Uterine artery Doppler in singleton pregnancies conceived after <i>in‐vitro</i> fertilization or intracytoplasmic sperm injection with fresh <i>vs</i> frozen blastocyst transfer: longitudinal cohort study

Cavoretto, Paolo; Farina, Antonio; Gaeta, G.; Sigismondi, Cristina; Spinillo, S.; Casiero, D.; Pozzoni, Mirko; Viganò, Paola; Papaleo, Enrico; Candiani, Massimo

doi:10.1002/uog.21969

Cited by 48 publications

(42 citation statements)

References 65 publications

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“…In addition, only fresh embryos, frozen embryos and days of transplantation were recorded for transplantation, but not blastocyst transplantation, so we were unable to further analyze the results of blastocyst transplantation. Previous studies have found lower uterine artery pulsatility index, proportion of small-for-gestational-age (SGA) [31] decreased risks of preterm \birth and low birth weight babies but a higher risk of large for GA babies as well as hypertensive disorders of pregnancies associated with pregnancies conceived from frozen embryos compared to fresh transfer [32]. While the difference between fresh and frozen embryos needs to be further confirmed by our follow-up studies.…”

Section: Discussionmentioning

confidence: 49%

Reference intervals of gestational sac, yolk sac, embryonic length, embryonic heart rate at 6–10 weeks after in vitro fertilization-embryo transfer

Ouyang

Qin

Lin

et al. 2020

BMC Pregnancy Childbirth

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Background Accurately determining the normal range of early pregnancy markers can help to predict adverse pregnancy outcomes. The variance in ovulation days leads to uncertain accuracy of reference intervals for natural pregnancies. While the gestational age (GA) is accurate estimation during in vitro fertilization-embryo transfer (IVF-ET). Thus, the objective of this research is to construct reference intervals for gestational sac diameter (GSD), yolk sac diameter (YSD), embryonic length (or crown–rump length, CRL) and embryonic heart rate (HR) at 6–10 gestational weeks (GW) after IVF-ET. Methods From January 2010 to December 2016, 30,416 eligible singleton pregnancies were retrospectively recruited. All included participants had full records of early ultrasound measurements and phenotypically normal live neonates after 37 GW, with birth weights > the 5th percentile for gestational age. The curve-fitting method was used to screen the optimal models to predict GSD, CRL, YSD and HR based on gestational days (GD) and GW. Additionally, the percentile method was used to calculate the 5th, 50th, and 95th percentiles. Results There were significant associations among GSD, CRL, YSD, HR and GD and GW, the models were GSD = − 29.180 + 1.070 GD (coefficient of determination [R2] = 0.796), CRL = − 11.960 - 0.147 GD + 0.011 GD2 (R2 = 0.976), YSD = − 2.304 + 0.184 GD - 0.011 GD2 (R2 = 0.500), HR = − 350.410 + 15.398 GD - 0.112 GD2 (R2 = 0.911); and GSD = − 29.180 + 7.492 GW (R2 = 0.796), CRL = − 11.960 - 1.028 GW + 0.535 GW2 (R2 = 0.976), YSD = − 2.304 + 1.288 GW - 0.054 GW2 (R2 = 0.500), HR = − 350.410 + 107.788 GW - 5.488 GW2 (R2 = 0.911), (p < 0.001). Conclusions Reference intervals for GSD, YSD, HR and CRL at 6–10 gestational weeks after IVF-ET were established.

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Section: Discussionmentioning

confidence: 49%

Reference intervals of gestational sac, yolk sac, embryonic length, embryonic heart rate at 6–10 weeks after in vitro fertilization-embryo transfer

Ouyang

Qin

Lin

et al. 2020

BMC Pregnancy Childbirth

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“…Ultrasound examinations have a major role as an intraoperative aid for IVF procedures [10,11] and also in the prenatal risk assessment of the resulting pregnancies. This is principally due to uterine artery Doppler studies [7,12,13].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study

et al. 2020

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Oocyte donations (OD) represent 4.5% of all in vitro fertilization (IVF) cycles. While OD pregnancies face increased risks of obstetrical complications, especially pregnancy-induced hypertension and pre-eclampsia (PE), little is known about the physiology and the physiopathology of placentation. We performed a prospective case-control study to analyze uterine artery Doppler pulsatility index (UtA-PI) and serum maternal 17β-estradiol (17β-E) at 11 + 0 to 13 + 6 weeks’ gestation in singleton pregnancies with different modes of conception. Study groups were: 55 OD, 48 IVF with autologous oocytes from fresh cycles (Autologous-Fresh IVF), 10 IVF with autologous oocytes from frozen cycles (Autologous-Frozen IVF) and 122 spontaneously conceived pregnancies (SC). The mean UtA-PI and serum maternal 17β-E at 11 to 13 + 6 weeks were significantly lower in OD as compared to SC and autologous IVF, either from fresh or frozen cycles. Oocyte donation presents lower UtA-PI and lower serum 17β-E in the first trimester of pregnancy. The etiology of these particularr differences is likely multifactorial and deserves further investigation.

