2024
DOI: 10.1007/s10911-024-09559-z
|View full text |Cite
|
Sign up to set email alerts
|

Using Organoids to Tap Mammary Gland Diversity for Novel Insight

Gat Rauner

Abstract: This article offers a comprehensive perspective on the transformative role of organoid technology on mammary gland biology research across a diverse array of mammalian species.The mammary gland's unique development and regenerative capabilities render this organ an ideal model for studying developmental evolution, stem cell behavior, and regenerative processes. The discussion extends to the use of cross-species mammary organoids to address key biological inquiries in evolution, tissue regeneration, cancer rese… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(2 citation statements)
references
References 105 publications
0
2
0
Order By: Relevance
“…This observation, together with the well-documented histo-anatomical similarities of the sheep mammary gland to the human breast (Hughes, 2021b;Nagy et al, 2021;Rowson et al, 2012) indicate that the male sheep mammary gland may be a useful adjunctive model of the male human breast. As mammary tumourigenesis is rare in sheep (Hughes, 2021b;Newman et al, 2021;Rauner, 2024), the male ovine gland does not offer a direct model for male breast cancer, but it will facilitate furthering understanding of normal male mammary biology to use in comparative studies. In addition, the relative resistance of the sheep to development of mammary tumours may be a further fruitful avenue of future comparative study (Hughes, 2023).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This observation, together with the well-documented histo-anatomical similarities of the sheep mammary gland to the human breast (Hughes, 2021b;Nagy et al, 2021;Rowson et al, 2012) indicate that the male sheep mammary gland may be a useful adjunctive model of the male human breast. As mammary tumourigenesis is rare in sheep (Hughes, 2021b;Newman et al, 2021;Rauner, 2024), the male ovine gland does not offer a direct model for male breast cancer, but it will facilitate furthering understanding of normal male mammary biology to use in comparative studies. In addition, the relative resistance of the sheep to development of mammary tumours may be a further fruitful avenue of future comparative study (Hughes, 2023).…”
Section: Discussionmentioning
confidence: 99%
“…Expansion of the diversity of mammary gland models has been recently highlighted as an opportunity to develop our understanding of mammary functions and phenotypes that cannot be addressed using traditional models (Rauner, 2024). Sheep are commonly used to model human fetal development (Morrison et al, 2018) and we and others have noted anatomical similarities in mammary terminal duct lobular unit (TDLU) structure and stromal composition between the sheep mammary gland and the female breast (Hovey et al, 1999;Hughes, 2021b;Hughes & Watson, 2018;Nagy et al, 2021;Rowson et al, 2012).…”
Section: Introductionmentioning
confidence: 99%