Using terahertz pulse spectroscopy to study the crystalline structure of a drug: A case study of the polymorphs of ranitidine hydrochloride

Taday, Philip F.; Bradley, I. V.; Arnone, D. D.; Pepper, M.

doi:10.1002/jps.10358

Cited by 308 publications

(194 citation statements)

References 18 publications

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“…However, advances over the last decade in lasers and semiconductors have opened up tremendous opportunities in this region. In recent years, THz time-domain spectroscopy (THz-TDS) based on femtosecond laser technology has been considered as a competitive tool for medical diagnosis [3][4][5], pharmaceutical characterization [6][7][8], and security applications [9,11] because THz-TDS is strikingly sensitive not only to the biological molecule itself but also to its surrounding environment.…”

Section: Introductionmentioning

confidence: 99%

First principles investigation of L-alanine in terahertz region

Zheng

Wang

2012

J Biol Phys

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Terahertz absorption spectrum (0.5-4.0 THz) of L-alanine in the solid phase was measured by terahertz time-domain spectroscopy at room temperature. Simulations utilizing gaseous-state and solid-state theory were performed to determine the origins of the observed vibrational features. Our calculations showed that the measured features in solidstate materials could be well understood by considering the crystal packing interactions in a solid-state density functional theory calculation. Furthermore, intermolecular vibrations of L-alanine are found to be the dominating contributions to these measured spectral features in the range of 0.5-4.0 THz, except that located at 3.11 THz.

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Section: Introductionmentioning

confidence: 99%

First principles investigation of L-alanine in terahertz region

Zheng

Wang

2012

J Biol Phys

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“…THz-TDS is also used for the study of pharmaceutical drugs and is effective to discriminate polymorphic, because several forms of polymorphic drugs show completely different THz spectra. In addition to crystalline polymorphism, amorphous polymorphism also attracts much attention from fundamental physics and application for drug detection [5,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Terahertz Time-Domain Spectroscopy and Low-Frequency Raman Scattering of Crystalline and Glassy Pharmaceutical Indapamide

Kobayashi

Shibata

Mori

et al. 2015

ILCPA

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We performed terahertz time-domain spectroscopy and low-frequency Raman scattering on crystalline and glassy states of pharmaceutical indapamide (IND). We have determined the real and imaginary part of the complex dielectric constants and the imaginary part of the Raman susceptibility in the THz region. Several phonon peaks have been observed in the crystalline IND and the mutual exclusion principle of infrared and Raman spectroscopy holds in the measured frequency range. In a glassy state of IND, a broad absorption peak has been observed in both the THz and the Raman spectra with different spectral shape, and this disagreement indicates that the far-infrared and Raman lightvibration coupling constants are different in the glassy IND. A clear boson peak has been observed in the Raman spectra of the glassy IND at about 0.5 THz.

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“…In addition, in recent years, terahertz time-domain spectroscopy (THz-TDS) , utilizing femtosecond lasers as the excitation source, has been developed. THz-TDS enabled us to obtain absorption and dispersion spectra with a high signal-to-noise ratio in a frequency region less than 3 THz (100 cm -1 ) and can be applied for absorption spectroscopy of various substances (Kawase et al, 2009;Korter et al, 2006;Taday et al, 2003;Tani et al, 2004;Walther et al, 2003;Yamamoto et al, 2005;Yamaguchi et al, 2005) and imaging measurements (Kawase, 2004). There is a keen interest in low frequency vibrational spectroscopy for biomolecules since large amplitude, low frequency modes in macro biomolecules are believed to be associated with their respective function, as in the case of proteins (Chou, 1985(Chou, , 1988.…”

Section: Introductionmentioning

confidence: 99%