Uterine arterial embolization: collagen analysis of endometrial/uterine biopsy pre and after procedure

Abstract

The objective of this study was to evaluate collagen of endometrial/uterine tissue before and after uterine arterial embolization (UAE). Fifteen consecutive patients with a diagnosis of uterine fibroids were included. Clinical diagnosis of uterine fibroids had been confirmed by ultrasonography. Uterine arterial embolization procedure was performed with microsphere with 300-700-my diameter. Selective catheterization of uterine arteries was carried through bilaterally and was guided by angiography. For collagen evaluation, endometrial biopsy was taken in secretory phase with Novak curette before UAE and 3 months after the procedure. Groups were assessed for analysis using Student's t test. Collagen fibers percentage was reduced (p<0.0001) in the group after UAE (81.05± 1.50) comparing the group before UAE (84.08±1.46). In conclusion, there is a significant reduction in collagen of endometrial/uterine tissue in patients submitted to UAE.