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“…The multivariable model was adjusted for maternal age, gravidity, parity, prepregnancy obesity (body mass index≥28 kg/m 2 ) [27], birth plurality, and history of previous caesarean section; the results are reported as adjusted odds ratios (aORs) and 95% con dence intervals (CIs). Centiles birthweight were calculated from reference equation of published dataset on similar population and study groups [28,29]. P values of less than 0.05 were considered statistically signi cant.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, women with endometriosis exhibit defective deep placentation because of defective remodeling of the spiral arteries [39]. P Cavoretto found that in a longitudinal cohort study of uterine artery Doppler in singleton pregnancies, different uterine arteries perfusion(with lower pulsatility index) occurring in frozen as compared to fresh embryo transfer pregnancy from the rst to the third trimester, related to higher birth weight in frozen as compared to fresh IVF/ICSI [28]. Which may indicate that pregnancy outcomes are affected by uterine arteries prefusion.…”

Section: Summary Of Key Ndingsmentioning

confidence: 99%

Pregnancy outcomes of Chinese women undergoing IVF with embryonic cryopreservation as compared to natural conception

wang

Liu

Deng

et al. 2020

Preprint

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Background: To examine differences in the maternal characteristics and pregnancy outcomes of Chinese women with various causes of infertility who underwent in vitro fertilization (IVF) with embryonic cryopreservation treatment.Methods: Cases were pregnancies after IVF-ET with embryonic cryopreservation; controls were spontaneously conceived pregnancies. Subgroup analysis was carried out according to etiology of infertility. The IVF treatment group was divided into 5 subgroups according to infertility etiology as follows: ovulation disorder, tubal disease, male infertility, endometriosis, and mixed infertility. Data on demographic characteristics, medical history, laboratory tests, and delivery were reviewed. Logistic regression analysis was performed for pregnancy and perinatal complications and neonatal outcomes. The multivariable model was adjusted for potential confounders.Results: Among singleton pregnancies, compared with spontaneous pregnancies, IVF pregnancies were associated with significant increases in the rates of the following: gestational diabetes mellitus (GDM) (aOR 1.76[95% CI 1.33-2.33]), preeclampsia (2.60[1.61-4.20]), preterm preeclampsia (4.52[2.03-10.06]), postpartum hemorrhage (1.57[1.04-2.36]), intrahepatic cholestasis of pregnancy (3.84[1.06-13.94]), preterm premature rupture of membranes (2.11[1.17-3.81]), preterm birth (1.95[CI 1.26-3.01]), low birthweight (1.90[1.13-3.20]), macrosomia (1.53[1.03-2.27]), and neonatal intensive care unit (NICU) admission (1.69[1.22-2.34]) in the ovulation disorder group; GDM (1.50[1.21-1.86]), placenta previa (2.70[1.59-4.59]), placenta accreta (1.78[1.10-2.89]), postpartum hemorrhage (1.61[1.19-2.18]), macrosomia (1.60[1.21-2.13]) and 5-minute Apgar score ≤7 (4.09[1.04-16.08]) in the tubal disease group; placenta previa (9.33[4.22-20.62]), small for gestational age (2.29[1.04-5.08]), macrosomia (2.00[1.02-3.95]) and NICU admission (2.35[1.35-4.09]) in the endometriosis group; placenta previa (4.14[2.23-7.68]) and placenta accreta (2.05[1.08-3.87]) in the male infertility group; and GDM (1.85[1.15-2.98]), placenta previa (4.73[1.83-12.21]), placental abruption (3.39[1.20-9.56]), chorioamnionitis (2.93[1.04-8.26]), preterm birth (2.69[1.41-5.15]), and 1-minute Apgar score ≤7 (4.68[1.62-13.51]) in the mixed infertility group. Among multiple pregnancies, most of the differences that were significant in singleton pregnancies were less extensive or had disappeared.Conclusions: Infertility etiology within the IVF population was found to affect maternal and neonatal outcomes among all births. During the perinatal period, infertility etiology appears to be an additional risk factor for abnormal pregnancy outcomes besides the use of IVF techniques compared with spontaneous pregnancies. Higher risk was found for ovulation disorders, and lower risk was found for male infertility.

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Uterine artery Doppler in singleton pregnancies conceived after in‐vitro fertilization or intracytoplasmic sperm injection with fresh vs frozen blastocyst transfer: longitudinal cohort study

Cited by 48 publications

References 65 publications

Reference intervals of gestational sac, yolk sac, embryonic length, embryonic heart rate at 6–10 weeks after in vitro fertilization-embryo transfer

Reference intervals of gestational sac, yolk sac, embryonic length, embryonic heart rate at 6–10 weeks after in vitro fertilization-embryo transfer

Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study

Pregnancy outcomes of Chinese women undergoing IVF with embryonic cryopreservation as compared to natural conception

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