2019
DOI: 10.3233/cbm-182184
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Using tRNA halves as novel biomarkers for the diagnosis of gastric cancer

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Cited by 66 publications
(87 citation statements)
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“…GC is a very common malignant tumor with a high mortality rate, especially in Southeast Asian countries 1 3 . With the development of modern medicine, the overall survival rate of patients with GC has improved, but most patients with early-stage gastric cancer (EGC) have no obvious characteristic performance 4 , 5 .…”
Section: Introductionmentioning
confidence: 99%
“…GC is a very common malignant tumor with a high mortality rate, especially in Southeast Asian countries 1 3 . With the development of modern medicine, the overall survival rate of patients with GC has improved, but most patients with early-stage gastric cancer (EGC) have no obvious characteristic performance 4 , 5 .…”
Section: Introductionmentioning
confidence: 99%
“…Some studies have reported the effects of circulating tRFs in the diagnosis of epilepsy, clear cell renal cell carcinoma, gastric cancer, and so on. 17,18,28 Most studies directly verified the selected tRFs in tissues or blood, whereas we designed a four-phase study to identify tRFs for the diagnosis of EBC. High-throughput sequencing was applied to identify differentially expressed tRFs and tiRNAs.…”
Section: Discussionmentioning
confidence: 99%
“…TRIzol reagent (Invitrogen) was used to extract total RNA from the HSCC and adjacent normal tissue samples, and a NanoDrop spectrophotometer and an Agilent 2100 Bioanalyzer (Agilent Technologies) were used to measure the RNA concentration and purity, respectively. The amount of RNA was calculated based on 1 OD 260 nm = 40 μg of RNA, and an A260/A280 ratio ranging from 1.8 to 2.1 was used to qualify RNA that could be used in subsequent experiments …”
Section: Methodsmentioning
confidence: 99%