Uso do decanoato de nandrolona (Decadurabolin®) como estimulante da proliferação óssea em cães com consolidação retardada

Ibañez, José Fernando; Silva, T. S.; Pontes, Dar

doi:10.11606/issn.2318-3659.v40isupl.p229-230

Cited by 3 publications

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“…Ocorrem poucas alterações radiográficas quando as radiografias são realizadas em intervalos menores de tempo (LAFAVER et al, 2007;GUERRERO et al, 2011, LANDE et al, 2012. Além disso, outros estudos já utilizaram o intervalo de 21 dias entre as radiografias (IBANEZ et al, 2003;MARQUES et al, 2017).…”

Section: Discussionunclassified

“…O grupo DN apresentou-se com o tempo de consolidação menor em comparação ao grupo controle. Outros estudos já monstraram os efeitos benéficos do DN para acelerar o processo de consolidação óssea (CUNHA et al, 2004;IBANEZ et al, 2003;MARQUES, 2017;SENOS et al, 2019 (LIN et al, 2017;BRAGDON e BAHNEY, 2018;SANGHANI-KERAI et al, 2018;IAQUINTA et al, 2019;XU et al, 2020;SAFAROVA et al, 2020).…”

Section: Discussionunclassified

“…A fosfatase alcalina e a histopatologia óssea são de grande importância para a avaliação da atividade osteoblástica para verificar estimulação e cicatrização óssea (AHMAD et al, 2013;IBANEZ;PONTES, 2003). Em humanos os principais efeitos adversos são aumento no risco de doenças cardiovasculares, neoplasias hepáticas, infertilidade, alterações de comportamento, da próstata e função imunológica.…”

Section: Decanoato De Nandrolonaunclassified

“…O decanoato de nandrolona atua no aumento de massa muscular, pelo aumento da síntese de proteínas, aumento de eritrócitos; produz um efeito positivo no crescimento ósseo pela estimulação da produção do hormônio de crescimento (GH); aumenta a quantidade de matriz óssea e a deposição de sais de cálcio (IBANEZ; SILVA; PONTES, 2003).…”

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>b<Interferência do decanoato de nandrolona associado com células tronco na consolidação óssea do defeito resultante da osteotomia para avanço da tuberosidade tibial em cães>/b<

Marques¹

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Section: Decanoato De Nandrolonaunclassified

Section: ) Introduçãounclassified

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>b<Interferência do decanoato de nandrolona associado com células tronco na consolidação óssea do defeito resultante da osteotomia para avanço da tuberosidade tibial em cães>/b<

Marques¹

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Evaluation of the Effect of Nandrolone Decanoate on Experimental Spinal Cord Injury in Rats

Weizenmann

Viott

Barbosa

et al. 2019

Acta Scientiae. Vet.

