Uterine and Cardiovascular Effects of Ritodrine in Premature Labor

Bieniarz, J; Motew, Martin; Scommegna, Antonio

doi:10.1097/00006250-197207000-00013

Cited by 37 publications

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“…Our results are consistent with those of previous studies, which showed increased FHR by MRA to pregnant women for 130 min [ 51 ] and by ritodrine hydrochloride administration into fetal sheep [ 52 ]. Although the clinical significance of tachycardia in fetuses is unknown [ 25 ], our results implied that MRA at a high dose, 1 h after initiation, significantly induced fetal autonomic changes, that is, the balance of sympathomimetic and parasympathetic responses.…”

Section: Discussionsupporting

confidence: 93%

Effects of maternal ritodrine hydrochloride administration on the heart rate of preterm fetal sheep with intraamniotic inflammation

et al. 2022

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Ritodrine hydrochloride is used for pregnancy prolongation and intrauterine fetal resuscitation. However, its clinical significance in intraamniotic inflammation during preterm labor and intrauterine fetal distress is unclear. We investigated the effects of maternal ritodrine hydrochloride administration (MRA; 200 μg/min for 2 h, followed by 800 μg/min for 2 h after 24 h) on fetal physiological parameters. For this purpose, we used chronically instrumented pregnant sheep at 113–119 d (term = 145 d) of gestation without (Group 1, n = 5) and with (Group 2, n = 5) intraamniotic inflammation induced by lipopolysaccharide injection into the amniotic cavity. The changes in fetal heart rate (FHR) and short-term variability (STV) and long-term variability (LTV) in FHR, fetal blood pressure, and fetal arterial blood gas (FABG) values were measured before and at 1 and 2 h after initiating MRA. Before MRA, all parameters were similar between Groups 1 and 2; however, there was significantly higher STV in Group 2 than in Group 1 before MRA at 800 μg/min, significantly higher partial arterial pressure of carbon dioxide in FABG in Group 2 than in Group 1 before MRA at 200 μg/min, and significantly lower blood glucose (BG) in Group 2 than in Group 1 before MRA at 800 μg/min. One hour after MRA, the FHR, STV, and LTV were significantly higher at 800 μg/min than those at the baseline in Group 1, as determined by the Friedman test; however, no significant difference was observed in Group 2. Additionally, the FABG pH significantly decreased 1 h after MRA at 800 μg/min in Group 2, whereas FABG lactate and BG significantly increased 2 h after MRA at 800 μg/min in Groups 1 and 2. Thus, short-term MRA at 800 μg/min increased the FHR, STV, and LTV significantly; these values were further modified under intraamniotic inflammation.

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Section: Discussionsupporting

confidence: 93%

Effects of maternal ritodrine hydrochloride administration on the heart rate of preterm fetal sheep with intraamniotic inflammation

et al. 2022

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“…We think it is of prime importante to reduce the marked side effects of fl-sympathomimetics because of their limiting action upon the success rate. Previous reports [ 1,2,6,8] have demonstrated that the uterine inhibitory action of ritodrine increases with the doses. The same pattern unfortunately occurs with respect to side effects.…”

Section: Commentsmentioning

confidence: 88%

Verapamil to inhibit the cardiovascular side effects of ritodrine

Rodriguez-Escudero¹,

Aranguren²,

Benito³

1981

Intl J Gynecology & Obste

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Side effects of beta-sympathomimetic drugs are of primary interest in the treatment of preterm labor. Incidence of side effects are dose-dependent, as is the efficacy of the beta-agonist in uterine relaxation. the effect of verapamil (Ca2+) inhibitor with antiarrhythmic action) on ritodrine does not modify the value of ritodrine in prolonging pregnancy, but clearly diminishes the incidence of maternal tachycardia and hypotension. The authors suggest that in the treatment of preterm labor with ritodrine infusion above 200 micrograms/min, the addition of verapamil (dosage, 80-120 micrograms/min) is useful because it substantially reduces the cardiovascular side effects associated with ritodrine hydrochloride.

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“…Many of the β 2 -agonists have found use in tocolytic therapy, particularly in the risk of premature birth or in miscarriage, due to the higher selectivity for inhibition of uterus contractions [46]. Ritodrine is a short-acting β 2agonist with a hydroxyphenol group on a basic nitrogen forming a hydrogen bond.…”

Section: Introductionmentioning

confidence: 99%

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

2020

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Abstractβ2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit different pharmacological properties. In terms of bronchodilatory activity, (R)-enantiomers showed higher activity. The investigation of stereoselectivity in action and disposition of chiral drugs together with the preparation of pure enantiomer drugs calls for efficient stereoselective analytical methods. The overview focuses on the stereoselectivity in pharmacodynamics and pharmacokinetics of β2-agonists and summarizes the stereoselective analytical methods for the enantioseparation of racemic beta-agonists (HPLC, LC-MS, GC, TLC, CE). Some methods of the stereoselective synthesis for β2-agonists preparation are also presented.

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Uterine and Cardiovascular Effects of Ritodrine in Premature Labor

Cited by 37 publications

References 0 publications

Effects of maternal ritodrine hydrochloride administration on the heart rate of preterm fetal sheep with intraamniotic inflammation

Effects of maternal ritodrine hydrochloride administration on the heart rate of preterm fetal sheep with intraamniotic inflammation

Verapamil to inhibit the cardiovascular side effects of ritodrine

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

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