Using the Atherogenic Index of Plasma to Estimate the Prevalence of Ischemic Stroke within a General Population in a Rural Area of China

Abstract

Objective. To investigate the relationship between the atherogenic index of plasma (AIP) and ischemic stroke. Design. We collected a range of data from 11,495 residents (aged ≥35 years; 54.28% female) residing in rural areas of northeast China between January and August 2013, including fasting lipid profile and anthropometric parameters. Logistic regression models were used to evaluate the correlation between AIP and ischemic stroke. Category-free analysis was used to determine whether AIP enhanced our capacity to estimate ischemic stroke. Results. Irrespective of gender, AIP was independently associated with the occurrence of ischemic stroke. The prevalence of ischemic stroke increased significantly from the lowest quartile to the highest quartile (females: 10.5%-48.7%, P < 0.001 ; males: 22.0%-36.5%, P = 0.08 ). After adjusting for age, gender, income, education, smoking, drinking, exercise, hypertension, body mass index (BMI), diabetes, atrial fibrillation, and a family history of stroke, we found that for every 1 standard deviation (SD) increase in AIP, there was a 34.8% and 20.9% increase in the prevalence of stroke for females and males, respectively. Curve fitting was also used to evaluate the linear relationship between AIP and the occurrence of ischemic stroke. Category-free analysis indicated that AIP significantly enhanced our ability to estimate ischemic stroke in both females (NRI (95% confidence interval (CI)): 0.188 (0.105-0.270)) and males (NRI (95% CI): 0.175 (0.017-0.333)). Conclusion. Analyses detected a significant and positive linear relationship between AIP and the prevalence of ischemic stroke. This relationship was independent of a range of conventional risk factors.

Visceral adiposity index and atherogenic index of plasma as useful predictors of risk of cardiovascular diseases: evidence from a cohort study in Iran

“…A positive association between AIP and CVDs has already been observed in different populations, such as postmenopausal women and staff [19,30]. Moreover, AIP is positively associated with non-alcoholic fatty liver disease (NAFLD), advanced subclinical coronary artery disease (CAD), ischemic stroke, atherosclerosis, MetS, and obesity; and is a useful and reliable marker for predicting these diseases [29,[31][32][33][34]. Results of a study on Malaysian population showed that among lipid profile indices, AIP was more positively correlated with TG and was more negatively correlated with HDL-C, thus AIP was considered to be the strongest marker in predicting risk of CVDs among the other indices [30].…”

Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China

“…A multistage, stratified, random cluster sampling was used. The full details of the design and principles of the study were described elsewhere [ 17 – 19 ].…”

Association between Plasma Homocysteine Concentrations and the First Ischemic Stroke in Hypertensive Patients with Obstructive Sleep Apnea: A 7-Year Retrospective Cohort Study from China

“…In China, IS is the most prevalent type of cerebrovascular event. Therefore, the prevention of IS is an important and urgent public health issue [ 6 , 7 , 32 ]. Since the discovery of the association of Hcy with the pathogenesis of atherosclerosis, Hcy-lowering therapies have attracted considerable attention among the various prevention strategies for IS [ 33 , 34 ].…”

“…Researches have demonstrated that ischemic stroke (IS) is the most prevalent stroke subtype in China, accounting for about 70-86% of all strokes [ 2 , 5 ]. Therefore, early identification and management of associated risk factors are critical measures to prevent and treat the first IS [ 6 , 7 ].…”