Uterine artery Doppler at 11 + 0 to 13 + 6 weeks in the prediction of pre‐eclampsia

Plasencia, W.; Maíz, Nerea; Bonino, S; Kaihura, C.; Nicolaides, Kypros H.

doi:10.1002/uog.5157

Cited by 386 publications

(429 citation statements)

References 26 publications

Supporting

Mentioning

380

Contrasting

Unclassified

Order By: Relevance

“…38 Similarly, the association between early-PE with high uterine artery PI and low serum PAPP-A is compatible with findings of extensive studies implicating impaired placental development and function in the pathogenesis of early-PE. [7][8][9] In the unaffected controls, the maternal serum concentration of IGFBP-3 decreased with fetal crown-rump length and was lower in women using ovulation induction drugs. Consequently, the measured concentration of IGFBP-3 in maternal serum was adjusted for these factors before comparing with pathological pregnancies.…”

Section: Discussionmentioning

confidence: 95%

“…34,35 We recorded maternal characteristics and medical history, stored serum at À80 1C for subsequent biochemical analysis and performed transabdominal pulsed Doppler for measurement of the left and right uterine artery PI and recorded the mean value. 7 Written informed consent was obtained from the women agreeing to participate in the study, which was approved by King's College Hospital Ethics Committee.…”

Section: Study Populationmentioning

confidence: 99%

“…1,2 The underlying mechanism for early-PE, requiring delivery before 34 weeks, is thought to be impaired placentation because of inadequate trophoblastic invasion of the maternal spiral arteries, which has been documented by the findings of both histologic and Doppler ultrasound studies of the uterine arteries, [3][4][5][6][7][8] reduced maternal serum concentration of the placental product pregnancy-associated plasma protein-A (PAPP-A) 9 and impaired fetal growth. 10 In contrast late-PE, which is usually associated with normal placentation and fetal growth, 11,12 is thought to be a manifestation of an underlying metabolic disorder with increased insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

“…[31][32][33] The aims of our study were first, to investigate the maternal serum concentrations of IGFBP-3 at 11-13 weeks in pregnancies that subsequently develop PE and second, to examine the possible association with uterine artery pulsatility index (PI) and maternal serum PAPP-A, which reflect early placental perfusion and function and are altered in pregnancies that subsequently develop PE. 7,9 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maternal serum insulin-like growth factor-binding protein-3 (IGFBP-3) at 11–13 weeks in preeclampsia

et al. 2011

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal serum insulin-like growth factor-binding protein-3 (IGFBP-3) at 11–13 weeks in preeclampsia

et al. 2011

View full text Add to dashboard Cite

“…It has also been demonstrated that uterine artery Doppler indices at the end of the first trimester may also predict preeclampsia, FGR, placental abruption and stillbirth, although with less sensitivity and specificity than second trimester measures [33][34][35][36][37][38][39]. More recently, longitudinal studies have reported progressive deterioration of uterine artery Doppler indices in women who go on to develop preeclampsia [34].…”

Section: Uterine Artery Dopplermentioning

confidence: 99%

Role of uteroplacental and fetal Doppler in identifying fetal growth restriction at term

Khalil

Thilaganathan

2017

Best Practice & Research Clinical Obstetrics & Gynaecol

View full text Add to dashboard Cite

Identification of the fetus at risk of adverse outcome at term is a challenge to both clinicians and researchers alike. Despite the fact that fetal growth restriction (FGR) is a known risk factor for stillbirth, at least two thirds of the stillbirth cases at term are not small for gestational age (SGA) -a commonly used proxy for FGR. However, the majority of SGA fetuses are constitutionally small babies and do not suffer from adverse perinatal outcome. Doppler cerebroplacental ratio (CPR) is emerging as a marker of failure to reach growth potential at term. CPR is an independent predictor of intrapartum fetal distress, admission to the neonatal unit at term, stillbirth, perinatal death and neonatal morbidity. Raised uterine artery Doppler resistance in the third trimester is independently associated with significantly lower birthweight and CPR. The combination of the estimated fetal weight, CPR and uterine Doppler in the third trimester can identify the majority of fetuses at risk of stillbirth. HIGHLIGHTS Despite the fact that fetal growth restriction (FGR) is a known risk factor for stillbirth, the majority of fetuses suffering from stillbirth at term are not small for gestational age. Serial measurements to assess growth velocity, combined with fetal Doppler, are preferable than a single point estimate. The cerebroplacental ratio (CPR) is emerging as a marker of failure to reach growth potential at term  The combination of the estimated fetal weight, CPR and uterine Doppler in the third trimester can identify the majority of fetuses at risk of stillbirth Highlights (for review) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 ABSTRACT Identification of the fetus at risk of adverse outcome at term is a challenge to both clinicians and researchers alike. Despite the fact that fetal growth restriction (FGR) is a known risk factor for stillbirth, at least two thirds of the stillbirth cases at term are not small for gestational age (SGA) -a commonly used proxy for FGR. However, the majority of SGA fetuses are constitutionally small babies and do not suffer from adverse perinatal outcome. Doppler cerebroplacental ratio (CPR) is emerging as a marker of failure to reach growth potential at term. CPR is an independent predictor of intrapartum fetal distress, admission to the neonatal unit at term, stillbirth, perinatal death and neonatal morbidity. Raised uterine artery Doppler resistance in the third trimester is independently associated with significantly lower birthweight and CPR. The combination of the estimated fetal weight, CPR and uterine Doppler in the t...

show abstract

Preeclampsia Screening

Henderson

Thompson

Burda

et al. 2017

JAMA

105

View full text Add to dashboard Cite

IMPORTANCE Preeclampsia is a complex disease of pregnancy with sometimes serious effects on maternal and infant morbidity and mortality. It is defined by hypertension after 20 weeks' gestation and proteinuria or other evidence of multisystem involvement.OBJECTIVE To systematically review the benefits and harms of preeclampsia screening and risk assessment for the US Preventive Services Task Force.

show abstract

Uterine artery Doppler at 11 + 0 to 13 + 6 weeks in the prediction of pre‐eclampsia

Abstract: Objective To determine the performance of screening for pre-eclampsia (PET) by maternal characteristics and uterine artery pulsatility index (PI) at 11 + 0 to 13 + 6 weeks' gestation. Methods

Cited by 386 publications

References 26 publications

Maternal serum insulin-like growth factor-binding protein-3 (IGFBP-3) at 11–13 weeks in preeclampsia

Maternal serum insulin-like growth factor-binding protein-3 (IGFBP-3) at 11–13 weeks in preeclampsia

Role of uteroplacental and fetal Doppler in identifying fetal growth restriction at term

Preeclampsia Screening

Contact Info

Product

Resources

About