressed tube formation function, and inactivated PI3K/AKT/eNOS signaling observed in HG-treated EPCs were markedly reversed by TLQP-21, which were dramatically abolished by the co-culture of LY294002. Collectively, TLQP-21 facilitated diabetic wound healing by inducing angiogenesis through alleviating HG-induced injuries on EPCs.

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Using negative pressure wound therapy on microskin autograft wounds

Cited by 15 publications

References 33 publications

Prevalence of surgical site wound infection after spine surgery in nasal colonization of methicillin‐resistant Staphylococcus aureus: A meta‐analysis

Prevalence of surgical site wound infection after spine surgery in nasal colonization of methicillin‐resistant Staphylococcus aureus: A meta‐analysis

Postoperative management of lower limb split-thickness skin grafts in Australia

TLQP-21 facilitates diabetic wound healing by inducing angiogenesis through alleviating high glucose-induced injuries on endothelial progenitor cells

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