Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic

Baud, David; Agri, Varvara Dimopoulou; Gibson, Glenn R.; Reid, Gregor; Giannoni, Éric

doi:10.3389/fpubh.2020.00186

Cited by 220 publications

(246 citation statements)

References 52 publications

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“…Immune cells travel from gut to lung through the common mucosal immune system [13]. Gut immunity imbalance due to gut microbiota perturbation may affect immune responses at the lung level [13,33]. Furthermore, gut microbial metabolites such as short-chain fatty acids (SCFAs) act as crucial local and systemic signaling molecules in maintaining immune homeostasis [34].…”

Section: Gut-lung Axis and Viral Respiratory Infectionsmentioning

confidence: 99%

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

et al. 2020

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Inflammation is a biological response to the activation of the immune system by various infectious or non-infectious agents, which may lead to tissue damage and various diseases. Gut commensal bacteria maintain a symbiotic relationship with the host and display a critical function in the homeostasis of the host immune system. Disturbance to the gut microbiota leads to immune dysfunction both locally and at distant sites, which causes inflammatory conditions not only in the intestine but also in the other organs such as lungs and brain, and may induce a disease state. Probiotics are well known to reinforce immunity and counteract inflammation by restoring symbiosis within the gut microbiota. As a result, probiotics protect against various diseases, including respiratory infections and neuroinflammatory disorders. A growing body of research supports the beneficial role of probiotics in lung and mental health through modulating the gut-lung and gut-brain axes. In the current paper, we discuss the potential role of probiotics in the treatment of viral respiratory infections, including the COVID-19 disease, as major public health crisis in 2020, and influenza virus infection, as well as treatment of neurological disorders like multiple sclerosis and other mental illnesses.

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Section: Gut-lung Axis and Viral Respiratory Infectionsmentioning

confidence: 99%

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

et al. 2020

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“…Clinical evidence demonstrates that certain probiotic strains support the prevention of viral infections of the respiratory tract [ 109 , 113 , 115 , 116 ], as is the case of COVID-19. Particularly, studies show that patients on mechanical ventilation who were administered probiotics had significantly less ventilator-associated pneumonia [ 117 , 118 ].…”

Section: Therapeutic Opportunities For Covid-19 With Impact On Thementioning

confidence: 99%

“…Particularly, studies show that patients on mechanical ventilation who were administered probiotics had significantly less ventilator-associated pneumonia [ 117 , 118 ]. Additionally, probiotic strains have been shown to modify the balance between proinflammatory and immunoregulatory cytokines [ 116 ], which allows viral clearance, while minimizing immune response-mediated lung damage. These observations might be particularly relevant in the context of ventilation-associated pneumonia, cytokine storm, and ARDS, all features of COVID-19.…”

Section: Therapeutic Opportunities For Covid-19 With Impact On Thementioning

confidence: 99%

“…However, clinical trials are being performed in order to evaluate the effects of probiotics on the microbiome of household contacts exposed to COVID-19 (Clinical Trial gov Identifier NCT04399252, 2020) and their usefulness in the prevention and treatment of COVID-19 (Clinical Trial gov Identifiers NCT04366180, NCT04366089, NCT04368351). Without current science-based recommendations of prebiotics, probiotics, and synbiotics to manage COVID-19, the use of these supplements as adjunctive therapy may help to enhance host immunity and possibly better face (or prevent) the SARS-CoV-2 infection [ 115 , 116 ].…”

Section: Therapeutic Opportunities For Covid-19 With Impact On Thementioning

confidence: 99%

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Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

2020

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Coronavirus Disease 2019 (COVID-19) is a pandemic infection caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients present a complex clinical picture that, in severe cases, evolves to respiratory, hepatic, gastrointestinal, and neurological complications, and eventually death. The underlying pathophysiological mechanisms are complex and multifactorial and have been summarized as a hyperresponse of the immune system that originates an inflammatory/cytokine storm. In elderly patients, particularly in those with pre-existing cardiovascular, metabolic, renal, and pulmonary disorders, the disease is particularly severe, causing prolonged hospitalization at intensive care units (ICU) and an increased mortality rate. Curiously, the same populations have been described as more prone to a gut microbiota (GM) dysbiosis profile. Intestinal microflora plays a major role in many metabolic and immune functions of the host, including to educate and strengthen the immune system to fight infections, namely of viral origin. Notably, recent studies suggest the existence of GM dysbiosis in COVID-19 patients. This review article highlights the interplay between the triad GM dysbiosis–immune hyperresponse–inflammation in the individual resilience/fragility to SARS-CoV-2 infection and presents the putative impact of pharmacological and nutraceutical approaches on the triumvirate, with focus on GM.

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“…Потребление пробиотиков повышает уровень интерферонов типа I, антигенпрезентирующих клеток, NK-клеток, а также Т-и В-клеток в иммунной системе легких. Введение пробиотиков также может улучшить про-и противовоспали тельные цитокины, помогая избавиться от вирусной инфекции, сводя к минимуму повреждение клеток в легких [92]. Этот предложенный механизм также может быть использован для предотвращения осложнений, связанных с COVID-19.…”

Section: пробиотики обладают противовирусной активностьюunclassified

Immunomodulatory effects of probiotics

Plotnikova

Zakharova

2020

Medicinskij sovet

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Today, there is an explosion of discoveries related to a growing understanding of the role of microbial communities, key species of bacteria, products or metabolites derived from commensals, and in particular the relationship between some of these components and painful conditions in humans. Microbiota plays a fundamental role in the induction, training and functioning of the host’s immune system. In turn, the immune system has evolved significantly as a means of maintaining the host’s symbiotic relations with these very diverse and developing microbes. At optimal performance, this alliance of the immune system and microbiota allows to induce protective reactions to pathogens and maintain regulatory pathways involved in maintaining tolerance to harmless antigens. In this review, we outline the role of the intestinal microbiota in the immune system, starting with initial information supporting further insights into the effects of intestinal microbiota dysbacteriosis on the host’s susceptibility to infection. Probiotics are considered a good form of therapy to control harmful intestinal microorganisms, improve digestion and the absorption of nutrients. The beneficial effects of probiotics have been demonstrated in many diseases. One of the main mechanisms of probiotics is the regulation of the immune response of the host. The article reviews and discusses the regulatory role of probiotics in the “intestine-lungs” system and the immune system of mucous membranes for potential antiviral mechanisms. The unique role of probiotics in modulation of intestinal microbes and establishment of intestinal homeostasis and production of interferon as antiviral mechanism is described. In addition, the regulatory role of probiotics in the system «intestine-lungs» and the immune system of the mucous membranes for potential antiviral mechanisms, including in COVID-19 is considered and discussed. Symbiotic products Bac-Set® Forte and Bac-Set® Cold/Flu are described.

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Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic

Cited by 220 publications

References 52 publications

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

Immunomodulatory effects of probiotics

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