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Background: Acute spinal cord injury, a common cause of neurological dysfunction in humans and animals, impairs motor, sensory and autonomic functions and may result in permanent disability. Nandrolone decanoate (ND) is a steroid widely studied for its predominantly anabolic effect and low androgenic potential. Several researchers have described the positive interference of ND in neurological tissue, such as increased synthesis and release of neurotrophic substances, but to date no studies have evaluated the action of this steroid in acute spinal cord injury. The aim of this study was therefore to evaluate the effect of ND in rats subjected to acute spinal cord injury. Materials, Methods & Results: Thirty-two young adult Wistar rats (Rattus norvegicus), weighing between 240 and 260 g, were divided into three groups. The first group (GNAN) (n=13) was subjected to acute spinal cord injury and treated with ND; the control group (GCON) (n=13) was subjected to spinal cord injury without treatment; and the third group (GLAM) (n=6) underwent laminectomy without prior spinal cord injury, in order to control changes caused by the procedure. A 20 g metal device was released from a height of 25 cm to produce the spinal cord injury. After exposing the spinal canal, a 2-mm diameter metal rod was placed directly in contact with the spinal cord, and when the weight was released, the rod was struck, causing the spinal cord injury. An intramuscular injection of 2 mg/kg of ND was administered the immediate postoperative period. The animals were assessed to ascertain the recovery of their motor function on five occasions, namely at 24 h, 48 h, 72 h, 7 and 14 days after undergoing spinal cord injury. This assessment was performed using the Basso, Beattie and Bresnahan (BBB) model. The animals were euthanized 14 days post-op and fragments of the spinal cord and urinary bladder were collected for histological evaluation. Discussion: The animals subjected to spinal cord injury presented paraplegia, failing to score on the BBB scale in the first three assessments. Starting 7 days after surgery, the GNAN (0-13) and GCON (0-5) groups gradually began showing locomotor improvements, with scale variations. On day 14 after spinal cord injury, 22% of the animals in GNAN and 11% in GCON had failed to recover their locomotor function, scoring zero on the BBB scale. After spinal cord injury, all the animals showed urine retention. The urinary function returned on average on day 5 post surgery, with no significant difference between the groups. The locomotor assessment of the animals subjected to acute spinal cord injury revealed that the injury varied in intensity in GNAN and GCON, with signs of pelvic limb paraplegia and asymmetric non-ambulatory paraparesis. Time was a determining factor in the clinical evolution of the animals, with no evidence of the influence of ND. The histological findings revealed variations in the intensity of the injury, with a tendency for lower intensity in the cranial and epicentral segments of the lesion in the animals subjected to ND treatment, albeit without statistically significant evidence (P ≥ 0.05). The spinal cord assessments of the GLAM group indicated that the surgical procedure did not cause histological alterations, since the normal architecture of the neural tissue was preserved. The histopathological evaluations of the urinary bladder revealed an inflammatory response characterized by lymphohistiocytosis and neutrocytosis in the animals of GNAN and GCON, without interference of ND in the change (P ≥ 0.05). The method to elicit spinal cord injury reproduced functional, sensory and motor incapacity heterogeneously in rats. In the dose evaluated here, ND did not significantly influence the return of locomotor function and the intensity of spinal cord histopathological alterations.

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Effects of nandrolone decanoate on time to consolidation of bone defects resulting from osteotomy for tibial tuberosity advancement

Marques¹,

Ibañez²,

Freitas³

et al. 2017

Vet Comp Orthop Traumatol

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SummaryStudy design: Experimental study.Objective: The aim of this study was to evaluate the effect of nandrolone decanoate (ND) on the time taken for bone consolidation in dogs undergoing tibial tuberosity advancement surgery (TTA).Materials and methods: Seventeen dogs that underwent TTA surgery were randomly divided into two groups: group C (TTA; 9 stifles), and group TTA+ND (TTA and systemic administration of ND; 8 stifles). Three observers (two radiologists and an orthopaedic surgeon), assessed bone consolidation by visual inspection of serial radiographs at intervals of 21 days following surgery.Results: There were no differences in median weight and age between groups, nor between the medians of the variables right and left stifle. Only weight and age values were normally distributed. The other variables, right and left stifle and time to consolidation, showed non-normal distribution. Meniscal injury was present in all animals in group C and all animals in group TTA+ND. There was a significant difference between time to consolidation in groups C and TTA+ND (p <0.05). One animal in the group TTA+ND showed increased libido. Kappa agreement among observers on radiographs was 0.87.Conclusion: Administration of ND reduces time to bone consolidation in dogs undergoing TTA.Supplementary Material for this article is available online at https://doi.org/10.3415/VCOT-16-09-0130

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Uso do decanoato de nandrolona (Decadurabolin®) como estimulante da proliferação óssea em cães com consolidação retardada

Abstract: O artigo não apresenta resumo.

Cited by 3 publications

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>b<Interferência do decanoato de nandrolona associado com células tronco na consolidação óssea do defeito resultante da osteotomia para avanço da tuberosidade tibial em cães>/b<

>b<Interferência do decanoato de nandrolona associado com células tronco na consolidação óssea do defeito resultante da osteotomia para avanço da tuberosidade tibial em cães>/b<

Evaluation of the Effect of Nandrolone Decanoate on Experimental Spinal Cord Injury in Rats

Effects of nandrolone decanoate on time to consolidation of bone defects resulting from osteotomy for tibial tuberosity advancement

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